一、临床药理学与治疗学 (2024年第116卷第4期)

October 2024 - Volume 116 - Issue 4 (2024年10月第116卷第4期)
https://ascpt.onlinelibrary.wiley.com/toc/15326535/2024/116/4

Editorial（社论）
1. 药物基因组学检测是否是全球患者治疗管理的重要工具？
Is Pharmacogenetic Testing a Vital Tool for Enhancing Therapeutic Management of Patients Worldwide?
Kathleen M. Giacomini* (University of California, USA)
Perspective（观点）
2. 推荐标准护理而非基因型基础处方的临床药物基因组学指南的价值
The Value of Clinical Pharmacogenomic Guidelines That Recommend Standard of Care Over Genotype-Based Prescribing
Roseann S. Donnelly* (Massachusetts College of Pharmacy and Health Sciences, USA)
Commentary（评论）
3. 药物基因组学处方指南：它们总是有用吗？
Pharmacogenomic Prescribing Guidelines: Are They Always Useful?
Magnus Ingelman-Sundberg* (Karolinska Institutet, Sweden)
White Paper（白皮书）
4. 临床药理学在多样性和全球药物开发中的包容性角色：当前实践和行业视角：白皮书
Role of Clinical Pharmacology in Diversity and Inclusion in Global Drug Development: Current Practices and Industry Perspectives: White Paper
Aarti Sawant-Basak* (Clinical Pharmacology and Pharmacometrics, AstraZeneca, USA)
Tutorial（教程）
5. 在学术医疗中心开发多方面药物基因组学采纳计划：实际考虑和经验教训
Development of a Multifaceted Program for Pharmacogenetics Adoption at an Academic Medical Center: Practical Considerations and Lessons Learned
Tyler Shugg, Todd C. Skaar* (ndiana University School of Medicine, USA)
CPIC Guidelines（CPIC指南）
6. 临床药物基因组学实施联盟(CPIC)指南：CYP2B6基因型和美沙酮治疗
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2B6 Genotype and Methadone Therapy
Katherine M. Robinson, Evan D. Kharasch* (University of Pittsburgh School of Pharmacy, USA; Duke University School of Medicine | Bermaride LLC, USA)
7. 临床药物基因组学实施联盟(CPIC)指南：CYP2D6、ADRB1、ADRB2、ADRA2C、GRK4和GRK5基因型及β受体阻滞剂治疗
Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2D6, ADRB1, ADRB2, ADRA2C, GRK4, and GRK5 Genotypes and Beta-Blocker Therapy
Julio D. Duarte* (University of Florida College of Pharmacy, USA)
Review（综述）
8. PharmVar基因焦点：CYP2A6
PharmVar GeneFocus: CYP2A6
Alec W.R. Langlois, Andrea Gaedigk* (University of Toronto, Canada; Children's Mercy Research Institute (CMRI), USA）
9. PharmVar基因焦点：CYP4F2
PharmVar GeneFocus: CYP4F2
Pablo Zubiaur, Andrea Gaedigk* (Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM) and Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa (IP), Spain; Toxicology & Therapeutic Innovation, Children's
Mercy Research Institute (CMRI), USA)
Mini Review（微综述）
10. 胰高血糖素的临床药理学
Clinical Pharmacology of Glucagon
Mohamad M. Kronfol* (US Food and Drug Administration, USA)
Research（研究）
Article（文章）
11. 在乌干达人群中绘制药物基因组学图景：对未充分代表人群的个性化医疗的影响
Mapping the Pharmacogenetic Landscape in a Ugandan Population: Implications for Personalized Medicine in an Underrepresented Population
Sumudu Rangika Samarasinghe, Shivashankar H. Nagaraj* (Queensland University of Technology, Australia)
12. 将临床变异性整合到PBPK模型中，用于评估托法替尼缓释剂型的虚拟生物等效性（单次和多次给药）
Integrating Clinical Variability into PBPK Models for Virtual Bioequivalence of Single and Multiple Doses of Tofacitinib Modified-Release Dosage Form
Vivek Purohit (Pfizer Worldwide Research and Development, USA)
13. CYP2D6抑制剂与CYP2D6阿片类药物的联用：与急诊科就诊疼痛的关联
Use of CYP2D6 Inhibitors with CYP2D6 Opioids: Association with Emergency Department Visits for Pain
Noor Ahmed Nahid, Julie A. Johnson* (University of Florida College of Pharmacy, USA)
14. 使用基于生理的药代动力学模型全面评估甲氨蝶呤的OATP和BCRP介导的药物-药物相互作用
Comprehensive Evaluation of OATP- and BCRP-Mediated Drug–Drug Interactions of Methotrexate Using Physiologically-Based Pharmacokinetic Modeling
Sejung Hwang, Jae-Yong Chung* (Seoul National University College of Medicine, Korea)
15. 直接比较日本患者中直接口服抗凝剂与华法林的有效性和安全性：日本全国队列研究
Direct Comparison of the Effectiveness and Safety Among Direct Oral Anticoagulants and Warfarin in Japanese Patients: Nationwide Cohort Study in Japan
Saki Katayama, Masahiro Tohkin* (Nagoya City University, Japan)
16. 确定一个安全且可耐受的卡马西平剂量范式，以促进有效评估CYP3A4诱导
Identification of a Safe and Tolerable Carbamazepine Dosing Paradigm that Facilitates Effective Evaluation of CYP3A4 Induction
Amita Datta-Mannan* (Eli Lilly and Company, USA)
17. 多中心药代动力学和药效学研究：帕博利珠单抗用于75岁及以上非小细胞肺癌患者
Multicenter Pharmacokinetic and Pharmacodynamic Study of Pembrolizumab for Non-small-Cell Lung Cancer in Patients Aged 75 Years and Older
Shigehiro Yagishita, Akinobu Hamada* (National Cancer Center Research Institute, Japan)
18. Vadadustat在健康志愿者和慢性肾脏病患者中的药代动力学、药效学和安全性
Pharmacokinetics, Pharmacodynamics, and Safety of Vadadustat in Healthy Volunteers and Patients with Chronic Kidney Disease
Pamela Navarro-Gonzales, Kevin Dykstra* (Akebia Therapeutics, Inc., USA)
19. 妊娠期和产后子宫颈阴道液中依法韦仑暴露的药物基因组学
Pharmacogenetics of Efavirenz Exposure in Cervicovaginal Fluid during Pregnancy and Postpartum
Oluwasegun Eniayewu, Adeniyi Olagunju* (University of Ilorin, Nigeria; University of Liverpool, UK)
20. 模型指导证据支持每2周一次与标准每周一次剂量计划的西妥昔单抗在转移性结直肠癌中的临床非劣效性
Model-informed Evidence for Clinical Non-inferiority of Every-2-Weeks Versus Standard Weekly Dosing Schedule of Cetuximab in Metastatic Colorectal Cancer
Ana-Marija Milenković-Grišić* (the healthcare business of Merck KGaA, Germany)
21. 评估预测药物基因组变异影响的in silico工具和分子动力学模拟的性能
Assessing the Performance of In silico Tools and Molecular Dynamics Simulations for Predicting Pharmacogenetic Variant Impact
Maryam Jamal AlSaeed, Larisa H. Cavallari* (University of Florida, USA)
22. 年龄依赖性的CYP450酶在甲硝唑代谢中的丰度：应用于儿童PBPK建模
Age-Dependent Abundance of CYP450 Enzymes Involved in Metronidazole Metabolism: Application to Pediatric PBPK Modeling
Md Masud Parvez, Bhagwat Prasad* (Washington State University, USA)
23. 整合HIV-1患者中多替拉韦的群体暴露-反应支持由相关内在和外在患者特征影响的临床反应桥接
Integrated Population Exposure–Response of Dolutegravir in HIV-1 Supports Bridging of Clinical Response Influenced by Relevant Intrinsic and Extrinsic Patient Characteristics
Hardik Chandasana* (GSK, USA)
24. 使用预处理和治疗中的预后生物标志物预测接受Atezolizumab治疗的晚期NSCLC患者的生存
Predicting Survival in Patients with Advanced NSCLC Treated with Atezolizumab Using Pre- and on-Treatment Prognostic Biomarkers
Sébastien Benzekry* (Centre Inria de l'Université Côte d'Azur, Cancer Research Center of Marseille, France)
25. CYP2C19基因型健康志愿者中由于药物-药物相互作用的表型转换
Phenoconversion Due to Drug–Drug Interactions in CYP2C19 Genotyped Healthy Volunteers
Kenza Abouir, Caroline Flora Samer* (Geneva University Hospitals, Switzerland)
26. PBPK建模恩曲替尼及其活性代谢物以推导与CYP3A4抑制剂联合使用的儿科人群中的剂量调整
PBPK Modeling of Entrectinib and Its Active Metabolite to Derive Dose Adjustments in Pediatric Populations Co-Administered with CYP3A4 Inhibitors
Kenichi Umehara* (Roche Innovation Center, F. Hoffmann-La Roche Ltd., Switzerland)

二、药理学评论

 (本刊为双月刊，每两月更新一次，详见2024年11月更新)

三、先进药物输送评论 (2024年第213卷)

October 2024 - Volume 213  (2024年10月第213卷)
https://www.sciencedirect.com/journal/advanced-drug-delivery-reviews/vol/213/suppl/C

Review article（综述文章）
1. 传染病RNA疫苗设计与递送的最新进展
Advances in the design and delivery of RNA vaccines for infectious diseases
Abhijeet Girish Lokras, Camilla Foged* (University of Copenhagen, Denmark)
2. 移植中局部免疫调节的药物递送策略：弥合转化研究的鸿沟
Drug delivery strategies for local immunomodulation in transplantation: Bridging the translational gap
Afsana Naaz* (University of Pittsburgh, USA)
3. 纳米颗粒可变形性对多尺度生物传输的影响
Effects of nanoparticle deformability on multiscale biotransport
Hytham H. Gadalla, Yoon Yeo* (Purdue University, USA)

四、药理学发展趋势 (2024年第45卷第10期)

October 2024 - Volume 45 - Issue 10 (2024年10月第45卷第10期)
https://www.cell.com/trends/pharmacological-sciences/issue?pii=S0165-6147(23)X0011-X

Spotlight（聚焦）
1. 保护你的肠道调节性T细胞免受痛苦！
Spare the pain for your gut Treg cells!
Manon Defaye, Christophe Altier* (University of Calgary, Canada)
Forums（论坛）
2. 针对脑缺血-再灌注损伤的TRPM通道
Targeting TRPM channels for cerebral ischemia–reperfusion injury
Dai-Qiang Liu,Wei Mei* (Tongji Hospital, Huazhong University of Science and Technology, China)
3. 针对白色脂肪组织以对抗胰岛素抵抗
Targeting white adipose tissue to combat insulin resistance
Yiheng Huang, Dake Qi* (University of Manitoba, Canada)
Opinions（观点）
4. 神经丝蛋白轻链链作为化疗诱导的周围神经病变的生物标志物
Neurofilament light chain as a biomarker of chemotherapy-induced peripheral neuropathy
Nanna E. Andersen, Tore B. Stage (University of Southern Denmark, Denmark)
5. 量子计算如何应用于临床试验设计和优化？
How can quantum computing be applied in clinical trial design and optimization?
Hakan Doga* (IBM Quantum, Almaden Research Center, USA)
Reviews（综述）
6. 溃疡性结肠炎：临床生物标志物、治疗靶点和新兴治疗方法
Ulcerative colitis: clinical biomarkers, therapeutic targets, and emerging treatments
Phurpa Wangchuk* (James Cook University, Australia)
7. 固体肿瘤中SYK靶点的新见解
New insights into SYK targeting in solid tumors
Shweta Joshi* (University of California, USA)
8. 正常和白血病干细胞的代谢调控
Metabolic regulation in normal and leukemic stem cells
Cheuk-Him Man* (Sun Yat-sen University, China)
9.工程化细胞外囊泡用于诊断和治疗
Engineering extracellular vesicles for diagnosis and therapy
Zhengyue Fei, Guannan Liu* (Nanjing Tech University, China)
Drug of the Month（本月药物）
10.Ensifentrine (Ohtuvayre™) 用于慢性阻塞性肺疾病
Ensifentrine (Ohtuvayre™) for chronic obstructive pulmonary disease
Sandra Hubert, Frédéric De Ceuninck* (R&D Servier Institute Paris-Saclay, France)

五、药理学与治疗学 (2024年第262卷)

October 2024 - Volume 262  (2024年10月第262卷)
https://www.sciencedirect.com/journal/pharmacology-and-therapeutics/vol/262/suppl/C

Review article（综述文章）
1. 组织特异性激活胰岛素信号作为肥胖相关代谢紊乱的潜在靶点
Tissue-specific activation of insulin signaling as a potential target for obesity-related metabolic disorders
Hideyuki Okuma, Kyoichiro Tsuchiya* (University of Yamanashi, Japan)
2. 进入TiME机器：年龄相关肿瘤免疫微环境变化如何影响黑色素瘤进展和治疗反应
Entering the TiME machine: How age-related changes in the tumor immune microenvironment impact melanoma progression and therapy response
Alexis E. Carey, Ashani T. Weeraratna* (Johns Hopkins Bloomberg School of Public Health, USA)
3. C型利钠肽 (CNP)：心血管系统及其以外的领域
C-type natriuretic peptide (CNP): The cardiovascular system and beyond
Yasmin A. Dickinson, Adrian J. Hobbs* (Queen Mary University of London, UK)
4. 针对器官特异性线粒体功能障碍以改善生物衰老
Targeting organ-specific mitochondrial dysfunction to improve biological aging
Corina T. Madreiter-Sokolowski* (Medical University of Graz, Austria)
5. 嘌呤能信号概述及其在癌症治疗中的作用
Overview of the role of purinergic signaling and insights into its role in cancer therapy
Francesco Di Virgilio* (University of Ferrara, Italy)
6. 肾脏疾病中的微小RNA (microRNA)：调控、治疗学和生物标志物潜力
microRNAs in kidney diseases: Regulation, therapeutics, and biomarker potential
Zhiwen Liu* (The Second Xiangya Hospital at Central South University, China)

六、药物 (2024年第84卷第10期)

October 2024 - Volume 84 - Issue 10 (2024年10月第84卷第10期)
https://link.springer.com/journal/40265/volumes-and-issues/84-10

Current Opinion（当前观点）
1. 从药代动力学角度个体化剂量的抗微生物药物：当前格局
Dose Individualisation of Antimicrobials from a Pharmacometric Standpoint: The Current Landscape
Tim Preijers,  Birgit C. P. Koch (University Medical Centre Rotterdam, The Netherlands)
Leading Article（重点文章）
2. 靶向鞘氨醇-1-磷酸途径：炎症性肠病管理中的新机遇
Targeting the Sphingosine-1-Phosphate Pathway: New Opportunities in Inflammatory Bowel Disease Management
Konstantina Kitsou, Giorgos Bamias* (National and Kapodistrian University of Athens, Greece; GI-Unit, Greece)
Review Article（综述文章）
3. 慢性肾脏病中的抗凝治疗
Anticoagulation in Chronic Kidney Disease
Marco Montomoli* (Hospital Clínico Universitario de Valencia, Spain)
4. 头孢吡肟-他尼巴坦：一种新型头孢菌素/β-内酰胺酶抑制剂组合
Cefepime–Taniborbactam: A Novel Cephalosporin/β-Lactamase Inhibitor Combination
George G. Zhanel* (University of Manitoba, Canada)
5. 哮喘和心血管疾病：导航相互药理学干扰
Asthma and Cardiovascular Diseases: Navigating Mutual Pharmacological Interferences
Mario Cazzola* (University of Rome ‘Tor Vergata’, Italy)
Systematic Review（系统综述）
6. CYP2C19 基因型状态对有症状冠状动脉疾病、中风和外周动脉疾病患者临床结果的影响：系统综述和Meta分析
Impact of CYP2C19 Genotype Status on Clinical Outcomes in Patients with Symptomatic Coronary Artery Disease, Stroke, and Peripheral Arterial Disease: A Systematic Review and Meta-Analysis
Dominique P. M. S. M. Maas* (Radboud University Medical Center, The Netherlands)
Original Research Article（原创研究文章）
7. 基于两项III期试验汇总分析的曲伏前列素眼内植入剂长期安全性和有效性评估
Long-Term Safety and Efficacy Evaluation of Travoprost Intracameral Implant Based on Pooled Analyses from Two Phase III Trials
I. Paul Singh, Tomas Navratil* (The Eye Centers of Racine and Kenosha, USA; Glaukos Corporation, USA)
AdisInsight Report（AdisInsight报告）
8. Donanemab：首次批准
Donanemab: First Approval
Connie Kang
9. Golidocitinib：首次批准
Golidocitinib: First Approval
Susan J. Keam
10. Vorasidenib：首次批准
Vorasidenib: First Approval
Yvette N. Lamb

七、药理学研究 (2024年第208卷)

October 2024 - Volume 208 (2024年10月第208卷)
https://www.sciencedirect.com/journal/pharmacological-research/vol/208/suppl/C

Review Articles（综述文章）
1. CX3C趋化因子：纤维化和衰老的标志
CX3C chemokine: Hallmarks of fibrosis and ageing
Xuanning Chen, Lingyong Jiang* (Shanghai Jiao Tong University, China; Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, China)
2. 嵌合抗原受体 (CAR) T细胞疗法：利用细胞外囊泡增强疗效
Chimeric antigen receptor (CAR) T-cell therapy: Harnessing extracellular vesicles for enhanced efficacy
Beatrice Spokeviciute, Maria Felice Brizzi* (University of Torino, Italy)
3. 远红外辐射及其治疗参数：未来再生医学的优越选择？
Far-infrared radiation and its therapeutic parameters: A superior alternative for future regenerative medicine?
Bo Qin, Vincent Kam Wai Wong* (Macau University of Science and Technology, Macao, China)
4. ATF家族成员作为癌症治疗靶点：从机制到药理学干预
ATF family members as therapeutic targets in cancer: From mechanisms to pharmacological interventions
Xueyao Zhang, Peng Miao* (The First Hospital of China Medical University, China)
5. 针对铁死亡作为潜在的预防和治疗衰老相关疾病的策略
Targeting ferroptosis as a potential prevention and treatment strategy for aging-related diseases
Taiwei Jiao, Lina Yang* (The First Hospital of China Medical University, China)
6. 全面评估玻璃体内faricimab对视网膜疾病的影响：系统综述、荟萃分析和试验序贯分析
Comprehensive assessment of the impact of intravitreal faricimab on retinal diseases: A systematic review, meta-analysis, and trial sequential analysis
Guanran Zhang, Junran Sun* (Shanghai General Hospital, Shanghai Jiao Tong University, China)
7. 二甲双胍：从糖尿病到癌症到延长寿命
Metformin: From diabetes to cancer to prolongation of life
Cesare R. Sirtori* (Center of Dyslipidemias, ASST Grande Ospedale Metropolitano Niguarda, Italy)
8. 血清和糖皮质激素调节激酶1 (SGK1)作为心脏病的新兴治疗靶点
Serum and glucocorticoid-regulated kinase 1 (SGK1) as an emerging therapeutic target for cardiac diseases
Fatemeh Yarmohammadi, Gholamreza Karimi* (Kermanshah University of Medical Sciences, Iran; Mashhad University of Medical Sciences, Iran)
9. 骨质疏松中的细胞生死事件：所有道路通向线粒体动态
Cell life-or-death events in osteoporosis: All roads lead to mitochondrial dynamics
Zhichao Li, Wenxiang Cheng* (Shandong University of Traditional Chinese Medicine, China; Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, China)
10. 营养保健品在自主神经功能及相关疾病管理中的应用：全面综述
Nutraceuticals in the management of autonomic function and related disorders: A comprehensive review
Paulo César Trindade Costa, José Luiz de Brito Alves* (Federal University of Paraíba, Brazil)
11. 中医药和植物源性天然产物在调节甘油三酯代谢中的作用：机制和治疗潜力
Traditional Chinese medicine and plant-derived natural products in regulating triglyceride metabolism: Mechanisms and therapeutic potential
Zhou Jin, Xiaolong Wang* (Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, China)
12. 手性无机纳米材料在肿瘤微环境中的作用：癌症治疗的新篇章
Chiral inorganic nanomaterials in the tumor microenvironment: A new chapter in cancer therapy
Xueyi Song* (China Medical University, China)
13. 非酒精性脂肪肝病 (NAFLD) 相关的肝细胞癌 (HCC) ——重新定位现有mTORc1抑制剂的有力案例
NAFLD-associated hepatocellular carcinoma (HCC) – A compelling case for repositioning of existing mTORc1 inhibitors
Nutan Sharma, Dinesh Mahajan* (Center for Drug Discovery, BRIC-Translational Health Science and Technology Institute, India)
14. 人工智能在天然多酚类抗癌治疗药物开发中的作用：当前进展和未来展望
The role of artificial intelligence in the development of anticancer therapeutics from natural polyphenols: Current advances and future prospects
Ying Zheng, Qing Zhu* (West China Hospital, Sichuan University, China)
15. 线粒体转移作为增强癌细胞适应性的策略：当前见解和未来方向
Mitochondrial Transfer as a Strategy for Enhancing Cancer Cell Fitness:Current Insights and Future Directions
Veronica Marabitti, Silvia Campello* (University of Rome Tor Vergata, Italy)
16. 探究自噬与糖尿病神经病变之间的相互作用：揭开疾病病理的隐藏秘密
Investigating the interplay between mitophagy and diabetic neuropathy: Uncovering the hidden secrets of the disease pathology
Kiavash Hushmandi* (Baqiyatallah University of Medical Sciences, Iran)
17. 改善胶质瘤药物递送：胶质瘤药物开发的多方面方法
Improving glioma drug delivery: A multifaceted approach for glioma drug development
Marybeth G. Yonk, Kecheng Lei* (Emory University School of Medicine, USA)
18. 益生菌对非酒精性脂肪肝患者肝脏酶、肥胖指数、血压、血脂和炎症的影响：随机对照试验的系统综述和荟萃分析
The effect of synbiotics on liver enzymes, obesity indices, blood pressure, lipid profile, and inflammation in patients with non-alcoholic fatty liver: A systematic review and meta-analysis of randomized controlled trials
Vali Musazadeh, Behnam Najafiyan* (Iran University of Medical Sciences, Iran; Shiraz University of Medical Sciences, Iran)
19. 胶体自组装对两亲性药物生物反应的双面效应
The Janus effect of colloidal self-assembly on the biological response of amphiphilic drugs
Laura Fioretto, Emiliano Manzo* (CNR-Institute of Biomolecular Chemistry, Italy; Bio-Organic Chemistry Unit, CNR-Institute of Biomolecular Chemistry, Italy)
20. 中医药中内源性和外源性有毒物质的生物可利用性和生物利用度及其在风险评估中的意义
Bioaccessibility and bioavailability of exogenous and endogenous toxic substances in traditional Chinese medicine and their significance in risk assessment
Tian-Tian Zuo* (National Institutes for Food and Drug Control, China)
21. 胰高血糖素样肽-1受体激动剂与胃肠道癌症风险：随机对照试验的系统综述和荟萃分析
Glucagon-like peptide-1 receptor agonists and risk of gastrointestinal cancers: A systematic review and meta-analysis of randomized controlled trials
Gisella Figlioli* (Humanitas University, Italy)
22. GPCR介导的天然产物和化合物：治疗神经系统疾病的潜在治疗靶点
GPCR-mediated natural products and compounds: Potential therapeutic targets for the treatment of neurological diseases
Xing Xia Wang, Betty Yuen Kwan Law* (Macau University of Science and Technology, Macao SAR China)
23. Nod样受体：胶质母细胞瘤预后拼图的相关元素
Nod-like receptors: The relevant elements of glioblastoma`s prognostic puzzle
Marta Grabiec* (Centre of Postgraduate Medical Education, Poland)
24. 组蛋白去乙酰化酶及其抑制剂在神经系统疾病中的作用
Role of histone deacetylases and their inhibitors in neurological diseases
Li-Ying Zhang, Ni Yang* (Shengjing Hospital of China Medical University, China)
25. 肝脏疾病的新视角：聚焦于线粒体相关的内质网膜
A new perspective on liver diseases: Focusing on the mitochondria-associated endoplasmic reticulum membranes
Mengyu Guo, Xiaojiaoyang Li* (Beijing University of Chinese Medicine, China)
Regular Articles (常规文章)
26. 精神障碍患者唾液样本中大麻素1型和多巴胺D2受体基因的DNA甲基化：大麻使用有影响吗？
DNA methylation at cannabinoid type 1 and dopamine D2 receptor genes in saliva samples of psychotic subjects: Is there an effect of Cannabis use?
Martina Di Bartolomeo* (University of Teramo, Italy)
27. 乳腺癌中非组蛋白蛋白的甲基化修饰：新兴的靶向治疗策略
Methylation modification of non-histone proteins in breast cancer: An emerging targeted therapeutic strategy
Mingyao Huang, Da Qian* (Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, China; Zhejiang Provincial People's Hospital (Affiliated People’s Hospital), Hangzhou Medical College, China)
28. 星形胶质细胞中糖酵解产生的L-乳酸对早期阿尔茨海默病模型中记忆缺陷和Aβ负担的挽救作用
Regulation of glycolysis-derived L-lactate production in astrocytes rescues the memory deficits and Aβ burden in early Alzheimer’s disease models
Xiu Yang, Can Gao* (Xuzhou Medical University, China)
29. LIM激酶2激活心脏成纤维细胞，并通过经典和非经典Wnt途径的相互作用加剧梗死后左心室重构
LIM kinase 2 activates cardiac fibroblasts and exacerbates postinfarction left ventricular remodeling via crosstalk between the canonical and non-canonical Wnt pathways
Chenyi Gong, Lian Wang* (the Affiliated Hospital of Nanjing University Medical School, China)
30. 解码肝胆胰肿瘤微生物组代谢组：精准诊断和靶向治疗的途径
Decoding the microbiota metabolome in hepatobiliary and pancreatic cancers: Pathways to precision diagnostics and targeted therapeutics
Yuemiao Xu, Aiqin Zhang* (Zhejiang Chinese Medical University, China; Zhejiang Cancer Hospital, China)
31. 基于钌(II)-环戊二烯基化合物的新型联合治疗对抗顺铂耐药的非小细胞肺癌
A novel combinatory treatment against a CDDP-resistant non-small cell lung cancer based on a Ruthenium(II)-cyclopentadienyl compound
Iris C. Salaroglio, Chiara Riganti* (University of Torino, Italy)
32. 来源于Saccharomyces boulardii的抗氧化蛋白，硫氧还蛋白，通过转激活表皮生长因子受体改善肠道炎症
A Saccharomyces boulardii-derived antioxidant protein, thioredoxin, ameliorates intestinal inflammation through transactivating epidermal growth factor receptor
Xiali Qin, Hailong Cao* (Tianjin Key Laboratory of Digestive Diseases, China)
33. AAV-aMTD-Parkin，一种治疗性基因递送载体，增强帕金森病和阿尔茨海默病的运动和认知功能
AAV-aMTD-Parkin, a therapeutic gene delivery cargo, enhances motor and cognitive functions in Parkinson's and Alzheimer’s diseases
Seokwon Lee, Daewoong Jo* (Cellivery R&D Institute, Cellivery Therapeutics, Inc., South Korea)
34. 在tRNALeu(UUR)基因中累积的带有点突变的线粒体DNA在小鼠中引起脑功能障碍
Accumulation of mitochondrial DNA with a point mutation in tRNALeu(UUR) gene induces brain dysfunction in mice
Kaori Ishikawa* (University of Tsukuba, Japan)
35. 肠道微生物群-脑胆汁酸轴在小鼠中协调衰老相关的神经炎症和行为障碍
Gut microbiota-brain bile acid axis orchestrates aging-related neuroinflammation and behavior impairment in mice
Junli Ma, Lili Sheng* (Shanghai University of Traditional Chinese Medicine, China)
36. 关于支架植入后中度至重度钙化冠状动脉病变的双重抗血小板治疗持续时间的新见解
Novel insights on dual antiplatelet therapy duration following stenting for angiography-detected moderate-to-severe calcified coronary lesions
Zhangyu Lin, Kefei Dou* (Fuwai Hospital, National Center for Cardiovascular Diseases, China)
37. BET降解剂通过EGR1招募 septins 促进E2F1-3转录在三阴性乳腺癌中的抗增殖活性低于其抑制剂
BET degrader exhibits lower antiproliferative activity than its inhibitor via EGR1 recruiting septins to promote E2F1-3 transcription in triple-negative breast cancer
Nan Liu* (Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, China)
38. 肠道微生物代谢物：塑造未来对胃肠道癌症的诊断和治疗
Gut microbial metabolites: Shaping future diagnosis and treatment against gastrointestinal cancer
Hongyan Gou, Jun Yu* (CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR, China)
39. Omega-3多不饱和脂肪酸通过促进能量代谢减缓器官衰老
Omega-3 PUFAs slow organ aging through promoting energy metabolism
Yabing Xiong, Lili Zhou* (Southern Medical University, China)
40. 巨噬细胞靶向的氧化石墨烯纳米系统协同抗生素杀伤和宿主免疫防御结核病治疗
Macrophage targeted graphene oxide nanosystem synergize antibiotic killing and host immune defense for Tuberculosis Therapy
Jiang Pi* (Guangdong Medical University, China)
41. 二苯丙腈刺激的ERβ核积累通过与FOXO3A相互作用促进mdx小鼠中MyoD诱导的肌肉再生
Diarylpropionitrile-stimulated ERβ nuclear accumulation promotes MyoD-induced muscle regeneration in mdx mice by interacting with FOXO3A
Haowei Tong, Qinwei Yu* (State Key Laboratory of Natural Medicines, China Pharmaceutical University, China)
42. 药理分子伴侣恢复与癫痫相关的GABAA受体变体的蛋白质稳态
Pharmacological chaperones restore proteostasis of epilepsy-associated GABAA receptor variants
Ya-Juan Wang, Ting-Wei Mu* (Case Western Reserve University School of Medicine, USA)
43. F-ATP合酶抑制因子1和线粒体-细胞器相互作用：新见解和意义
F-ATP synthase inhibitory factor 1 and mitochondria-organelle interactions: New insight and implications
Lishu Guo* (Shanghai Tenth People's Hospital, School of Medicine, Tongji University, China)
44. Huperzine A靶向载脂蛋白E：基于组学分析的糖尿病肾病潜在治疗药物
Huperzine A targets Apolipoprotein E: A potential therapeutic drug for diabetic nephropathy based on omics analysis
Xiangjun Chen, Lidan Hu* (The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, China)
45. 双受体CB2大麻素受体的同源二聚化通过双价配体增强细胞信号传导
Homodimerization of CB2 cannabinoid receptor triggered by a bivalent ligand enhances cellular signaling
Gemma Navarro, Rafael Franco* (Universitat de Barcelona, Spain; Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Spain)
46. 多组学分析肠道-脑轴揭示动脉粥样硬化性脑小血管病患者新的微生物和神经递质特征
Multi-omics analysis of gut-brain axis reveals novel microbial and neurotransmitter signatures in patients with arteriosclerotic cerebral small vessel disease
Jiayuan Huang, Aimin Wu* (Shenzhen Campus of Sun Yat-Sen University, China; the Third Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, China)
47. 新型下丘脑途径对spexin代谢效应的影响
Novel hypothalamic pathways for metabolic effects of spexin
Penghua Fang* (First College of Clinical Medicine, Nanjing University of Chinese Medicine, China)
48. 创伤性脑损伤的生物能量学及其对大脑可塑性和功能的长期影响
The bioenergetics of traumatic brain injury and its long-term impact for brain plasticity and function
Pavan Thapak, Fernando Gomez-Pinilla* (University of California, USA)
49. 开发GPBAR1激动剂和RORγt反向激动剂用于治疗炎症性肠病
Development of dual GPBAR1 agonist and RORγt inverse agonist for the treatment of inflammatory bowel diseases
Michele Biagioli* (University of Perugia, Italy)

八、抗病毒研究 (2024年第230卷)

October 2024 - Volume 230 (2024年10月第230卷)
https://www.sciencedirect.com/journal/antiviral-research/vol/230/suppl/C

Research article（研究文章）
1. 人类巨细胞病毒进入粘膜上皮细胞的抑制
Inhibition of human cytomegalovirus entry into mucosal epithelial cells
Li He, Michael A. McVoy* (Virginia Commonwealth University, USA)
2. 基于马赛克神经氨酸酶的疫苗诱导针对同源和异源流感病毒的抗原特异性T细胞反应
Mosaic neuraminidase-based vaccine induces antigen-specific T cell responses against homologous and heterologous influenza viruses
Zirong Han, Caijun Sun* (Sun Yat-sen University, China)
3. 尼马瑞韦和莫努匹拉韦对流行SARS-CoV-2奥密克戎亚变体保持体外和体内强效抗病毒活性
Nirmatrelvir and molnupiravir maintain potent in vitro and in vivo antiviral activity against circulating SARS-CoV-2 omicron subvariants
Romel Rosales, Kris M. White* (Icahn School of Medicine at Mount Sinai, USA)
4. 抗-HBc反映HBV特异性CD8+ T细胞免疫反应的激活，并对HBV控制具有直接影响
Anti-HBc mirrors the activation of HBV-specific CD8+ T cell immune response and exhibits a direct effect on HBV control
Guofu Ye, Yongyin Li* (Nanfang Hospital, Southern Medical University, China)
5. 口服溶解膜作为潜在的疫苗载体以预防流感病毒感染
Orally dissolving film as a potential vaccine delivery carrier to prevent influenza virus infection
Keon-Woong Yoon, Fu-Shi Quan* (Kyung Hee University, Republic of Korea)
6. 在仓鼠模型中对多种SARS-CoV-2变体的治疗效果的抗体特性
Characterization of therapeutic antibody efficacy against multiple SARS-CoV-2 variants in the hamster model
Yu Cong, Michael R. Holbrook* (National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), USA)
7. 氨基罗卡格酸盐（ADRs），一类合成罗卡格酸盐，通过抑制病毒蛋白合成强效抑制SARS-CoV-2复制
Amidino-rocaglates (ADRs), a class of synthetic rocaglates, are potent inhibitors of SARS-CoV-2 replication through inhibition of viral protein synthesis
Patrick T. Keiser, Robert A. Davey* (Boston University Medical School, USA)
Short communication（短通讯）
8. RNA聚合酶PA-PB1相互作用抑制剂与奥司他韦对人禽流感病毒在细胞培养和体内具有协同活性
Synergistic activity of an RNA polymerase PA-PB1 interaction inhibitor with oseltamivir against human and avian influenza viruses in cell culture and in ovo
Anna Bonomini, Arianna Loregian* (University of Padua, Italy)
Research article（研究文章）
9. 针对病毒RNA主要蛋白酶区域的抗SARS-CoV-2 gapmer反义寡核苷酸
Anti-SARS-CoV-2 gapmer antisense oligonucleotides targeting the main protease region of viral RNA
Masako Yamasaki, Koichi Watashi* (National Institute of Infectious Diseases, Japan)
10. 在抗逆转录病毒体外传递实验中选择的HIV突变的全面数据库
Comprehensive database of HIV mutations selected during antiretroviral in vitro passage experiments
Kaiming Tao, Robert W. Shafer* (Stanford University, USA)
Short communication（短通讯）
11. 一种新的非洲猪瘟病毒活DNA标记系统显示双苯并咪唑Hoechst 33342可以有效地阻断其复制
A novel live DNA tagging system for African swine fever virus shows that bisbenzimide Hoechst 33342 can effectively block its replication
Veronica Martin* (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas, Spain)
Research article（研究文章）
12. 从MMV大流行响应盒中发现一种小分子KSHV裂解复制抑制剂
Discovery of a small-molecule inhibitor of KSHV lytic replication from the MMV pandemic response box
Michael O. Okpara, Adrienne L. Edkins* (Rhodes University, South Africa)
13. 通过叶酸转运体SLC19A1导入细胞外2′-3′cGAMP，建立限制单纯疱疹病毒-1的抗病毒反应
Import of extracellular 2′-3′cGAMP by the folate transporter, SLC19A1, establishes an antiviral response that limits herpes simplex virus-1
Zsuzsa K. Szemere, Eain A. Murphy* (SUNY-Upstate Medical University, USA)
14. 一种mpox四价mRNA疫苗保护小鼠免受致命天花病毒挑战
An mpox quadrivalent mRNA vaccine protects mice from lethal vaccinia virus challenge
Entao Li, Sandra Chiu* (University of Science and Technology of China, China)

九、英国药理学杂志 (2024年第181卷第19-20期)

（一）October 2024 - Volume 181 - Issue 19 (2024年10月第181卷第19期)
https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2024/181/19

MINI REVIEW（微综述）
1. 天然产物药理学：英国药理学杂志的视角
Natural product pharmacology: the British Journal of Pharmacology perspective
Xin Wang* (University of Manchester, UK)
RESEARCH ARTICLE（研究文章）
2. LRP5/6/GSK-3β/β-catenin在艾塞那肽和胰岛素促进2型糖尿病成骨和骨调节中差异的作用
Role of LRP5/6/GSK-3β/β-catenin in the differences in exenatide- and insulin-promoted T2D osteogenesis and osteomodulation
Zijun Chen, Xiangdong Liu* (Air Force Medical University, China)
3. TREK-1钾通道是肺动脉高压中血管舒张的潜在药理学靶点
The TREK-1 potassium channel is a potential pharmacological target for vasorelaxation in pulmonary hypertension
Réka Csáki, Péter Enyedi* (Semmelweis University, Hungary)
4. 脊髓Cav2.3（R型）钙通道在术后疼痛小鼠模型中的促痛作用
Pronociceptive role of spinal Cav2.3 (R-type) calcium channels in a mouse model of postoperative pain
Marcella de Amorim Ferreira, Juliano Ferreira* (Federal University of Santa Catarina, Brazil)
5. 胰岛素降解酶抑制增加未折叠蛋白反应并有利于肝脏脂质积累
Insulin-degrading enzyme inhibition increases the unfolded protein response and favours lipid accumulation in the liver
Marine Andres, Steve Lancel* (Univ. Lille, Inserm, U1177 - EGID Drugs and Molecules for Living Systems, France)
6. 含裸头草碱蘑菇中色胺类化合物的药理学和行为效应
Pharmacological and behavioural effects of tryptamines present in psilocybin-containing mushrooms
Ryan J. Rakoczy, Matthew S. McMurray* (Miami University, USA)
7. 大麻素CB1受体的正向变构调节增强内源性大麻素信号传导并改变ERK1/2磷酸化动力学
Positive allosteric modulation of the cannabinoid CB1 receptor potentiates endocannabinoid signalling and changes ERK1/2 phosphorylation kinetics
Hayley M. Green, Michelle Glass* (University of Otago, New Zealand)
8. 水飞蓟素，一种常用的非酒精性脂肪肝病治疗药物，通过上调肠道成纤维细胞生长因子15/19的表达发挥作用
Silibinin, a commonly used therapeutic agent for non-alcohol fatty liver disease, functions through upregulating intestinal expression of fibroblast growth factor 15/19
Yujie Bai, Yue Dai* (China Pharmaceutical University, China)
9. 二氟化血栓素A2通过靶向TP和IP受体揭示血小板激活和抑制途径之间的串扰
Difluorinated thromboxane A2 reveals crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors
Megan F. Allen, Ingeborg Hers* (University of Bristol, UK)
10. 气道上皮过表达的组织蛋白酶K通过激活上皮-间质营养单元诱导哮喘中的气道重塑
Airway epithelial overexpressed cathepsin K induces airway remodelling through epithelial–mesenchymal trophic unit activation in asthma
Ling Qin, Chi Liu* (Xiangya Hospital, Central South University, China)
11. PON2激动剂vutiglabridin通过促进自噬激活和线粒体功能缓解非酒精性脂肪性肝炎
Paraoxonase-2 agonist vutiglabridin promotes autophagy activation and mitochondrial function to alleviate non-alcoholic steatohepatitis
Gu-Choul Shin, Kyun-Hwan Kim* (Sungkyunkwan University, Republic of Korea)
12. 实验性结肠炎对茶碱处置和毒性的昼夜节律依赖性影响
Circadian time-dependent effects of experimental colitis on theophylline disposition and toxicity
Yi Yang, Shuai Wang* (The First Affiliated Hospital of Jinan University, China; Guangzhou University of Chinese Medicine, China)
13. 因子XII和前激肽释放酶促进小鼠微血管炎症和银屑病
Factor XII and prekallikrein promote microvascular inflammation and psoriasis in mice
Yurong Zhang, Miao Wang* (Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, China)
14. 腺苷A2A受体激动剂CGS21680通过YAP信号通路促进角膜上皮创伤愈合
An agonist of the adenosine A2A receptor, CGS21680, promotes corneal epithelial wound healing via the YAP signalling pathway
Qiuqin Sun, Wei Guo* (Optometry and Vision Science and Eye Hospital, Wenzhou Medical University, China)

（二）October 2024 - Volume 181 - Issue 20  (2024年10月第181卷第20期)
https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2024/181/20

REVIEW ARTICLE（综述文章）
1. 他汀类药物的非靶标效应：分子机制、副作用以及激酶的新兴作用
Off-target effects of statins: molecular mechanisms, side effects and the emerging role of kinases
Francisco Alejandro Lagunas-Rangel, Helgi B. Schiöth* (Uppsala University, Sweden)
RESEARCH ARTICLE（研究文章）
2. 基于NanoBiT和NanoBiT/BRET的实验允许在结直肠癌细胞模型中分析Wnt-3a与内源性Frizzled 7的结合动力学
NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding kinetics of Wnt-3a to endogenous Frizzled 7 in a colorectal cancer model
Lukas Grätz, Gunnar Schulte* (Karolinska Institute, Sweden)
3. 一种新型无标记、预平衡实验用于测定治疗性抗体在活细胞上的结合和解离速率常数
A novel, label-free, pre-equilibrium assay to determine the association and dissociation rate constants of therapeutic antibodies on living cells
Eric M. Janezic* (Genentech, Inc, USA)
4. 非线性血脑屏障运输和给药策略影响吗啡及其代谢物在疼痛矩阵中的受体占有率
Non-linear blood–brain barrier transport and dosing strategies influence receptor occupancy ratios of morphine and its metabolites in pain matrix
Divakar Budda, Elizabeth C. M. de Lange* (Leiden University, The Netherlands)
5. 通过在静脉和大脑中同时、秒级解析的原位测量，高精度观察药物间室运输
A high-precision view of intercompartmental drug transport via simultaneous, seconds-resolved, in situ measurements in the vein and brain
Julian Gerson, Tod E. Kippin* (University of California, USA)
6. HSP90β在糖酵解控制的甲基化修饰帮助下塑造Th17细胞的命运
HSP90β shapes the fate of Th17 cells with the help of glycolysis-controlled methylation modification
Ling Yang, Zhi-Feng Wei* (China Pharmaceutical University, China)
7. 小胶质细胞Forkhead box O3a缺乏通过调节过氧化物酶体增殖物激活受体-γ的表达减轻LPS诱导的神经炎症和抑郁样行为
Microglial forkhead box O3a deficiency attenuates LPS-induced neuro-inflammation and depressive-like behaviour through regulating the expression of peroxisome proliferator-activated receptor-γ
Rikang Wang* (Peking University Shenzhen Hospital, China)
8. 饮食诱导的肥胖小鼠中肝脏靶向的外周大麻素1受体反向拮抗剂TM38837的疗效
Efficacy in diet-induced obese mice of the hepatotropic, peripheral cannabinoid 1 receptor inverse agonist TM38837
Martin E. Cooper* (Martin E. Cooper, 7TM Pharma A/S, Denmark)
9. 与APP和tau小鼠模型中的焦虑相关的PNN相关视蛋白中间神经元中δ-GABAA受体的减少
Decreased extrasynaptic δ-GABAA receptors in PNN-associated parvalbumin interneurons correlates with anxiety in APP and tau mouse models of Alzheimer's disease
Weicong Zhang, Afia B. Ali* (UCL School of Pharmacy, UK)
10. 甘草次酸通过激活cGAS-STING信号通路阻断SARS-CoV-2感染
Glycyrrhetinic acid blocks SARS-CoV-2 infection by activating the cGAS-STING signalling pathway
Hui Qi, Zhen-hua Jia* (Hebei Academy of Integrated Traditional Chinese and Western Medicine, China)
11. NaV1.6对野生型和NaV1.6功能获得（GOF）小鼠癫痫控制中电压门控钠通道抑制剂疗效的贡献
The contribution of NaV1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and NaV1.6 gain-of-function (GOF) mouse seizure control
James P. Johnson Jr* (Xenon Pharmaceuticals Inc, Canada)
12. 一种新型海洋衍生的线粒体自噬诱导剂改善紫杉醇诱导的周围神经病变中的线粒体功能障碍和热过敏
A novel marine-derived mitophagy inducer ameliorates mitochondrial dysfunction and thermal hypersensitivity in paclitaxel-induced peripheral neuropathy
Sangwoo Im, Jeanho Yun* (Dong-A University, Republic of Korea)
13. 组蛋白去乙酰化酶抑制减轻由淀粉样β（Aβ）寡聚体诱导的认知缺陷和星形胶质细胞功能障碍
Histone deacetylase inhibition mitigates cognitive deficits and astrocyte dysfunction induced by amyloid-β (Aβ) oligomers
Luan Pereira Diniz, Flávia Carvalho Alcantara Gomes* (Universidade Federal do Rio de Janeiro, Brazil)
14. 肌醇三焦磷酸预防大鼠单克罗塔林诱导的肺动脉高压中的右心室衰竭并提高生存率
Myo-inositol trispyrophosphate prevents right ventricular failure and improves survival in monocrotaline-induced pulmonary hypertension in the rat
Marta Oknińska, Michał Mączewski* (Centre of Translational Research, Centre of Postgraduate Medical Education, Poland)
15. IDH2-NADPH途径通过抑制腺泡细胞铁死亡保护急性胰腺炎
IDH2-NADPH pathway protects against acute pancreatitis via suppressing acinar cell ferroptosis
Qi Peng, Guoyong Hu* (Shanghai General Hospital, China)

十、临床药代动力学 (2024年第63卷第10期)

October 2024 -Volume 63 - Issue 10 (2024年10月第63卷第10期)
https://link.springer.com/journal/40262/volumes-and-issues/63-10

Review Article（综述文章）
1. 药效学在推进抗体药物偶联物临床研究中的应用：原理和建模策略
Application of Pharmacometrics in Advancing the Clinical Research of Antibody-Drug Conjugates: Principles and Modeling Strategies
Xiuqi Li, Hongyun Wang* (Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China)
2. 利用稳定铁同位素技术评估人体铁动力学
Assessing Human Iron Kinetics Using Stable Iron Isotopic Techniques
Nicole U. Stoffel* (ETH Zurich, Switzerland)
Systematic Review（系统综述）
3. 他克莫司的模型指导精准剂量：人群药动学模型的系统综述和软件工具的基准研究
Model-Informed Precision Dosing of Tacrolimus: A Systematic Review of Population Pharmacokinetic Models and a Benchmark Study of Software Tools
Yannick Hoffert, Erwin Dreesen* (KU Leuven, Belgium)
Original Research Article（原创研究文章）
4. 评估针对丙酮酸羧化酶的肝脏靶向抑制剂Firsocostat的细胞色素P450和转运蛋白介导的药物-药物相互作用的潜力
Evaluation of the Potential for Cytochrome P450 and Transporter-Mediated Drug–Drug Interactions for Firsocostat, a Liver-Targeted Inhibitor of Acetyl-CoA Carboxylase
Elijah J. Weber, Ahmed A. Othman* (Gilead Sciences, Inc., USA)
5. 基于生理的药动学建模评估总和游离丙戊酸在有无低白蛋白血症儿童中的剂量
Physiologically-Based Pharmacokinetic Modeling of Total and Unbound Valproic Acid to Evaluate Dosing in Children With and Without Hypoalbuminemia
Eleni Karatza, Daniel Gonzalez* (Janssen Research & Development, LLC, USA; Duke University School of Medicine, USA)
6.选择最佳的药动学模型进行模型集成的先验模型指导精准剂量
Selecting the Best Pharmacokinetic Models for a Priori Model-Informed Precision Dosing with Model Ensembling
Bram C. Agema, Sebastiaan D. T. Sassen* (Erasmus MC Cancer Institute, Erasmus University Medical Center, The Netherlands; Rotterdam Clinical Pharmacometrics Group, The Netherlands)
7.使用PK/PD模型为3期试验中的2型糖尿病患者选择Cetagliptin剂量
Use of a PK/PD Model to Select Cetagliptin Dosages for Patients with Type 2 Diabetes in Phase 3 Trials
Jinmiao Lu* (CGeneTech (Suzhou, China) Co., Ltd., China)
8.健康受试者和乳腺癌或结直肠癌患者的Tucatinib人群药动学分析
Population Pharmacokinetic Analysis of Tucatinib in Healthy Participants and Patients with Breast Cancer or Colorectal Cancer
Daping Zhang, Ariel Topletz-Erickson* (Pfizer Inc., USA)
9.Zilovertamab Vedotin在血液恶性肿瘤患者中的序贯人群药动学模型外推至儿童人群
A Sequential Population Pharmacokinetic Model of Zilovertamab Vedotin in Patients with Hematologic Malignancies Extrapolated to the Pediatric Population
Thijs J. Zweers, Manash S. Chatterjee* (Certara Inc, USA; Quantitative Pharmacology and Pharmacometrics, Merck & Co., Inc., USA)
10.卡利拉嗪与中度CYP3A4抑制剂联合用于精神分裂症患者：剂量调整和安全监测的含义
Coadministration of Cariprazine with a Moderate CYP3A4 Inhibitor in Patients with Schizophrenia: Implications for Dose Adjustment and Safety Monitoring
Máté Szabó* (Gedeon Richter Plc, Hungary)