药理学发展趋势 (2023年第44卷第4期)
April 2023 Volume 44 Issue4(2023年4月第44卷第4期)
https://www.cell.com/trends/pharmacological-sciences/issue?pii=S0165-6147(22)X0005-9
Science & Society(科学与社会)
1. 对非甾体抗炎药在早期急性疼痛中应用的再思考
(Rethinking the use of NSAIDs in early acute pain)
作者:Marco Sisignano (Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Germany)
Spotllight(聚焦)
1. 降解物诱导的蛋白质-蛋白质界面的深入研究
(A deep dive into degrader-induced protein-protein interfaces)
作者:Pius Galli, Nicolas H. Thomä* (University of Basel, Switzerland; Friedrich Miescher Institute for Biomedical Research, Switzerland)
Forum(论坛)
1. 地高辛作为一种新兴的非心脏病治疗方法
(Digoxin as an emerging therapy in noncardiac diseases)
作者:Farzaneh Dashti, Fatima Jamshed, Xinshou Ouyang, Wajahat Z. Mehal, Bubu A. Banini* (Section of Digestive Diseases, Yale School of Medicine, USA)
2. 利用干细胞衍生的肾脏模型推进肾小球疾病的药物发现
(Advancing drug discovery for glomerulopathies using stem-cell-derived kidney models)
作者:Amanda D. Barreto, Morgan A. Burt, Samira Musah* (Department of Biomedical Engineering, Duke University, USA)
Opinion(意见)
1. 神经退行性变的3D模型:在药物发现中的应用
(3D models of neurodegeneration: implementation in drug discovery )
作者:Chloe Whitehouse (MSD R&D Innovation Centre, UK)
Reviews(综述)
1. 转移性结直肠癌癌症:机制和新兴治疗方法
(Metastatic colorectal cancer: mechanisms and emerging therapeutics)
作者:Alice E. Shin, Anil K. Rustgi* (Herbert Irving Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, USA)
2. MRGPRs的结构、功能和药理学
(The structure, function, and pharmacology of MRGPRs)
作者:Can Cao, Bryan L. Roth* (Department of Pharmacology, University of North Carolina School of Medicine, USA)
Drug of the Month(本月最佳药物)
1. 氘可来昔替尼(Sotyktu™)用于斑块型银屑病
(Deucravacitinib (Sotyktu™) for plaque psoriasis)
作者:Agnete Marie Granau, Ole Haagen Nielsen* (Department of Gastroenterology, Herlev Hospital, University of Copenhagen, Denmark)
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