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国际TOP10药学期刊文章信息 (2023年11月)

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一、临床药理学与治疗学 (2023年第114卷第5期)

November 2023 - Volume 114 - Issue 5 (2023年11月第114卷第5期)

1. 大麻素疗法的临床药理学:药物相互作用和副作用
(Clinical Pharmacology of Cannabinoid Therapeutics: Drug Interactions and Side Effects)
作者:Ingolf Cascorbi* (Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Germany)

1. 模型引导的药物发展:迈向统一指南
(Model-Informed Drug Development: Steps Toward Harmonized Guidance)
作者:Scott Marshall* (Clinical Pharmacology Modelling and Simulation, GSK, UK)

1. 以生理学为基础的儿科患者用药剂量的药代动力学模型:临床监护的实用方法教程
(Physiologically-Based Pharmacokinetic Modeling for Drug Dosing in Pediatric Patients: A Tutorial for a Pragmatic Approach in Clinical Care)
作者:Joyce E. M. van der Heijden* (Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, The Netherlands)

1. 基于多模式人工智能的目标选择和临床试验设计的临床试验结果预测
(Prediction of Clinical Trials Outcomes Based on Target Choice and Clinical Trial Design with Multi-Modal Artificial Intelligence)
作者:Alex Aliper, Alex Zhavoronkov* (Insilico Medicine AI Ltd, United Arab Emirates)
2. SURF:用于评估在FDA申请中使用真实数据支持有效性声明是否具有监管可行性的筛选工具(供申办者使用)
(SURF: A Screening Tool (for Sponsors) to Evaluate Whether Using Real-World Data to Support an Effectiveness Claim in an FDA Application Has Regulatory Feasibility)
作者:Ulka B. Campbell* (Aetion, Inc., USA)
3. 推进个体化治疗的多方利益相关者视角
(A Multistakeholder Perspective on Advancing Individualized Therapeutics)
作者:Michael Pacanowski* (U.S. FDA, Center for Drug Evaluation and Research, Office of Translational Sciences, Office of Clinical Pharmacology, USA)

1. 真实世界证据在神经科学相关新药和生物制剂新疗法许可证申请中的应用
(Use of Real-World Evidence in Neuroscience-Related New Drug and Biologics License Applications for Novel Therapeutics)
作者:Bartholt Bloomfield-Clagett, John Concato* (Center for Drug Evaluation and Research, FDA, USA)
2. 使用定量系统毒理学评估大麻二酚和丙戊酸单独和联合用药对肝脏的影响
(Assessing Liver Effects of Cannabidiol and Valproate Alone and in Combination Using Quantitative Systems Toxicology)
作者:Vinal V. Lakhani, Paul B. Watkins* (DILIsym Services Inc., A Simulations-Plus Company, USA; UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA)
3. 定量系统毒理学鉴定AKR1C3抑制剂BAY1128688引起的肝毒性和胆红素升高的独立机制
(Quantitative Systems Toxicology Identifies Independent Mechanisms for Hepatotoxicity and Bilirubin Elevations Due to AKR1C3 Inhibitor BAY1128688)
作者:Christina Battista* (DILIsym Services division, Simulations Plus, Inc., USA)
4. CYP2C的巨大影响:TG单倍型对体内CYP2C19底物清除、蛋白含量和体外活性的影响
(Impact of CYP2C:TG Haplotype on CYP2C19 Substrates Clearance In Vivo, Protein Content, and In Vitro Activity)
作者:Pablo Zubiaur* (Clinical Pharmacology Department, Hospital Universitario de La Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Spain)
5. 欧洲药品管理局肿瘤业务研发管线进度会议期间提出的问题:5年回顾性分析
(Queries Raised During Oncology Business Pipeline Meetings at the European Medicines Agency: A 5-Year Retrospective Analysis)
作者:C. Mircea S. Tesileanu, Enrico Tognana* (Oncology and Hematology Office, European Medicines Agency, The Netherlands; Regulatory Science and Innovation Task Force, European Medicines Agency, The Netherlands)
6. 加巴喷丁和阿片类药物的同时使用与非癌性疼痛的老年医疗保险受益人的死亡率风险
(Concurrent Gabapentin and Opioid Use and Risk of Mortality in Medicare Recipients with Non-Cancer Pain)
作者:Meghan A. Corriere, Cecilia P. Chung* (Department of Medicine, Vanderbilt University Medical Center, USA)
7. 对先前提出的肾脏转运蛋白介导的药物相互作用的23种生物标志物的敏感性和特异性的代谢组学分析
(A Metabolomic Analysis of Sensitivity and Specificity of 23 Previously Proposed Biomarkers for Renal Transporter-Mediated Drug-Drug Interactions)
作者:Arne Gessner* (Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany)
8. 补充随机临床试验的真实世界证据:托珠单抗治疗重症COVID-19肺炎与接受标准治疗的队列
(Real-World Evidence to Supplement Randomized Clinical Trials: Tocilizumab for Severe COVID-19 Pneumonia vs. a Cohort Receiving Standard of Care)
作者:Jacek Skarbinski* (Division of Research, Kaiser Permanente Northern California, USA)
9. 急性淋巴细胞白血病AIEOP-BFM ALL 2009方案中巯嘌呤代谢产物对疾病结果的影响
(Impact of Mercaptopurine Metabolites on Disease Outcome in the AIEOP-BFM ALL 2009 Protocol for Acute Lymphoblastic Leukemia)
作者:Raffaella Franca, Gabriele Stocco* (Department of Medical, Surgical and Health Sciences, University of Trieste, Italy)
10. TRPA1拮抗剂LY3526318抑制肉桂醛引起的皮肤血流量增加:药理学的转化证明
(TRPA1 Antagonist LY3526318 Inhibits the Cinnamaldehyde-Evoked Dermal Blood Flow Increase: Translational Proof of Pharmacology)
作者:Dorien Bamps* (Department of Pharmaceutical and Pharmacological Sciences, Center for Clinical Pharmacology, Belgium)
11. 高血小板反应性联合CYP2C19基因型预测接受经皮冠状动脉介入治疗的东亚患者的预后
(High Platelet Reactivity Combined with CYP2C19 Genotype in Predicting Outcomes in East Asian Patients Undergoing Percutaneous Coronary Intervention)
作者:Se-Eun Kim, Young-Hoon Jeong*, Sung Gyun Ahn* (Division of Cardiology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, Korea)
(Comparison of EHR Data-Completeness in Patients with Different Types of Medical Insurance Coverage in the United States)
作者:Priyanka Anand, Kueiyu Joshua Lin* (Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, USA)
(CYP2C19 Loss-of-Function Variants Associated With Long-Term Ischemic Stroke Events During Clopidogrel Treatment in the Chinese Population)
作者:Peng Wu, Tao Xu*, Kaixin Zhou* (Guangzhou Laboratory, Guangzhou International Bio Island, China)
(Effect of Omeprazole Administration on the Pharmacokinetics of Oral Extended-Release Nifedipine in Healthy Subjects)
作者:Liang Zhao* (Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, FDA, USA)


November 2023 - Volume 75 - Issue 6 (2023年11月第75卷第6期)

IUPHAR Nomenclature(IUPHAR(国际药理联合组织)命名法)
1. 国际基础与临床药理学联合会CXIII:核受体超家族-2023更新
(International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023)
作者:Thomas P. Burris

Review Articles(综述文章)
(Oxycodone: A Current Perspective on Its Pharmacology, Abuse, and Pharmacotherapeutic Developments)
作者:James E. Barrett (Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University. Pennsylvania)
(Optical Approaches for Investigating Neuromodulation and G Protein–Coupled Receptor Signaling)
作者:David J. Marcus (Center for the Neurobiology of Addiction, Pain and Emotion, Department of Anesthesiology and Pain Medicine, University of Washington, Washington)
(Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming)
作者:Jericho Wee (Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, Singapore)
(Therapeutic Potential of Targeting Prokineticin Receptors in Diseases)
作者:Martina Vincenzi (Regenerative Nanomedicine (UMR 1260), INSERM, University of Strasbourg, Center of Research in Biomedicine of Strasbourg, France)
(Lymphocyte Depleting and Modulating Therapies for Chronic Lung Allograft Dysfunction)
作者:Saskia Bos (Newcastle University Translational and Clinical Research Institute, UK)
(Targeting Epidermal Growth Factor Receptor for Cancer Treatment: Abolishing Both Kinase-Dependent and Kinase-Independent Functions of the Receptor)
作者:Yuesheng Zhang (Department of Pharmacology and Toxicology, School of Medicine, and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Virginia)

三、先进药物输送评论 (2023年第202卷)

November 2023 - Volume 202 (2023年11月第202卷)

1. 社论:眼部药物递送-挑战、机遇和发展
(Editorial: Ocular drug delivery - Challenges, opportunities, and developments)
作者:Jian Ji (MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, China)
2. 溶酶体治疗和药物递送策略:综述
(Lysosomal therapies and drug delivery strategies: An overview)
作者:Silvia Muro (Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute for Science and Technology (BIST), Spain)

Review article(综述文章)
1. 用于癌症微创局部免疫治疗的水凝胶给药系统
(Hydrogel drug delivery systems for minimally invasive local immunotherapy of cancer)
作者:Andrew S. Mikhail* (Center for Interventional Oncology, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, USA)
2. 口服药物制剂中表面活性剂辅料的安全性
(Safety of surfactant excipients in oral drug formulations)
作者:Sam Maher* (School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Ireland)
3. 革命性的药物配方开发:机器学习日益增长的影响
(Revolutionizing drug formulation development: The increasing impact of machine learning)
作者:Zeqing Bao, Pauric Bannigan*, Christine Allen* (Leslie Dan Faculty of Pharmacy, University of Toronto, Canada)
4. 细胞内药物膜聚集体和细胞器内小分子药物沉淀物的定量拉曼化学成像
(Quantitative Raman chemical imaging of intracellular drug-membrane aggregates and small molecule drug precipitates in cytoplasmic organelles)
作者:Vernon LaLone, Gus R. Rosania* (Cambium Analytica Research Laboratories, USA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, USA)
5. 利用吸入纳米颗粒克服呼吸道疾病治疗的肺屏障
(Harnessing inhaled nanoparticles to overcome the pulmonary barrier for respiratory disease therapy)
作者:Zhaokui Jin, Weisheng Guo*, Xing-Jie Liang* (School of Biomedical Engineering, Guangzhou Medical University, China)
6. 脑靶向纳米载体的蛋白冠:挑战与前景
(Protein corona on brain targeted nanocarriers: Challenges and prospects)
作者:Kuan Jiang, Huiping Lu* (Eye Institute and Department of Ophthalmology, Eye and ENT Hospital & Department of Pharmacology, School of Basic Medical Sciences & State Key Laboratory of Molecular Engineering of Polymers, Fudan University, China; Department of Pharmacy, Shanghai Pudong Hospital, Fudan University Pudong Medical Center & School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, China)
7. 基于脂质双层用于声动力癌症治疗的生物纳米平台
(Lipid bilayer-based biological nanoplatforms for sonodynamic cancer therapy)
作者:Songhao Li, Yunlu Dai* (Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, China)

四、药理学发展趋势 (2023年第44卷第11期)

November 2023 - Volume 44 - Issue 11 (2023年11月第44卷第11期)

1. 推进靶向蛋白质降解模式
(Advancing targeted protein degradation modalities)
作者:Jerry C. Madukwe

1. 靶向蛋白质降解方法的前景
(The promise of targeted protein degradation approaches)
作者:Danette L. Daniels* (Foghorn Therapeutics, USA)

1. 照亮肿瘤毁灭之路
(Lighting the way to tumor destruction)
作者:Christina C. Kuismi, Behnam Nabet* (Human Biology Division, Fred Hutchinson Cancer Center, USA)
2. 战术上回应,战略上贬低
(ReSPONDINg TACtically, degrading strategically)
作者:Breanna L. Zerfas* (Center for Protein Degradation, Dana-Farber Cancer Institute, USA)
3. 表面粘蛋白的剪切削弱了肿瘤细胞的强度
(Shearing of surface mucin saps tumor cell strength)
作者:Liza J. Greenberg, Deborah Fass* (Bronx High School of Science, USA; Weizmann Institute of Science, Israel)

1. 利用UBR5靶向蛋白降解关键转录调控因子
(Harnessing UBR5 for targeted protein degradation of key transcriptional regulators)
作者:Asad M. Taherbhoy, Danette L. Daniels* (Foghorn Therapeutics, 500 Technology Square Suite 700, USA)

1. 细胞外分泌蛋白和膜蛋白的靶向降解
(Targeted degradation of extracellular secreted and membrane proteins)
作者:Xuankun Chen, Weiping Tang* (Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin–Madison, USA)
2. 利用适配子进行靶向蛋白质降解
(Leveraging aptamers for targeted protein degradation)
作者:Zhihao Yang, Chenghao Xuan* (The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Biochemistry and Molecular Biology, Tianjin Medical University, China)
3. 蛋白质组学方法促进靶向蛋白质降解
(Proteomic approaches advancing targeted protein degradation)
作者:Gajanan Sathe* (MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, UK)
4. 靶向非半胱氨酸残基的共价片段路径
(Covalent fragment approaches targeting non-cysteine residues)
作者:Noémi Csorba, György M. Keserű* (Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Hungary)
5. 通过编码双显示技术推进小分子药物发现
(Advancing small-molecule drug discovery by encoded dual-display technologies)
作者:Alice Lessing, Dimitar Petrov, Jörg Scheuermann* (ETH Zürich, Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Switzerland)
6. 肿瘤中NK细胞活性和行为的代谢适应:挑战和治疗机会
(Metabolic adaptation of NK cell activity and behavior in tumors: challenges and therapeutic opportunities)
作者:Shambhavi Borde, Sandro Matosevic* (Department of Industrial and Physical Pharmacy, Purdue University, USA)

五、药理学与治疗学 (2023年第251卷)

November 2023 - Volume 251 (2023年11月第251卷)

Review article(综述文章)
1. 免疫细胞在子宫内膜肿瘤微环境中的作用和参与方式
(The role and participation of immune cells in the endometrial tumor microenvironment)
作者:Debasish Kumar Dey, Vishal Chandra* (Gynecologic Oncology Section, Obstetrics and Gynecology Department, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, USA)
2. 核受体功能受损和代谢失调在威尔逊氏病中的治疗意义
(Therapeutic implications of impaired nuclear receptor function and dysregulated metabolism in Wilson's disease)
作者:Clavia Ruth Wooton-Kee* (Baylor College of Medicine, Department of Pediatrics-Nutrition, Children's Nutrition Research Center, USA)
3. 调节糖皮质激素受体在生理和病理中的作用:来自共调节因子的见解
(Modulating glucocorticoid receptor actions in physiology and pathology: Insights from coregulators)
作者:Lina Fadel, Inez Rogatsky* (Institute for Diabetes and Endocrinology IDE, Helmholtz Munich, Germany; Hospital for Special Surgery Research Institute, The David Rosenzweig Genomics Center, USA)
4. 蛋白肽和糖蛋白在生理和疾病中的硫基偶联
(Sulfoconjugation of protein peptides and glycoproteins in physiology and diseases)
作者:Pengfei Xu, Wen Xie* (Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, USA)
5. 痛觉中的突触前谷氨酸受体
(Presynaptic glutamate receptors in nociception)
作者:Rou-Gang Xie* (Department of Neurobiology, Fourth Military Medical University, China)
6. 脑缺血中的信号通路:机制和治疗意义
(Signaling pathways in brain ischemia: Mechanisms and therapeutic implications)
作者:Wen Lin, Xiang-Yu Zhao, Yi-Xuan Zhang* (Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, China; International Joint Laboratory for Drug Target of Critical Illnesses, Key Laboratory of Cardiovascular and Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, China)
7. 神经性疼痛:从实际药理学治疗到新的治疗视野
(Neuropathic pain: From actual pharmacological treatments to new therapeutic horizons)
作者:Maxime Thouaye, Ipek Yalcin* (Centre National de la Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, France)
8. 组蛋白和非组蛋白在表观遗传调控中的翻译后修饰及其在酒精相关肝病中的翻译后修饰应用:挑战和研究机遇
(Post-translational modifications of histone and non-histone proteins in epigenetic regulation and translational applications in alcohol-associated liver disease: Challenges and research opportunities)
作者:Wiramon Rungratanawanich, James P. Hardwick* (Section of Molecular Pharmacology and Toxicology, National Institute on Alcohol Abuse and Alcoholism, USA; Department of Integrative Medical Sciences, Northeast Ohio Medical University, USA)
9. 严重高甘油三酯血症:现有和新兴的治疗方法
(Severe hypertriglyceridemia: Existing and emerging therapies)
作者:Waqas A. Malick, Robert S. Rosenson* (Metabolism and Lipids Program, The Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, USA)
10. 硼在癌症治疗中的应用:综述
(Boron in cancer therapeutics: An overview)
作者:Swanand Kulkarni, Dyuti Bhandary, Suresh Thareja* (Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, India)
11. NLRP3与癌症:发病机制和治疗机会
(NLRP3 and cancer: Pathogenesis and therapeutic opportunities)
作者:Isak W. Tengesdal, Carlo Marchetti* (Department of Medicine, University of Colorado Denver, USA)
12. 肥胖及其合并症,目前的治疗方案和未来前景:挑战减重手术?
(Obesity and its comorbidities, current treatment options and future perspectives: Challenging bariatric surgery?)
作者:Simon Kloock, Ulrich Dischinger* (Department of Internal Medicine, Division of Endocrinology and Diabetes, University Hospital, University of Würzburg, Germany)

六、药物 (2023年第83卷第16期)

November 2023 - Volume 83 - Issue 16 (2023年11月第83卷第16期)

Leading Article(主编文章)
1. 酒精相关肝病:不断发展的概念和临床治疗
(Alcohol-Associated Liver Disease: Evolving Concepts and Treatments)
作者:David Stephen Prince* (AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Australia)

Review Article(综述文章)
1. 当前补体蛋白作为免疫球蛋白A肾病治疗靶点的研究进展
(Current Understanding of Complement Proteins as Therapeutic Targets for the Treatment of Immunoglobulin A Nephropathy)
作者:Arun Rajasekaran, Dana V. Rizk* (Division of Nephrology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, USA)
2. 新兴的降尿酸药物和痛风的药物治疗策略:一份叙述性综述
(Emerging Urate-Lowering Drugs and Pharmacologic Treatment Strategies for Gout: A Narrative Review)
作者:Robert Terkeltaub* (Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California, USA)

Systematic Review(系统综述)
1. 急诊科肌肉骨骼疼痛患者使用阿片类药物后的持续阿片类药物使用和不良事件:一项系统综述和Meta分析
(Continued Opioid Use and Adverse Events Following Provision of Opioids for Musculoskeletal Pain in the Emergency Department: A Systematic Review and Meta-Analysis)
作者:Qiuzhe Chen* (Institute for Musculoskeletal Health, The University of Sydney and Sydney Local Health District, Australia)

AdisInsight Report(AdisInsight报告)
1. 0.25%洛替拉纳滴眼液:首次获批
(Lotilaner Ophthalmic Solution 0.25%: First Approval)
作者:Yahiya Y. Syed* (Springer Nature, New Zealand)
(Tafolecimab: First Approval)
作者:Susan J. Keam (Springer Nature, New Zealand)
(Pozelimab: First Approval)
作者:Sheridan M. Hoy (Springer Nature, New Zealand)
(Zuranolone : First Approval)
作者:Young-A Heo (Springer Nature, New Zealand)

七、药理学研究 (2023年第197卷)

November 2023 - Volume 197 (2023年11月第197卷)

Review Articles(综述文章)
1. 黄金香料姜黄素靶向内皮细胞:一种治疗心脏代谢多发性疾病的有前景疗法
(Targeting endothelial cells with golden spice curcumin: A promising therapy for cardiometabolic multimorbidity)
作者:Fei Tang, Hui Ao* (Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, China)

2. 色氨酸代谢沿微生物-肠-脑轴在苯丙酮尿症的认知和行为方面可能产生的作用
(Possible role of tryptophan metabolism along the microbiota-gut-brain axis on cognitive & behavioral aspects in Phenylketonuria)
作者:Sara Parolisi, Elvira Verduci* (UOSD Metabolic Diseases, AORN Santobono-Pausilipon, Italy; Department of Pediatrics, Vittore Buzzi Children’s Hospital, University of Milan, Italy)
3. 松果菊苷:一种很有前景的活性天然产物和药理制剂
(Echinacoside: A promising active natural products and pharmacological agents)
作者:Wang Wang, Yang Zhao*, Guoxue Zhu* (Department of Neurology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, China)
4. CircRNA在眼部新生血管疾病中的作用:基础机制和临床潜力
(CircRNA in ocular neovascular diseases: Fundamental mechanism and clinical potential)
作者:Wenxin Zhang, Yuxi He, Yan Zhang* (Department of Ophthalmology, 2nd Hospital of Jilin University, China)
5. IUPHAR主题综述:阿片类药物的疗效、偏倚和选择性
(IUPHAR themed review: Opioid efficacy, bias, and selectivity)
作者:Nokomis Ramos-Gonzalez, Susruta Majumdar* (Department of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, USA)
6. 肾脏疾病中蛋白质乙酰化及相关的潜在治疗策略
(Protein acetylation and related potential therapeutic strategies in kidney disease)
作者:Xiang-yu Li, Wei Shao* (Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, the Key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, China; School of Basic Medicine, Anhui Medical University, China)
7. 细胞焦亡在HIV感染者不完全免疫重建中的作用:潜在的治疗靶点
(The role of pyroptosis in incomplete immune reconstitution among people living with HIV:Potential therapeutic targets)
作者:Chao Xia, Jing Ouyang* (Clinical Research Center, Chongqing Public Health Medical Center, China)
8. IUPHAR综述-二价体和双功能阿片受体配体用作新型镇痛剂
(IUPHAR Review - Bivalent and bifunctional opioid receptor ligands as novel analgesics)
作者:Kyle J. Rehrauer, Christopher W. Cunningham* (Department of Pharmaceutical and Administrative Sciences, Concordia University Wisconsin School of Pharmacy, USA)
9. 可溶性鸟苷酸环化酶:治疗血管性认知障碍的新靶点?
(Soluble guanylyl cyclase: A novel target for the treatment of vascular cognitive impairment?)
作者:Ellis Nelissen* (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Maastricht University, the Netherlands)
10. 肠道炎症的Eph/ephrin系统交响乐
(The Eph/ephrin system symphony of gut inflammation)
作者:Peishan Qiu, Lei Zhang* (Department of Gastroenterology, Zhongnan Hospital of Wuhan University, China; Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China)
11. α7烟碱型乙酰胆碱受体的离子移变和代谢型反应
(Ionotropic and metabotropic responses by alpha 7 nicotinic acetylcholine receptors)
作者:Patricia Sinclair, Nadine Kabbani* (Interdisciplinary Program in Neuroscience, USA)
12. 粘附GPCRs的分子内活性调控的最新结构和进化信息
(Intramolecular activity regulation of adhesion GPCRs in light of recent structural and evolutionary information)
作者:Gunnar Kleinau, Torsten Schöneberg* (Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Physics and Biophysics, Group Structural Biology of Cellular Signaling, Germany; Rudolf Schönheimer Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, Germany)
13. 脂氧素介导的信号传导:ALX/FPR2相互作用及其他
(Lipoxin-mediated signaling: ALX/FPR2 interaction and beyond)
作者:Sergio Sánchez-García, Lisardo Boscá* (Instituto de Investigaciones Biomédicas "Alberto Sols", CSIC-UAM Madrid, Spain)
14. 机器学习和深度学习在SPECT和PET成像中的应用:概述、挑战和未来展望
(Applications of machine learning and deep learning in SPECT and PET imaging: General overview, challenges and future prospects)
作者:Carmen Jimenez-Mesa, Juan Manuel Gorriz* (Department of Signal Theory, Networking and Communications, University of Granada, Spain)
15. 胆固醇酯转移蛋白抑制在心血管疾病之外不断演变的作用
(The evolving role of cholesteryl ester transfer protein inhibition beyond cardiovascular disease)
作者:Nehal Mehta, John J.P. Kastelein* (Mobius Scientific, Inc., USA; Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, the Netherlands)
16. 蝎毒肽:分子多样性,结构特征,以及从通道病变到病毒感染和癌症的治疗用途
(Scorpion venom peptides: Molecular diversity, structural characteristics, and therapeutic use from channelopathies to viral infections and cancers)
作者:Zhiqiang Xia, Hang Fai Kwok* (School of Biological and Food Processing Engineering, Huanghuai University, China; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Avenida de Universidade, China)

Research article(研究文章)
(Super-enhancer-associated SNHG15 cooperating with FOSL1 contributes to bladder cancer progression through the WNT pathway)
作者:Mingyue Tan, Dingguo Zhang* (Department of Urology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, China; Department of Urology, Shanghai Pudong New Area People's Hospital, China)
2. 新型间皮素靶向嵌合抗原受体修饰的UNKT细胞可高效抑制肿瘤进展
(Novel mesothelin-targeted chimeric antigen receptor-modified UNKT cells are highly effective in inhibiting tumor progression)
作者:Wei Jiang, Weidong Xu* (Biotherapy Center, Harbin Medical University Cancer Hospital, China; Abelow Pharmaceuticals Inc., 10 Xinghuo Road, Jiangbei New Area, China)
3. 参加U-PGx PREPARE研究的结直肠癌患者药物基因组学指导治疗的成本-效用分析和跨国比较
(Cost-utility analysis and cross-country comparison of pharmacogenomics-guided treatment in colorectal cancer patients participating in the U-PGx PREPARE study)
作者:Vasileios Fragoulakis, Christina Mitropoulou* (The Golden Helix Foundation, UK)
4. C4BP(β-)介导的免疫调节可减轻dss诱导的小鼠结肠炎和IBD患者的髓系细胞炎症
(C4BP(β-)-mediated immunomodulation attenuates inflammation in DSS-induced murine colitis and in myeloid cells from IBD patients)
作者:Inmaculada Serrano, Ana Luque, Josep M. Aran* (Immune-inflammatory Processes and Gene Therapeutics Group, Bellvitge Institute for Biomedical Research (IDIBELL), L’Hospitalet de Llobregat, Spain)
5. 利用红细胞源性囊泡通过线粒体依赖性细胞死亡来克服耐药癌症的溶酶体靶向阿霉素递送
(Lysosomal-targeted doxorubicin delivery using RBC-derived vesicles to overcome drug-resistant cancer through mitochondrial-dependent cell death)
作者:Chih-Peng Lin, Dong-Ming Huang* (Department of Anesthesiology, National Taiwan University Hospital and College of Medicine, National Taiwan University, China; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, China)
6. 骨痛贴片与非甾体抗炎药治疗膝骨关节炎的疗效和安全性比较:中国一项真实世界多中心前瞻性队列研究
(Efficacy and safety of Gutong Patch compared with NSAIDs for knee osteoarthritis: A real-world multicenter, prospective cohort study in China)
作者:Yingjie Wang, Tian Li* (Department of Orthopedic Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, China; School of Basic Medicine, Fourth Military Medical University, China)
7. 粉防己碱与MAPK抑制剂协同调节TRAIL -死亡受体轴,治疗KRAS突变型胰腺导管腺癌
(Tetrandrine synergizes with MAPK inhibitors in treating KRAS-mutant pancreatic ductal adenocarcinoma via collaboratively modulating the TRAIL-death receptor axis)
作者:Shuai Tang, Meiyu Geng* (School of Chinese Materia Medica, Nanjing University of Chinese Medicine, China)
8. 免疫药理学的性别取向观点
(Sex-oriented perspectives in immunopharmacology)
作者:Andrea Cignarella* (Department of Medicine, University of Padova, Italy)
9. 通过神经元胰岛素样生长因子-1的血液外泌体感知调节自闭症相关表型
(Blood exosome sensing via neuronal insulin-like growth factor-1 regulates autism-related phenotypes)
作者:Lei Chen, Yang Du* (Key Laboratory of Ethnomedicine of Ministry of Education, Center on Translational Neuroscience, School of Pharmacy, Minzu University of China, China)
10. 补充海洋来源的n-3 PUFA对可溶性粘附分子的影响:随机对照试验的系统评价和剂量-反应Meta分析
(Effects of marine-derived n-3 PUFA supplementation on soluble adhesion molecules: A systematic review and dose-response meta-analysis of randomized controlled trials)
作者:Mahsa Shirani, Mohammad Bagherniya* (Student Research Committee, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Iran; Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Iran)
11. 缺氧诱导的circSTT3A通过增强丝氨酸合成并促进H3K4me3修饰,促进乳腺癌干细胞形成
(Hypoxia-induced circSTT3A enhances serine synthesis and promotes H3K4me3 modification to facilitate breast cancer stem cell formation)
作者:Ming Xu, Yan Sun* (Key Laboratory of Laboratory Medical Diagnostics, Chinese Ministry of Education, Chongqing Medical University, China; Department of Cell Biology and Medical Genetics, Basic Medical School, Chongqing Medical University, China)
12. 来自深海真菌的青霉素肽A (PPA)通过激活AKT/GSK-3β/β-catenin信号通路,促进成骨细胞介导的骨形成,减轻卵巢切除术诱导的骨质流失
(Penicopeptide A (PPA) from the deep-sea-derived fungus promotes osteoblast-mediated bone formation and alleviates ovariectomy-induced bone loss by activating the AKT/GSK-3β/β-catenin signaling pathway)
作者:Chun-Lan Xie, Guang-Rong Ji* (Fujian Provincial Key Laboratory of Organ and Tissue Regeneration, School of Medicine, Xiamen University, China; Department of Orthopedics Surgery, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, China)
13. 面向真实世界的临床药理学:药物警戒、药物流行病学和药物经济学评估
(Clinical pharmacology facing the real-world setting: Pharmacovigilance, pharmacoepidemiology and the economic evaluation of drugs)
作者:Antonia Agustí, José A. Sacristán* (Clinical Pharmacology Service, Vall Hebron University Hospital and Department of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona, Spain; Medical Department, Lilly Spain, Spain)
14. CircIQGAP1通过ceRNA机制调控RCAN1和RCAN2,并促进恶性胶质瘤的生长
(CircIQGAP1 regulates RCAN1 and RCAN2 through the mechanism of ceRNA and promotes the growth of malignant glioma)
作者:Xiang Huang, You Lang Zhou* (Department of Neurosurgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, China; Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, China)
(Prescribing statin therapy in physically (in)active individuals vs prescribing physical activity in statin-treated patients: A four-scenario practical approach)
作者:Blanca Gavilán-Carrera, Alberto Soriano-Maldonado* (Department of Internal Medicine, Virgen de las Nieves University Hospital, Spain; Department of Education, Faculty of Education Sciences, University of Almería, Spain)
16. 在急性髓性白血病中,膳食γ-山竹素可触发免疫原性细胞死亡并激活cGAS信号
(Dietary γ-mangostin triggers immunogenic cell death and activates cGAS signaling in acute myeloid leukemia)
作者:Zi-Jie Long* (Department of Hematology, The Third Affiliated Hospital, Sun Yat-sen University, China)
17. 通过Wnt/MAPK轴控制鉴定外泌体miR-484在胰腺癌线粒体代谢重编程中的作用
(Identification of exosomal miR-484 role in reprogramming mitochondrial metabolism in pancreatic cancer through Wnt/MAPK axis control)
作者:Tianyu Lin* (Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China)
18. 肿瘤微环境的表征和与局部进展期直肠癌新辅助放化疗有益相关的空间预测性生物标志物的鉴定
(Characterization of the tumor microenvironment and identification of spatially predictive biomarkers associated with beneficial neoadjuvant chemoradiotherapy in locally advanced rectal cancer)
作者:Shifen Zhang, Na Li* (Department of Pathology, Nanfang Hospital/School of Basic Medical Sciences, Southern Medical University, China; Shenzhen Engineering Center for Translational Medicine of Precision Cancer Immunodiagnosis and Therapy, YuceBio Technology Co., Ltd, China)
19. 靶向IL-11系统治疗肺动脉高压
(Targeting IL-11 system as a treatment of pulmonary arterial hypertension)
作者:Javier Milara* (CIBER de enfermedades respiratorias, Health Institute Carlos III, Spain)

八、抗病毒研究 (2023年第219卷)

November 2023 - Volume 219 (2023年11月第219卷)

Research article(研究文章)
1. 增强脂质瑞德西韦单磷酸核苷前药3-F-4-MeO-Bn、3-CN和4-CN衍生物的体外广谱抗病毒效果
(Enhanced broad spectrum in vitro antiviral efficacy of 3-F-4-MeO-Bn, 3-CN, and 4-CN derivatives of lipid remdesivir nucleoside monophosphate prodrugs)
作者:Rachel E. McMillan, Aaron F. Carlin* (Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, School of Medicine, USA)
2. 打破陈规:克服对免疫检查点抑制剂的耐药性
(Breaking the mold: Overcoming resistance to immune checkpoint inhibitors)
作者:Menglu Zhao, Xi-He Zhao* (Department of Clinical Oncology, Shengjing Hospital of China Medical University, China)
3. 环孢素A诱导抗病毒基因表达,而不抑制亲环素A或B,有助于限制人冠状病毒229E在肺上皮细胞系中的感染
(Induction of antiviral gene expression by cyclosporine A, but not inhibition of cyclophilin A or B, contributes to its restriction of human coronavirus 229E infection in a lung epithelial cell line)
作者:John E. Mamatis, Che C. Colpitts* (Department of Biomedical and Molecular Sciences, Queen's University, Canada)
4. 盐酸白屈菜红碱通过靶向病毒NS4B蛋白抑制寨卡病毒感染
(Chelerythrine chloride inhibits Zika virus infection by targeting the viral NS4B protein)
作者:Marcus Wing Choy Loe,  Justin Jang Hann Chu* (Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore)
5. 新型hDHODH抑制剂MEDS433对呼吸道合胞病毒复制的抗病毒作用机制
(Mechanisms of antiviral activity of the new hDHODH inhibitor MEDS433 against respiratory syncytial virus replication)
作者:Anna Luganini, Giorgio Gribaudo* (Department of Life Sciences and Systems Biology, University of Torino, Italy)
6. 解旋酶引发酶抑制剂IM-250的间歇治疗能有效地控制复发性疱疹疾病并减少潜伏性HSV的再激活
(Intermittent therapy with helicase-primase inhibitor IM-250 efficiently controls recurrent herpes disease and reduces reactivation of latent HSV)
作者:David I. Bernstein, Gerald Kleymann* (Cincinnati Children's Hospital Medical Center (CCHMC), University of Cincinnati, USA; Innovative Molecules GmbH, Germany)
7. 由Nostoc edaphicum CCNP1411生产的cyanopeptolins抗SARS-CoV-2活性研究
(Anti-SARS-CoV-2 activity of cyanopeptolins produced by Nostoc edaphicum CCNP1411)
作者:Robert Konkel, Krzysztof Pyrc* (Department of Marine Biology and Biotechnology, Faculty of Oceanography and Geography, University of Gdańsk, Poland; Virogenetics Laboratory of Virology, Małopolska Centre of Biotechnology, Jagiellonian University, Poland)
8. 高度可逆性SARS-CoV-2型进入抑制剂1-(4-(芳基亚乙基羰基)苯基)-4-羧基-2-吡咯烷酮的合成、评价和机制
(Synthesis, evaluation, and mechanism of 1-(4-(arylethylenylcarbonyl)phenyl)-4-carboxy-2-pyrrolidinones as potent reversible SARS-CoV-2 entry inhibitors)
作者:Srinivasa Rao Palla, Chih-Jung Kuo* (Institute of Biological Chemistry, Academia Sinica, Taiwan, China; Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taiwan, China)
9. 替拉曲考通过靶向病毒RNA依赖性RNA聚合酶NS5抑制黄热病病毒复制
(Tiratricol inhibits yellow fever virus replication through targeting viral RNA-dependent RNA polymerase of NS5)
作者:Hao Ren, Jiaqi Wang, Hailin Tang, Zhongtian Qi*, Ping Zhao* (Department of Microbiology, Faculty of Naval Medicine, Shanghai Key Laboratory of Medical Biodefense, Naval Medical University, China)

九、英国药理学杂志 (2023年第180卷第21-22期)

(一) November 2023 - Volume 180 - Issue 21 (2023年11月第180卷第21期)

Review Article(综述文章)
(Small interfering RNA: Discovery, pharmacology and clinical development—An introductory review)
作者:Priyanga Ranasinghe* (Department of Pharmacology, Faculty of Medicine, University of Colombo, Sri Lanka)

Research Article(研究文章)
1. 虚拟药物筛选揭示心肌细胞肥大的相关依赖性抑制
(Virtual drug screen reveals context-dependent inhibition of cardiomyocyte hypertrophy)
作者:Taylor G. Eggertsen, Jeffrey J. Saucerman* (Department of Biomedical Engineering, University of Virginia, USA)
2. 药理抑制TRPV2可减弱原代巨噬细胞的吞噬作用和脂多糖诱导的迁移
(Pharmacological inhibition of TRPV2 attenuates phagocytosis and lipopolysaccharide-induced migration of primary macrophages)
作者:Rick Raudszus, Kerstin Hill* (Rudolf-Boehm-Institute of Pharmacology and Toxicology, Leipzig University, Germany)
3. 模式选择性拮抗剂对TRPV1的pH依赖性调节
(pH-dependent modulation of TRPV1 by modality-selective antagonists)
作者:Jan Daniluk, Thomas Voets* (Laboratory of Ion Channel Research (LICR), VIB-KU Leuven Centre for Brain & Disease Research, Belgium)
4. CDN1163是一种sarco/内质网Ca2+ ATP酶激活剂,可上调线粒体功能并保护胰岛β细胞免受脂毒性
(CDN1163, an activator of sarco/endoplasmic reticulum Ca2+ ATPase, up-regulates mitochondrial functions and protects against lipotoxicity in pancreatic β-cells)
作者:Ha Thu Nguyen, Kyu-Sang Park* (Department of Physiology, Yonsei University Wonju College of Medicine, Korea)
5. 雄性小鼠反复暴露于合成大麻素JWH-018后的认知功能障碍和神经可塑性受损
(Cognitive dysfunction and impaired neuroplasticity following repeated exposure to the synthetic cannabinoid JWH-018 in male mice)
作者:Sabrine Bilel, Matteo Marti* (Department of Translational Medicine, Section of Legal Medicine and LTTA Center, University of Ferrara, Italy)
6. 治疗大鼠慢性缺氧肺动脉高压的新药OP2113
(OP2113, a new drug for chronic hypoxia-induced pulmonary hypertension treatment in rat)
作者:Lukas Roubenne, Christelle Guibert* (Univ. Bordeaux, INSERM, France)
7. 周围神经损伤后跨性别和物种的保守转录编程预测神经病理性疼痛的治疗
(Conserved transcriptional programming across sex and species after peripheral nerve injury predicts treatments for neuropathic pain)
作者:Shahrzad Ghazisaeidi, Michael W. Salter* (Department of Physiology, University of Toronto, Canada)

(二) November 2023 - Volume 180 - Issue 22 (2023年11月第180卷第22期)

Translational Advances In Fibrosis As A Therapeutic Target - Editorial(纤维化作为治疗靶点的转化研究进展 - 社论)
1. 纤维化的治疗靶点:转化进展和当前挑战
(Therapeutic targets of fibrosis: Translational advances and current challenges)
作者:Miles J. De Blasio, Eliot H. Ohlstein* (Cardio-Metabolic Physiology, Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Australia; Department of Pharmacology & Physiology, Drexel University College of Medicine, USA)

Translational Advances In Fibrosis As A Therapeutic Target - Themed Issue Reviews(纤维化作为治疗靶点的转化研究进展 - 主题综述)
1. 靶向CD26/二肽基肽酶4 (DPP4)在器官纤维化中的作用
(Targeting cluster of differentiation 26 / dipeptidyl peptidase 4 (CD26/DPP4) in organ fibrosis)
作者:Birte Ohm* (Department of Thoracic Surgery, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Germany)
2. 器官纤维化的发病机制:聚焦坏死性凋亡
(The pathogenesis of organ fibrosis: Focus on necroptosis)
作者:Min Hao, Gang Cao* (School of Pharmacy, Zhejiang Chinese Medical University, China)
3. 慢性肝病:从发展到新型药物治疗:IUPHAR综述37
(Chronic liver diseases: From development to novel pharmacological therapies: IUPHAR Review 37)
作者:Maria Teresa Borrello* (Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, UK)

Translational Advances In Fibrosis As A Therapeutic Target - Themed Issue Reviews(纤维化作为治疗靶点的转化研究进展 - 主题文章)
1. 表达转录因子21的活化肾成纤维细胞的单细胞G蛋白偶联受体谱
(Single cell G-protein coupled receptor profiling of activated kidney fibroblasts expressing transcription factor 21)
作者:Harmandeep Kaur, Andrew Advani* (Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Canada)

Translational Advances In Fibrosis As A Therapeutic Target - Invited Review(纤维化作为治疗靶点的转化研究进展 - 特邀综述)
1. 心脏纤维化治疗的当前挑战:糖尿病心脏降糖治疗的性别特异性差异的最新见解:IUPHAR综述33
(Current challenges in the treatment of cardiac fibrosis: Recent insights into the sex-specific differences of glucose-lowering therapies on the diabetic heart: IUPHAR Review 33)
作者:Abhipree Sharma, Rebecca Ritchie* (Heart Failure Pharmacology, Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences (MIPS), Monash University, Australia)

十、临床药代动力学 (2023年第62卷第11期)

November 2023 -Volume 62 - Issue 11 (2023年11月第62卷第11期)

Review Article(综述文章)
1. 虚弱患者癌症相关血栓的抗凝治疗:患者虚弱对药物相互作用管理的影响
(Anti-coagulant Treatment of Cancer-Associated Thrombosis in Frail Patients: Impact of Frailties on the Management of Drug–Drug Interactions)
作者:Claire Grange* (Service de Médecine Interne-Médecine Vasculaire, Hospices Civils de Lyon, France)
2. 选择性S1P1受体调节剂Ponesimod治疗多发性硬化症的临床药代动力学
(Clinical Pharmacokinetics of Ponesimod, a Selective S1P1 Receptor Modulator, in the Treatment of Multiple Sclerosis)
作者:Terra M. Kruger* (Department of Clinical Pharmacology and Pharmacometrics, Janssen Research & Development, USA)
3. 为药效学和机器学习的世界搭建桥梁
(Bridging the Worlds of Pharmacometrics and Machine Learning)
作者:Kamilė Stankevičiūtė, Jean-Baptiste Woillard* (Department of Computer Science and Technology, University of Cambridge, UK; INSERM U1248 P&T, University of Limoges, France)

Original Research Article(原创研究文章)
1. 肥胖和哮喘儿童口服维生素D的药代动力学研究
(Pharmacokinetics of Oral Vitamin D in Children with Obesity and Asthma)
作者:Jason E. Lang* (Duke Children’s Hospital and Health Center, USA)
2. 恒格列净在糖尿病透析患者中的药代动力学研究
(Pharmacokinetics of Henagliflozin in Dialysis Patients with Diabetes)
作者:Li Ding, Shang Liu, Leyi Gu* (Department of Nephrology, Molecular Cell Lab for Kidney Disease, Shanghai Peritoneal Dialysis Research Center, Renji Hospital, Uremia Diagnosis and Treatment Center, Shanghai Jiao Tong University School of Medicine, China)
3. 伊立替康诱导的毒性:一项超越UGT1A1的药物遗传学研究
(Irinotecan-Induced Toxicity: A Pharmacogenetic Study Beyond UGT1A1)
作者:Mirjam de With, Sander Bins* (Department of Medical Oncology, Erasmus Medical Center Cancer Institute, The Netherlands)
4. 多元精确差异:PK/PD模型评价的新工具
(Multivariate Exact Discrepancy: A New Tool for PK/PD Model Evaluation)
作者:Sarah Baklouti, Didier Concordet* (Laboratoire de Pharmacocinétique et Toxicologie, Institut Fédératif de Biologie, CHU de Toulouse, France; INTHERES, Université de Toulouse, INRAE, ENVT, France)
5. 母亲吸食大麻导致的大麻二酚暴露:对母乳喂养婴儿的预测
(Cannabidiol Exposure Through Maternal Marijuana Use: Predictions in Breastfed Infants)
作者:Cindy H. T. Yeung, Andrea N. Edginton* (Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Canada; School of Pharmacy, University of Waterloo, Canada)
6. 艾司西酞普兰与舍曲林在儿科患者群体药代动力学分析
(Escitalopram and Sertraline Population Pharmacokinetic Analysis in Pediatric Patients)
作者:Ethan A. Poweleit, Laura B. Ramsey* (Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, USA; Division of Research in Patient Services, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, USA)
7. 使用两种不同浓度QTc建模方法评估Vericiguat的QTc效应
(Assessing QTc Effects of Vericiguat Using Two Different Concentration-QTc Modeling Approaches)
作者:Hauke Ruehs, Michaela Meyer* (Pharmacometrics, Bayer AG, Germany)