一、April 2023 Volume 180 Issue 7（2023年4月第180卷第7期）
https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2023/180/7

      Editorial（社论）
      1. 阿片类药物危机时期的阿片类研究
    （Opioid research in the time of the opioid crisis）
      作者：John R. Traynor (Department of Pharmacology and Edward F. Domino Research Center, University of Michigan, USA)

      Themed Issue Review（重要议题综述）
      1. 芬太尼的异常药理学
    （The anomalous pharmacology of fentanyl）
      作者：Eamonn Kelly (School of Physiology, Pharmacology and Neuroscience, University of Bristol, UK)

      2. 了解和对抗阿片类药物引起的呼吸抑制
    （Understanding and countering opioid-induced respiratory depression）
      作者：Jordan T. Bateman, Erica S. Levitt* (Department of Pharmacology & Therapeutics, University of Florida, USA)

      3. 苯二氮卓类药物与羟考酮的离体代谢相互作用和动物模型中取决于使用模式的毒性
    （Metabolic interactions of benzodiazepines with oxycodone ex vivo and toxicity depending on usage patterns in an animal model）
      作者：Roland Lawson, Souleiman El Balkhi* (University of Limoges, France; Department of Pharmacology, Toxicology and Pharmacovigilance, France)

      4. 中枢代谢是小鼠吗啡镇痛感受性别差异的潜在来源，但不是镇痛耐受诱导的原因
    （Central metabolism as a potential origin of sex differences in morphine antinociception but not induction of antinociceptive tolerance in mice）
      作者：Florian Gabel, Yannick Goumon* (CNRS UPR3212, Institut des Neurosciences Cellulaires et Intégratives, France)

      Un-commissioned Review Artical-Themed Issue（未经委托的评论文章主题）
      1. 深入了解阿片类药物使用障碍的潜在机制和潜在的治疗策略
    （Insights into the mechanisms underlying opioid use disorder and potential treatment strategies）
      作者：Dan-Ni Cao, Ning Wu*, Jin Li* (Beijing Key Laboratory of Neuropsychopharmacology, China)

      Themed Issue Review（重要议题综述）
      1. 双脑啡肽酶抑制剂抑制脑啡肽分解代谢：一种治疗阿片类药物使用障碍的新方法
    （The inhibition of enkephalin catabolism by dual enkephalinase inhibitor: A novel possible therapeutic approach for opioid use disorders）
      作者：Beltran Alvarez-Perez, Rafael Maldonado* (Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Pompeu Fabra University, Spain)

      2. 阿片类药物流行期间通过内源性大麻素替代性疼痛管理：外周神经调控和药物干预
    （Alternative pain management via endocannabinoids in the time of the opioid epidemic: Peripheral neuromodulation and pharmacological interventions）
      作者：Ming Tatt Lee, Lih-Chu Chiou* (Department and Graduate Institute of Pharmacology, National Taiwan University, Taiwan)

      3. 与持续自我给药相比，间歇性给药的海洛因摄入量增加和复发脆弱性：大鼠的性别差异
    （Increased heroin intake and relapse vulnerability in intermittent relative to continuous self-administration: Sex differences in rats）
      作者：Ginevra D'Ottavio, Daniele Caprioli* (Laboratory affiliated to Institute Pasteur Italia-Fondazione Cenci Bolognetti-Department of Physiology and Pharmacology, Sapienza University of Rome, Italy)

      4. G蛋白信号传导调节因子4（RGS4）负调控伤害肽/孤啡肽FQ阿片受体信号传导：对l-多巴胺诱导的运动障碍的意义
    （Regulator of G-Protein Signalling 4 (RGS4) negatively modulates nociceptin/orphanin FQ opioid receptor signalling: Implication for l-Dopa-induced dyskinesia）
      作者：Clarissa A. Pisanò, Michele Morari* (Department of Neuroscience and Rehabilitation, University of Ferrara, Italy)

      5. μ阿片受体上一种新的G蛋白偏向激动剂通过G蛋白偶联受体激酶诱导大量受体脱敏
    （A novel G protein-biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein-coupled receptor kinase）
      作者：Sam Groom, Chris P. Bailey* (Department of Pharmacy and Pharmacology, University of Bath, UK)

      6. 远端局部光激活吗啡产生镇痛作用而无阿片类药物相关的不良反应
    （Remote local photoactivation of morphine produces analgesia without opioid-related adverse effects）
      作者：Marc López-Cano,  Amadeu Llebaria* (Pharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Spain; MCS, Laboratory of Medicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Spain)

      7. 实现更安全的阿片类止痛药的策略——对旧的和即将到来的目标的回顾
    （Strategies towards safer opioid analgesics—A review of old and upcoming targets）
      作者：Balazs R. Varga¹, John M. Streicher²*, Susruta Majumdar¹* (Center for Clinical Pharmacology, University of Health Sciences and Pharmacy in St. Louis and Washington University School of Medicine, USA; Department of Pharmacology, College of Medicine, University of Arizona, USA)

      8. 实现更安全的阿片类止痛药的策略——对旧的和即将到来的目标的回顾
    （Strategies towards safer opioid analgesics—A review of old and upcoming targets）
      作者：Balazs R. Varga¹, John M. Streicher²*, Susruta Majumdar¹* (1. Center for Clinical Pharmacology, University of Health Sciences and Pharmacy, USA; 2. Department of Pharmacology, College of Medicine, University of Arizona, USA)

二、April2023 Volume180 Issue8（2023年4月第180卷第8期）
https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2023/180/8

      Review article（综述文章）
      1. 急性T淋巴细胞白血病的发病机制及靶向药物的开发
    （The pathogenesis and development of targeted drugs in acute T lymphoblastic leukaemia）
      作者：Zhaoying Chen, Wei Wei*, Yujing Wu* (Institute of Clinical Pharmacology, Anhui Medical University, China)

      Research Articles（研究）
      1. 艾司利卡西平（S-licarbaezepine）作为一种潜在的精确疗法对引起神经精神障碍的SCN8A变体的体外作用
    （In vitro effects of eslicarbazepine (S-licarbazepine) as a potential precision therapy on SCN8A variants causing neuropsychiatric disorders）
      作者：Erva Bayraktar, Thomas V. Wuttke*, Stephan Lauxmann* (Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, Germany)

      2. 半日花烷二萜类化合物Calcaratarin D通过调节肺泡巨噬细胞功能减轻小鼠哮喘
    （Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function）
      作者：Wupeng Liao, Wai Shiu Fred Wong* (Department of Pharmacology, Yong Loo Lin School of Medicine, Singapore)

      3. 类黄酮GL-V9通过调节活化肝星状细胞中的转录因子GATA4触发衰老来减轻肝纤维化
    （The flavonoid GL-V9 alleviates liver fibrosis by triggering senescence by regulating the transcription factor GATA4 in activated hepatic stellate cells）
      作者：Jiawei Zhao¹, Lulu Zhang²*, Yue Zhao¹*, Na Lu¹* (1. State Key Laboratory of Natural Medicines, China; 2. Department of Clinical Pharmacology, School of Pharmacy, Nanjing Medical University, China)

      4. 海马小胶质细胞的不对称激活导致啮齿动物三叉神经痛的焦虑抑制后果
    （Asymmetric activation of microglia in the hippocampus drives anxiodepressive consequences of trigeminal neuralgia in rodents）
      作者：Li-Qiang Chen (State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, China)

      5. Licochalcone A通过与髓系分化因子2（MD2）直接结合，预防LPS诱导的炎症和急性肺损伤
    （Licochalcone A protects against LPS-induced inflammation and acute lung injury by directly binding with myeloid differentiation factor 2 (MD2)）
      作者：Weiwei Zhu¹, Joo Young Huh²*, Guang Liang¹*, Yi Wang¹* (1. Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, China; 2. College of Pharmacy, Chonnam National University, Korea)

      6. 化疗诱导的通过GBP5/NLRP3炎症小体轴的静脉炎和七叶皂苷的治疗作用
    （Chemotherapy-induced phlebitis via the GBP5/NLRP3 inflammasome axis and the therapeutic effect of aescin）
      作者：Peng Liu¹, Zhou Lan²*, Jing Feng³*, Lvyi Chen¹* (1. School of Pharmaceutical Sciences, South-Central Minzu University, China; 2. School of Pharmacy, Hubei University of Chinese Medicine, China; 3. Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China)

      7. 在TRPV1伤害感受器致敏过程中，sigma-1受体抑制内源性阿片类镇痛
    （The sigma-1 receptor curtails endogenous opioid analgesia during sensitization of TRPV1 nociceptors）
      作者：M. Carmen Ruiz-Cantero, Enrique J. Cobos* (Department of Pharmacology, Faculty of Medicine, University of Granada, Spain)

      8. Curaxin CBL0137通过抑制Src-YAP信号轴抑制内皮炎症和动脉粥样硬化形成
    （Curaxin CBL0137 inhibits endothelial inflammation and atherogenesis via suppression of the Src-YAP signalling axis）
      作者：Huanyu Ding¹, Li Wang²*, Yu Huang¹* (1. School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, China; 2. Department of Biomedical Sciences, City University of Hong Kong, China)