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国际TOP10药学期刊文章信息 (2023年7月)

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July 2023 - Volume 114 - Issue 1(2023年7月第114卷第1期)

1. 临床药理学和治疗学的发展趋势
(Trends in Clinical Pharmacology and Therapeutics)
作者:Iris K. Minichmayr, D. Max Smith (Medical University of Vienna, Austria; MedStar Health, USA)
White Paper(白皮书)
1. 使用未经治疗的HIV阳性者进行临床试验,为下一代艾滋病毒暴露前预防提供便利:一项源自预防HIV实验方案的共识
(Facilitating Next-Generation Pre-Exposure Prophylaxis Clinical Trials Using HIV Recent Infection Assays: A Consensus Statement from the Forum HIV Prevention Trial Design Project)
作者:Neil Parkin, Veronica Miller* (Data First Consulting, USA; Forum for Collaborative Research, USA)
2. 在药物评估的背景下朝着以问题为中心的监管决策方法迈进
(Moving Toward a Question-Centric Approach for Regulatory Decision Making in the Context of Drug Assessment)
作者:Flora T. Musuamba (University of Namur, Namur Research Institute for Life Sciences, Belgium)
CPIC Update(CPIC更新)
(Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants)
作者:Chad A. Bousman, Jeffrey R. Bishop* (Department of Medical Genetics, University of Calgary, Canada; Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, USA)

1. 通过药物公平视角推进CYP2D6遗传药理学
(Advancing CYP2D6 Pharmacogenetics through a Pharmacoequity Lens)
作者:Oyinlade Kehinde, Akinyemi Oni-Orisan* (Child and Adolescents Mental Health Service Center, Federal Neuro-Psychiatric Hospital, Nigeria; Department of Clinical Pharmacy, University of California San Francisco, USA)
2. 使用基于模型的药物开发范例优化西妥昔单抗和雷莫西尤单抗给药方案
(Safety Monitoring of COVID-19 Vaccines: Perspective from the European Medicines Agency)
作者:Lan Ni (Eli Lilly and Company, Indianapolis, USA)
Systematic Review(系统综述)
1. ABCB1基因变异与抗抑郁治疗结果:包括CAN-BIND-1研究结果的系统综述和Meta分析
(ABCB1 Gene Variants and Antidepressant Treatment Outcomes: A Systematic Review and Meta-Analysis Including Results from the CAN-BIND-1 Study)
作者:Leen Magarbeh, Daniel J. Müller* (Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada)
1. 肾移植受者接种SARS-CoV-2疫苗后,麦考酚酸暴露决定抗体的形成:一项巢式队列研究
(Mycophenolic Acid Exposure Determines Antibody Formation Following SARS-CoV-2 Vaccination in Kidney Transplant Recipients: A Nested Cohort Study)
作者:Soufian Meziyerh (Department of Medicine, Division of Nephrology, Leiden University Medical Center, The Netherlands)
2. 药物代谢酶基因多态性和联合用药对南非黑人乳腺癌患者他莫昔芬代谢的影响
(Effects of Genetic Polymorphisms of Drug Metabolizing Enzymes and co-Medications on Tamoxifen Metabolism in Black South African Women with Breast Cancer)
作者:Shingirai M. Chiwambutsa, Collen Masimirembwa* (Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, South Africa)
3. 用于评估肝脏切除、胆汁排泄和转运蛋白功能的新型人类肝脏移植模型
(Novel Explanted Human Liver Model to Assess Hepatic Extraction, Biliary Excretion and Transporter Function)
作者:Lianne J. Stevens, Ian P.J. Alwayn* (Department of Surgery, Leiden University Medical Center (LUMC), The Netherlands)
4. 在治疗领域中快速发展的欧洲有条件上市许可:2006-2020年抗癌药品的全面研究
(European Conditional Marketing Authorization in a Rapidly Evolving Treatment Landscape: A Comprehensive Study of Anticancer Medicinal Products in 2006–2020)
作者:Lourens T. Bloem (Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, The Netherlands)
5. 多态UGT2B17对双氯芬酸的肠道代谢与其群体间的药代动力学和安全性高度可变性相关
(Intestinal Metabolism of Diclofenac by Polymorphic UGT2B17 Correlates with its Highly Variable Pharmacokinetics and Safety across Populations)
作者:Deepak Ahire, Bhagwat Prasad* (Department of Pharmaceutical Sciences, Washington State University, USA)
6. 慢性丙型肝炎对不同阶段肝纤维化患者的膜转运蛋白P-gp和OATP1B1/BCRP活性影响
(Effect of Chronic Hepatitis C on the Activity of the Membrane Transporters P-gp and OATP1B1/BCRP on Patients With Different Stages of Hepatic Fibrosis)
作者:Leandro Francisco Pippa, Vera Lucia Lanchote* (Department of Clinical Analyses, Toxicology and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil)
7. 使用基于生理学的药代动力学的模型以确定CYP2B6基因型对儿童、母亲和母乳喂养婴儿依非韦伦暴露的影响
(Physiologically Based Pharmacokinetic Modeling to Determine the Impact of CYP2B6 Genotype on Efavirenz Exposure in Children, Mothers and Breastfeeding Infants)
作者:Xian Pan, Karen Rowland Yeo* (Certara UK Limited (Simcyp Division), UK)
8. 他克莫司和麦考酚酸暴露与活检证实的急性排斥反应相关:一项为长期目标范围提供证据的研究
(Tacrolimus and Mycophenolic Acid Exposure Are Associated with Biopsy-Proven Acute Rejection: A Study to Provide Evidence for Longer-Term Target Ranges)
作者:Soufian Meziyerh (Division of Nephrology, Department of Medicine, Leiden University Medical Center, The Netherlands)
9. 艾曲波帕在不同年龄组的安全性:真实世界药物警戒和随机临床试验分析
(Safety Profile of Eltrombopag in Different Age Groups: An Analysis of Real-World Pharmacovigilance and Randomized Clinical Trials)
作者:Han Qu1, Zhenghua Wu1*, Yuefen Lou2*, Guorong Fan1* (1. School of Pharmacy, Shanghai Jiao Tong University, China; 2. Department of Pharmacy, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, China)
10. 多发性骨髓瘤患者与单克隆抗体相关的肿瘤溶解综合征:基于FAERS数据库的药物警戒研究
(Tumor Lysis Syndrome Associated with Monoclonal Antibodies in Patients with Multiple Myeloma: A Pharmacovigilance Study Based on the FAERS Database)
作者:Shuang Xia, Hui Gong*, Miao Yan* (Department of Pharmacy, The Second Xiangya Hospital, Central South University, China)
11. 伊沙佐米维持治疗在不适合移植的多发性骨髓瘤患者中的剂量滴定:TOURMALINE-MM4研究的暴露-反应分析
(Dose Titration of Ixazomib Maintenance Therapy in Transplant-Ineligible Multiple Myeloma: Exposure–Response Analysis of the TOURMALINE-MM4 Study)
作者:Jaydeep K. Srimani, Neeraj Gupta* (Takeda Development Center Americas, Inc., USA)
12. 口服抗凝剂的浓度对亚洲心房颤动患者临床疗效的影响
(Impact of Direct Oral Anticoagulant Concentration on Clinical Outcomes in Asian Patients with Atrial Fibrillation)
作者:Shin-Yi Lin, Sung-Chun Tang* (Department of Pharmacy, National Taiwan University Hospital, China; Department of Neurology, Stroke Center, National Taiwan University Hospital, China)


July 2023 - Volume 75 - Issue 4(2023年7月第75卷第4期)

Reviews Articles(综述文章)
1. 尿失禁及相关疾病的现状和新兴药理学靶点及治疗
(Current and Emerging Pharmacological Targets and Treatments of Urinary Incontinence and Related Disorders)
作者:Martin C. Michel (Department of Pharmacology, University Medical Center, Johannes Gutenberg University, Germany)
2. 细胞衰老:从机制到当前的生物标志物和Senotherapies
(Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies)
作者:Vasco Lucas (Centre for Neuroscience and Cell Biology (CNC), Portugal)
3. 药理学中的自然语言处理综述
(Review of Natural Language Processing in Pharmacology)
作者:Dimitar Trajanov (Faculty of Computer Science and Engineering, Ss. Cyril and Methodius University in Skopje, Slovenia)
4. 纳米酶作为病毒诊断和治疗范例的研究进展
(Advances in Nanozymes as a Paradigm for Viral Diagnostics and Therapy)
作者:Garima Sharma (Department of Biomedical Science & Institute of Bioscience and Biotechnology, Kangwon National University, Korea)
5. 钾通道在帕金森病中的作用:其发病机制的潜在作用和用于治疗的创新分子靶点
(Potassium Channels in Parkinson’s Disease: Potential Roles in Its Pathogenesis and Innovative Molecular Targets for Treatment)
作者:Xiaoyi Chen (School of Environment and Science and Centre for Cancer Cell Biology and Drug Discovery, Australia)
6. 药物基因组学:推动个体化治疗
(Pharmacogenomics: Driving Personalized Medicine)
作者:Wolfgang Sadee (Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, USA)


July 2023 - Volume 198 (2023年7月第198卷)

Review article(综述文章)
1. 用于治疗慢性病的长效胃肠外给药系统
(Long-acting parenteral drug delivery systems for the treatment of chronic diseases)
作者:Anil B. Jindal (Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, India)
2. 长效PLGA微球:增强对产品理解的赋形剂和产品分析的研究进展
(Long-acting PLGA microspheres: Advances in excipient and product analysis toward improved product understanding)
作者:Bo Wan, Diane Burgess* (University of Connecticut, Department of Pharmaceutical Sciences, USA)
3. 玻璃体视网膜疾病药物眼内注射的现状与挑战
(Recent advances and future prospects: Current status and challenges of the intraocular injection of drugs for vitreoretinal diseases)
作者:Noriyasu Hashida (Department of Ophthalmology, Osaka University Graduate School of Medicine, Japan)
4. 眼部局部给药中的非水制剂—一种范式转变?
(Non-aqueous formulations in topical ocular drug delivery – A paradigm shift?)
作者:Priyanka Agarwal (Buchanan Ocular Therapeutics Unit, Department of Ophthalmology, New Zealand National Eye Centre, New Zealand)
5. 用于女性健康的3D打印植入式给药装置:制剂挑战和监管视角
(3D printed implantable drug delivery devices for women’s health: Formulation challenges and regulatory perspective)
作者:Karen Al-Litani, Pamela Robles Martinez*, Asma Buanz* (UCL School of Pharmacy, University College London, UK)
6. 吸入给药用于哮喘靶向治疗
(Inhaled drug delivery for the targeted treatment of asthma)
作者:Allison Boboltz1, Sahana Kumar2, Gregg A. Duncan1* (1. Fischell Department of Bioengineering, University of Maryland, USA; 2. Biological Sciences Graduate Program, University of Maryland, USA)
7. 先天性免疫的分子影像学和免疫疗法
(Molecular imaging of innate immunity and immunotherapy)
作者:Wenxi Xia, Neetu Singh, Shreya Goel*, Sixiang Shi* (Department of Molecular Pharmaceutics, University of Utah, USA)
8. 控制葡萄膜炎的眼微环境中免疫抑制分子和新型药物递送
(Ocular immunosuppressive microenvironment and novel drug delivery for control of uveitis)
作者:Sean Teabagy, Darren J. Lee* (Department of Ophthalmology and Visual Sciences, University of Massachusetts Chan Medical School, USA)

1. 微生物组、微环境及新型药物递送系统在创面愈合中的作用
(Role of microbiome, microenvironment and novel drug delivery system in the wound healing)
作者:Gaoxing Luo (Burns Surgery, Institute of Burn Research, Southwest Hospital, Third Military Medical University, China)
Review article(综述文章)
1. 宿主微生物群对真菌感染的影响:介入治疗的新可能性?
(Impact of the host microbiota on fungal infections: New possibilities for intervention?)
作者:Eve W.L. Chow, Li Mei Pang, Yue Wang* (A*STAR Infectious Diseases Laboratories (ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore)
2. 生物医学应用中基于细胞的中继递送策略
(Cell-based relay delivery strategy in biomedical applications)
作者:Yu Chen, Quanyin Hu* (Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, USA)
3. 新型抗真菌策略:药物组合和联合给药
(New antifungal strategies: Drug combination and co-delivery)
作者:Ping Zhu1, Yan Li2, Chengzhi Zhao3*, Chaoyang Xue4*, Guojian Liao1* (1. State Key Laboratory of Silkworm Genome Biology, College of Pharmaceutical Sciences, Southwest University, China; 2. Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, China; 3. Chongqing Health Center for Women and Children, China; 4. Public Health Research Institute and Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School, USA)
4. 长效疫苗递送系统
(Long-acting vaccine delivery systems)
作者:Pavan Walvekar, Yahya E. Choonara* (Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, South Africa)
5. 通过气液界面培养以模拟通过黏液纤毛上皮屏障的药物递送
(Air-Liquid interface cultures to model drug delivery through the mucociliary epithelial barrier)
作者:Rhianna E Lee, Boris Reidel, Scott H Randell* (Marsico Lung Institute and Cystic Fibrosis Research Center, USA)
6. 隐形和伪隐形纳米载体
(Stealth and pseudo-stealth nanocarriers)
作者:Panyue Wen1, Wendong Ke2, Junjie Li1*(1. Institute for Materials Chemistry and Engineering, Kyushu University, Japan; 2. Chemical Macromolecule Division, Asymchem Life Science (Tianjin) Co., Ltd., China)
7. 经角膜给药策略在眼科疾病治疗中的应用
(Trans-corneal drug delivery strategies in the treatment of ocular diseases)
作者:Liping Li1, Fan Jia2, Xinghuai Sun1*, Yuan Lei1*, Jian Ji2* (1. Shanghai Key Laboratory of Visual Impairment and Restoration, Key Laboratory of Myopia of Ministry of Health, Eye and ENT Hospital of Fudan University, China; 2. MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, China)
8. 开发长效药物递送系统的前体药物方法
(Prodrug approaches for the development of a long-acting drug delivery systems)
作者:Shin-Tian Chien, Kim A. Woodrow* (Department of Bioengineering, University of Washington, USA)


July 2023 - Volume 44 - Issue 7(2023年7月第44卷第7期)

1. 理解SLC22多特异性的序幕结束
(The end of the beginning in understanding SLC22 polyspecificity)
作者:Marleen Julia Meyer-Tönnies, Mladen Vassilev Tzvetkov* (Department of General Pharmacology, Institute of Pharmacology, Center of Drug Absorption and Transport (C_DAT), University Medicine Greifswald, Germany)


1. 推进化学致癌性预测模型:机遇与挑战
(Advancing chemical carcinogenicity prediction modeling: opportunities and challenges)
作者:Aayushi Mittal*, Gaurav Ahuja* (Department of Computational Biology, Indraprastha Institute of Information Technology-Delhi (IIIT-Delhi), India)
2. 人工智能驱动的抗自身免疫性疾病药物开发
(Artificial intelligence-driven drug development against autoimmune diseases)
作者:Philippe Moingeon (Research and Development, Servier Laboratories, France)
1. 治疗性多肽的研究进展
(Recent advances in the development of therapeutic peptides)
作者:John Fetse, Kun Cheng* (Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, USA)
2. 色氨酸代谢产物在犬尿氨酸途径中对T细胞的调节
(Modulation of T cells by tryptophan metabolites in the kynurenine pathway)
作者:Trevor W. Stone, Richard O. Williams* (The Kennedy Institute of Rheumatology, University of Oxford, UK)
3. 二甲双胍降糖作用的肠-肝平衡
(Striking a gut–liver balance for the antidiabetic effects of metformin)
作者:Emma Barroso, Manuel Vázquez-Carrera* (Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Spain)
4. 蛋白质-蛋白质相互作用:通过共价策略开发小分子抑制剂/稳定剂
(Protein-protein interactions: developing small-molecule inhibitors/stabilizers through covalent strategies)
作者:Bobby Lucero, Carlo Ballatore* (Department of Chemistry and Biochemistry, University of California, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, USA)


July 2023 - Volume 247 (2023年7月第247卷)

Review article(综述文章)
1. 二十二碳六烯酸及其衍生物对视网膜完整性的重要作用
(The essential role of docosahexaenoic acid and its derivatives for retinal integrity)
作者:Daniëlle Swinkels, Myriam Baes* (Laboratory of Cell Metabolism, Department of Pharmaceutical and Pharmacological Sciences, Belgium)
2. 致病辅助T细胞成为免疫介导的难治性疾病的新治疗靶点
(Pathogenic helper T cells as the novel therapeutic targets for immune-mediated intractable diseases)
作者:Atsushi Onodera, Kota Kokubo, Toshinori Nakayama*,  Kiyoshi Hirahara* (Department of Immunology, Graduate School of Medicine, Chiba University, Japan)
3. 细菌细胞外囊泡及其与免疫系统的相互作用
(Bacterial extracellular vesicles and their interplay with the immune system)
作者:Etienne Doré, Eric Boilard* (Centre de Recherche du Centre Hospitalier Universitaire de Québec - Université Laval, Canada)
4. 肺动脉高压中的肺血管纤维化——细胞外基质作为治疗靶点的作用
(Pulmonary vascular fibrosis in pulmonary hypertension – The role of the extracellular matrix as a therapeutic target)
作者:Katharina Jandl (Division of Pharmacology, Otto Loewi Research Center, Medical University Graz, Austria)
5. 靶向巨噬细胞线粒体功能:动脉粥样硬化性心血管疾病的新治疗策略?
(Targeting mitochondrial function in macrophages: A novel treatment strategy for atherosclerotic cardiovascular disease?)
作者:Pierre - Hadrien Becker (Université Paris-Saclay, France)
6. 酸中毒相关疼痛及其受体可作为慢性疼痛靶点
(Acidosis-related pain and its receptors as targets for chronic pain)
作者:Chih-Hsien Hung1, Yin Chin2, Wei-Hsin Sun2*, Chih-Cheng Chen3* (1. Department of Neurology, Kaohsiung Medical University Hospital, Taiwan, China; 2. Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taiwan, China; 3. Institute of Biomedical Sciences, Academia Sinica, Taiwan, China)
7. 催乳素与子宫内膜异位症疼痛
(Prolactin and pain of endometriosis)
作者:Grace J. Lee, Edita Navratilova* (Department of Pharmacology, College of Medicine, University of Arizona, USA)
8. 特异性促炎症消退介质在肺纤维化中有用吗?
(Is there a role for specialized pro-resolving mediators in pulmonary fibrosis?)
作者:Thomas H. Thatcher, Patricia J. Sime* (Division of Pulmonary Care and Critical Care Medicine, Virginia Commonwealth University, USA)
9. 甲基转移酶抑制剂将肿瘤内皮细胞作为靶向目标:作用机制和联合治疗的潜力
(Targeting tumor endothelial cells with methyltransferase inhibitors: Mechanisms of action and the potential of combination therapy)
作者:Shu Zhou1, Hailong Ou1, Xiaoxiao Hu1*, Erxi Wu2* (1. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Molecular Science and Biomedicine Laboratory and Aptamer Engineering Center of Hunan Province, Hunan University, China; 2. Department of Neurosurgery, Neuroscience Institute, Baylor Scott & White Health, USA)
10. 肥胖、癌症和对免疫检查点抑制剂的反应:肠道微生物群可能存在机制联系吗?
(Obesity, cancer, and response to immune checkpoint inhibitors: Could the gut microbiota be the mechanistic link?)
作者:Matthieu Delaye, Cindy Neuzillet* (Curie Institute, Department of medical oncology, Versailles Saint-Quentin University, France)
11. 标志性乙基在心血管预防中的作用:通过二十碳五烯酸消退素E1 - ChemR23轴缓解炎症
(Icosapent ethyl in cardiovascular prevention: Resolution of inflammation through the eicosapentaenoic acid - resolvin E1 - ChemR23 axis)
作者:Magnus Bäck (Department of Cardiology, Heart and Vascular Center, Karolinska University Hospital, Sweden)
12. 癌症中的整合素:新机制和治疗机会
(Integrins in cancer: Emerging mechanisms and therapeutic opportunities)
作者:Fangfang Liu1, Qiong Wu2, Zigang Dong1*, Kangdong Liu1* (1. Research Center of Basic Medicine, Academy of Medical Sciences, Zhengzhou University, China; 2. China-US (Henan) Hormel Cancer Institute, China)
13. 口腔疾病炎症的消退
(Resolution of inflammation in oral diseases)
作者:Eiba G. Eltay, Thomas Van Dyke* (Department of Applied Oral Sciences, The Forsyth Institute, USA)


(一)July 2023 - Volume 83 - Issue 10(2023年7月第83卷第10期)

Leading Article(社评)
1. 治疗双相抑郁的药理学新方法
(New Pharmacologic Approaches to the Treatment of Bipolar Depression)
作者:Kamyar Keramatian, Trisha Chakrabarty, Lakshmi N. Yatham* (Department of Psychiatry, University of British Columbia, Canada)
Review Article(综述文章)
1. 静脉注射美沙酮治疗围术期和慢性癌症疼痛:文献综述
(Intravenous Methadone for Perioperative and Chronic Cancer Pain: A Review of the Literature)
作者:Sebastiano Mercadante (Main Regional Center for Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Italy)
2. IL-23靶向治疗炎症性肠病:基本原理和迄今进展
(Targeting IL-23 for IBD: Rationale and Progress to Date)
作者:Sudheer K. Vuyyuru, Brian G. Feagan* (Department of Medicine, Division of Gastroenterology, Western University, Canada)
3. 急性移植物抗宿主病:新治疗方案的最新进展
(Acute Graft-versus-Host Disease: An Update on New Treatment Options)
作者:Dilan A. Patel, Mark A. Schroeder* (Section of BMT & Leukemia, Division of Oncology, Department of Medicine, Washington University, USA)
Systematic Review(系统综述)
1. 生物治疗对炎症性肠病患者疲劳的影响:系统综述和Meta分析
(The Effect of Biological Treatment on Fatigue in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis)
作者:Berit Mære Skjellerudsveen, Roald Omdal* (Department of Internal Medicine, Stavanger University Hospital, Norway)
Adis Drug Evaluation(Adis药物评价)
1. 芬氟拉明:德拉维特和雷诺-加斯特奥综合征的综述
(Fenfluramine: A Review in Dravet and Lennox-Gastaut Syndromes)
作者:James E. Frampton (Springer Nature, New Zealand)
AdisInsight Report(AdisInsight报告)
1. 格菲妥单抗:首次获批
(Glofitamab: First Approval)
作者:Matt Shirley (Springer Nature, New Zealand)
2. Leniolisib:首次批准
(Leniolisib: First Approval)
作者:Sean Duggan (Springer Nature, New Zealand)

(二)July 2023 - Volume 83 - Issue 11(2023年7月第83卷第11期)

Current Opinion(现行意见)
1. 在哮喘治疗中预期使用长效毒蕈碱拮抗剂是否合适?
(Might It Be Appropriate to Anticipate the Use of Long-Acting Muscarinic Antagonists in Asthma?)
作者:Mario Cazzola (Unit of Respiratory Medicine, Department of Experimental Medicine, University of Rome, Italy)
Review Article(综述文章)
1. 新型保护性β-内酰胺类抗生素的延长和持续输注:叙述性综述
(Extended and Continuous Infusion of Novel Protected β-Lactam Antibiotics: A Narrative Review)
作者:Francesco Venuti*, Mattia Trunfio (Unit of Infectious Diseases, Department of Medical Sciences, Amedeo di Savoia Hospital, University of Turin, Italy)
2. 聚焦二甲双胍:其在妊娠期及以后的作用和安全性
(Focus on Metformin: Its Role and Safety in Pregnancy and Beyond)
作者:Christine Newman (Centre for Diabetes, Endocrinology and Metabolism, Galway University Hospital, Ireland)
3. 神经性疼痛和脊髓损伤:管理、表型和生物标志物
(Neuropathic Pain and Spinal Cord Injury: Management, Phenotypes, and Biomarkers)
作者:Eva Widerström-Noga (The Miami Project to Cure Paralysis, University of Miami, USA)
Systematic Review(系统综述)
1. 非布地奈德疗法治疗显微镜下结肠炎的疗效:系统评价和Meta分析
(Effectiveness of Non-Budesonide Therapies in Management of Microscopic Colitis: A Systematic Review and Meta-analysis)
作者:Amalie Rehde, Ole Haagen Nielsen* (Department of Gastroenterology D112, The IBD Clinic, Herlev Hospital, University of Copenhagen, Denmark)
AdisInsight Report(AdisInsight报告)
1. Tofersen:首次获批
(Tofersen: First Approval)
作者:Hannah A. Blair (Springer Nature, New Zealand)
2. Mirikizumab:首次获批
(Mirikizumab: First Approval)
作者:Susan J. Keam (Springer Nature, New Zealand)
3. Concizumab:首次获批
(Concizumab: First Approval)
作者:Susan J. Keam (Springer Nature, New Zealand)


July 2023 - Volume 193 (2023年7月第193卷)

Review Articles(综述文章)
1. Ⅰ型糖尿病预测预防方面的经验和差距
(Lessons and gaps in the prediction and prevention of type 1 diabetes)
作者:Chiara Mameli (Department of Pediatrics, V. Buzzi Children's Hospital, Italy)
2. α9*和α7烟碱受体的小分子配体:考察和更新
(Small molecule ligands for α9 * and α7 nicotinic receptors: A survey and an update, respectively)
作者:Alessandro Giraudo, Cristiano Bolchi* (Department of Pharmaceutical Sciences, University of Milan, Italy)
3. 多酚的抗帕金森效应:一篇侧重于肠-脑轴调节的叙述性综述
(Antiparkinsonian effects of polyphenols: A narrative review with a focus on the modulation of the gut-brain axis)
作者:Wei Zhang, Rui Huang* (Department of Neurology, Shengjing Hospital of China Medical University, China)
4. 细胞外囊泡在衰老相关慢性肾脏病中的作用:恶魔还是天使
(Roles of extracellular vesicles in ageing-related chronic kidney disease: Demon or angel)
作者:Siqi Yin1, Zixuan Zhou1, Peiwen Fu2 , Chaoying Jin3, Min Xu1*, Hui Qian1* (1. Institute of Translational Medicine of Jiangsu University, Affiliated Hospital of Jiangsu University, China; 2. Key Laboratory of Laboratory Medicine of Jiangsu Province, Department of laboratory Medicine, School of Medicine, Jiangsu University, China; 3. Department of Plastic and Aesthetic Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, China)
5. 补充螺旋藻对血脂谱的影响:对随机对照试验数据进行GRADE评估的系统综述和剂量-反应Meta分析
(The effect of Spirulina supplementation on lipid profile: GRADE-assessed systematic review and dose-response meta-analysis of data from randomized controlled trials)
作者:Iman Rahnama1, Saeid Hadi1*, Amirhossein Sahebkar2* (1. Department of Health and Nutrition, Faculty of Medicine, AJA University of Medical Sciences, Iran; 2. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Iran)
6. 综述:心脏纤维化中的乙酰化机制和靶向治疗
(Review: Acetylation mechanisms and targeted therapies in cardiac fibrosis)
作者:Weikang Liu, Qiuhuan Yuan, Yuan Bian*, Feng Xu*,  Yuguo Chen* (Department of Emergency Medicine, Qilu Hospital of Shandong University, China)
Regular article(常规文章)
1. 通过单细胞转录组学揭示11-酮-β-乳香酸和Z-Guggulsterone治疗缺血性卒中的新型协同机制
(Novel synergistic mechanism of 11-keto-β-boswellic acid and Z-Guggulsterone on ischemic stroke revealed by single-cell transcriptomics)
作者:Tianlong Liu1, Min Bai1, Minna Liu2, Jingwen Wang1*, Aidong Wen1*, Yi Ding1* (1. Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, China; 2. Department of Nephrology, The 940th Hospital Joint Logistics Support Forces of PLA, China)
2. 肠道真菌组和代谢性疾病:已知、未知和未来
(Gut mycobiome and metabolic diseases: The known, the unknown, and the future)
作者:Lijie Wang, Tingting Kuang*, Gang Fan* (State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy and School of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, China)
3. 描绘草本有机化合物对肠道细菌的调节作用
(Mapping the regulatory effects of herbal organic compounds on gut bacteria)
作者:Yulong Zhang, Ting Chen, Xiaoqing Hao, Weihua Huang*, Wei Zhang* (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, China)
4. 诱导多模式机制下调乳腺癌中雌激素、孕激素、雄激素和催乳素受体的创新缩氧硫脲类药物
(Innovative thiosemicarbazones that induce multi-modal mechanisms to down-regulate estrogen-, progesterone-, androgen- and prolactin-receptors in breast cancer)
作者:Faten Shehadeh-Tout1, Des R. Richardson2*, Zaklina Kovacevic1* (1. School of Medical Sciences, University of Sydney, Australia; 2. Centre for Cancer Cell Biology and Drug Discovery, Griffith Institute for Drug Discovery, Griffith University, Nathan, Australia)
5. 生长激素缺乏儿童中长效生长激素替代疗法与每日生长激素治疗的疗效、安全性、生活质量、依从性和成本效益比较:一项系统综述和Meta分析
(Efficacy, safety, quality of life, adherence and cost-effectiveness of long-acting growth hormone replacement therapy compared to daily growth hormone in children with growth hormone deficiency: A systematic review and meta-analysis)
作者:Chiara Mameli (Department of Pediatrics, Buzzi Children's Hospital, Italy)
6. 抑制ALOX5可防止多巴胺能神经元发生铁死亡
(ALOX5 inhibition protects against dopaminergic neurons undergoing ferroptosis)
作者:Kun Li, Lei Liang*, Yi-Fang Li*, Wen-Jun Duan*, Rong-Rong He* (Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE)/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, China)
7. DNMT3a介导的TCF21/hnRNPA1甲基化通过调节NF-κB信号通路加重肝纤维化
(DNMT3a-mediated methylation of TCF21/hnRNPA1 aggravates hepatic fibrosis by regulating the NF-κB signaling pathway)
作者:Liangyun Li, Shaoxi Diao, Cheng Huang*, Jun Li* (Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, China)
8. 老龄化世界中高胆固醇血症和缺血性心脏病的负担
(The burden of hypercholesterolemia and ischemic heart disease in an ageing world)
作者:Angela Pirillo, Giuseppe Danilo Norata* (Center for the Study of Atherosclerosis, E. Bassini Hospital, Italy; Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy)
9. 使用药物血浆浓度和管理/医疗数据库对安全信号进行药理学证实的新方法:一项使用丹麦注册机构对FDA关于拉莫三嗪的警告进行案例研究
(A novel approach for pharmacological substantiation of safety signals using plasma concentrations of medication and administrative/healthcare databases: A case study using Danish registries for an FDA warning on lamotrigine)
作者:Wenyi Wang1, Vera Battini2, Hiie Soeorg3*, Maurizio Sessa4* (1. Department of Human Genetics, Leiden University Medical Center, Netherlands; 2. Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, Italy; 3. Department of Microbiology, Institute of Biomedicine and Translational Medicine, Faculty of Medicine, University of Tartu, Estonia; 4. Department of Drug Design and Pharmacology, University of Copenhagen, Denmark)
10. 酚类代谢产物作为炎症和肿瘤的治疗药物:解释其疗效的分子途径
(Phenolic metabolites as therapeutic in inflammation and neoplasms: Molecular pathways explaining their efficacy)
作者:Wenshi Liu, Bo Liu* (Department of Translantation/Hepatobiliary, The First Hospital of China Medical University, China; Department of Cardiac Surgery, The First Hospital of China Medical University, China)
11. 荷叶碱的构效关系、生物活性、分子机制及在炎症相关疾病中的临床应用
(Structure-activity relationship, bioactivities, molecular mechanisms, and clinical application of nuciferine on inflammation-related diseases)
作者:Tong Zhao1, Jianjun Deng2*, Haixia Yang1* (1. College of Food Science and Nutritional Engineering, China Agricultural University, China; 2. State Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, China)
12. 靶向KRT16-vimentin轴在肺癌转移中的作用
(Targeting the KRT16-vimentin axis for metastasis in lung cancer)
作者:Wen Wang1, Lifei Zhu2, Jiao Zhou1, Xiaoli Liu1, Xiaofeng Pei1*,  Hongyu Zhang1* (1. Department of Oncology, The fifth Affiliated Hospital of Sun Yat-sen University, China; 2. Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, China)
13. 在肠道微生物群和内源性代谢产物参与的低氧微环境下,小檗碱抑制乳腺癌增殖和转移
(Berberine inhibits breast carcinoma proliferation and metastasis under hypoxic microenvironment involving gut microbiota and endogenous metabolites)
作者:Yanfang Sun1*, QianQian Zhou1, Gautam Sethi2* (1. College of Life Sciences and Medicine, Zhejiang Sci-Tech University, China; 2. Department of Pharmacology, National University of Singapore, Singapore)


July 2023 - Volume 215(2023年7月第215卷)

Research article(研究文章)
1. 小鼠和树鼩模型中Cas9 mRNA和引导RNA的联合递送可编辑乙型肝炎病毒的游离和整合DNA
(Co-delivery of Cas9 mRNA and guide RNAs edits hepatitis B virus episomal and integration DNA in mouse and tree shrew models)
作者:Junzhu Yi, Jiangwei Lin* (State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, China; Group of Nonhuman Primates Reproductive and Stem Cell, Kunming Institute of Zoology, China)
2. 移植受者中巨细胞病毒抗病毒药物耐药性的患病率
(Prevalence of cytomegalovirus antiviral drug resistance in transplant recipients)
作者:Steven B. Kleiboeker (Eurofins Viracor Clinical Diagnostics, USA)
3. 氧甾醇合成类似物作为2型单纯疱疹病毒复制晚期新抑制剂的鉴定
(Identification of oxysterol synthetic analogs as a novel class of late-stage inhibitors of herpes simplex virus 2 replication)
作者:Andrea Civra1, Matteo Costantino1, Maura Marinozzi2*, David Lembo1* (1. Department of Clinical and Biological Sciences, University of Turin, Italy; 2. Department of Pharmaceutical Sciences, University of Perugia, Italy)
4. 茴香霉素通过促进eEF1A1的溶酶体降解抑制柯萨奇B组病毒复制
(Anisomycin inhibits Coxsackievirus B replication by promoting the lysosomal degradation of eEF1A1)
作者:Enze Shao1, Shuoxuan Zhao1, Yanyan Dong1, Wenran Zhao1*, Zhaohua Zhong2* (1. Department of Cell Biology, Harbin Medical University, China; 2. Department of Microbiology, Harbin Medical University, China)
5. 宿主因子DUSP5通过调节细胞骨架重排抑制登革病毒感染
(Host factor DUSP5 potently inhibits dengue virus infection by modulating cytoskeleton rearrangement)
作者:Minqi Liang, Shu An* (School of Public Health, Sun Yat-sen University, China; Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, China)
6. 人巨细胞病毒CRISPR-Cas12a快速诊断法的开发
(Development of a CRISPR-Cas12a rapid diagnostic for human cytomegalovirus)
作者:Chandler H. Monk, Kevin J. Zwezdaryk* (Bioinnovation Program, Tulane University School of Medicine, USA; Department of Microbiology and Immunology, Tulane University School of Medicine, USA)
7. 青蒿琥酯通过抑制PDE4导致细胞内cAMP积累,减少ERK/MAPK信号通路,阻断甲型流感病毒vRNP核输出
(Artesunate inhibits PDE4 leading to intracellular cAMP accumulation, reduced ERK/MAPK signaling, and blockade of influenza A virus vRNP nuclear export)
作者:Xia Yang1, Feixiang Long1, Weisan Chen2*, Jianxin Chen1* (1. Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, China; 2. Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Australia)
8. 长链非编码RNA#61通过其长臂环发挥广泛的抗流感病毒作用
(Long noncoding RNA #61 exerts a broad anti-influenza a virus effect by its long arm rings)
作者:Jiao Hu, Lei Zhang, Xinxin Zheng, Liu, Xiufan* (Animal Infectious Disease Laboratory, School of Veterinary Medicine, Yangzhou University, China)
Short communication(简报)
1. Sotrovimab对仓鼠模型中BQ.1.1和XBB.1奥密克戎亚系的活性
(Activity of Sotrovimab against BQ.1.1 and XBB.1 Omicron sublineages in a hamster model)
作者:Jean-Sélim Driouich, Antoine Nougairède* (Unité des Virus Émergents, UVE: Aix Marseille Univ, France)
Research article(研究文章)
1. SARS-CoV-2可诱导心肌细胞的凋亡和炎症,但ACE抑制剂卡托普利可改善这一情况
(SARS-CoV-2 induces cardiomyocyte apoptosis and inflammation but can be ameliorated by ACE inhibitor Captopril)
作者:Xiaohan Huang, Jincun Zhao* (State Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, China)
2. 甲型流感病毒NS1蛋白207位点的突变改变了其调节RIG-I样受体介导的抗病毒应答的功能
(Mutations at site 207 of influenza a virus NS1 protein switch its function in regulating RIG-I-like receptors mediated antiviral responses)
作者:Xingbo Wang, Lulu Lin, Jiyong Zhou* (MOA Key Laboratory of Animal Virology, Zhejiang University Center for Veterinary Sciences, China)
3. 重组猪干扰素混合物延缓非洲猪瘟的发病并减轻其严重程度
(Recombinant porcine interferon cocktail delays the onset and lessens the severity of African swine fever)
作者:Pengtao Jiao1, Shuchao Wang2, Wenhui Fan1, Lei Sun1* (1. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, China; 2. Institute of Military Veterinary Medicine, Academy of Military Medical Science, China)


(一)July 2023 - Volume 180 - Issue 13(2023年7月第180卷第13期)

Invited Review(特邀综述)
1. 神经退行性疾病的靶向治疗新方法
(Novel therapeutic approaches to target neurodegeneration)
作者:Alerie G. De La Fuente, Elena Marcello* (Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Spain; Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy)
Research Articles(研究文章)
1. 具有强G蛋白偶联但抑制蛋白募集和受体脱敏受损的偏向性GLP-2激动剂可增强小鼠肠道生长
(Biased GLP-2 agonist with strong G protein-coupling but impaired arrestin recruitment and receptor desensitization enhances intestinal growth in mice)
作者:Maria Buur Nordskov Gabe, Mette Marie Rosenkilde* (Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark)
2. 胆管结扎增加了大鼠大脑皮层的多巴胺水平的部分原因是酪氨酸羟化酶的诱导
(Bile duct ligation increased dopamine levels in the cerebral cortex of rats partly due to induction of tyrosine hydroxylase)
作者:Weimin Kong, Xiaodong Liu*, Li Liu* (Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, China)
3. P2X7受体有助于新生小鼠缺氧后癫痫发作和炎症驱动的持久脑过度兴奋
(The P2X7 receptor contributes to seizures and inflammation-driven long-lasting brain hyperexcitability following hypoxia in neonatal mice)
作者:Jonathon Smith1, Eva M. Jimenez-Mateos2*, Tobias Engel1* (1. Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Ireland; 2. Discipline of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, The University of Dublin, Ireland)
4. 外周感觉神经元上催产素受体的上调可用于化疗诱导的神经性疼痛的镇痛
(Up-regulation of oxytocin receptors on peripheral sensory neurons mediates analgesia in chemotherapy-induced neuropathic pain)
作者:Lixuan Li, Zilong Wang* (Guangdong Medical University, Zhanjiang, China; Department of Medical Neuroscience, Key University Laboratory of Metabolism and Health of Guangdong, SUSTech Center for Pain Medicine, School of Medicine, Southern University of Science and Technology, China)
5. 异恶唑9 (ISX9)是一种靶向Axin的小分子,可激活Wnt/β-catenin信号通路并促进毛发再生
(Isoxazole 9 (ISX9), a small molecule targeting Axin, activates Wnt/β-catenin signalling and promotes hair regrowth)
作者:Sapna Sayed, Qi Sun*, Desheng Lu* (Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, International Cancer Center, Department of Pharmacology, Shenzhen University Medical School, China)
6. 产前暴露于大麻素受体激动剂WIN 55,212-2引起的大鼠性别和年龄特异性呼吸改变
(Sex- and age-specific respiratory alterations induced by prenatal exposure to the cannabinoid receptor agonist WIN 55,212-2 in rats)
作者:Luis Gustavo A. Patrone*, Luciane H. Gargaglioni* (Department of Animal Morphology and Physiology, São Paulo State University-UNESP/FCAV, Brazil)

(二)July 2023 - Volume 180 - Issue 14 (2023年7月第180卷第14期)

Invited Review(特邀综述)
1. 硫化氢和表观遗传学:这种气体递质对心血管影响的新见解
(Hydrogen sulfide and epigenetics: Novel insights into the cardiovascular effects of this gasotransmitter)
作者:Jacopo Spezzini, Alma Martelli*, Vincenzo Calderone* (Department of Pharmacy, University of Pisa, Italy)
Research Article(研究文章)
1. 硫酸乙酰肝素模拟物Muparfostat因其与脂蛋白脂酶的结合亲和力而加重肥胖小鼠的脂肪性肝炎
(The heparan sulfate mimetic Muparfostat aggravates steatohepatitis in obese mice due to its binding affinity to lipoprotein lipase)
作者:Jia Zhang, Peng Sun* (Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, Nanjing Medical University, China)
2. 在长期戒除慢性可卡因期间,杏仁核-苍白球腹侧通路有助于腹侧被盖区的低多巴胺能状态
(The amygdala–ventral pallidum pathway contributes to a hypodopaminergic state in the ventral tegmental area during protracted abstinence from chronic cocaine)
作者:Adélie Salin, Pauline Belujon* (Université de Poitiers, INSERM, U-1084, Laboratoire des Neurosciences Expérimentales et Cliniques, France)
3. 猪腰椎鞘内和鞘外区头孢呋辛浓度的评价——实验研究
(Evaluation of cefuroxime concentration in the intrathecal and extrathecal compartments of the lumbar spine—an experimental study in pigs)
作者:Alexander Emil Kaspersen (Department of Clinical Medicine, Faculty of Health, Aarhus University, Denmark)
4. 血管紧张素缺乏型FVB/N小鼠血压正常
(Angiotensin deficient FVB/N mice are normotensive)
作者:André Felipe Rodrigues, Michael Bader* (Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Germany)
5. 通过增强血管内皮细胞线粒体呼吸和糖酵解,Piezo1通道激活并刺激ATP产生
(Piezo1 channel activation stimulates ATP production through enhancing mitochondrial respiration and glycolysis in vascular endothelial cells)
作者:Man Jiang1, Zhi-Jie Sun2*, De-Li Dong1* (1. Department of Pharmacology (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, China; 2. Department of Pharmacology, China Pharmaceutical University, China)
6. 一种富含甘氨酸-丝氨酸-丙氨酸重复序列的肽可改善阿尔茨海默型神经退行性变
(A peptide rich in glycine–serine–alanine repeats ameliorates Alzheimer-type neurodegeneration)
作者:Si-Yuan Yao, Wen-Bing Yao* (Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, China)


July 2023 -Volume 62 - Issue 7(2023年7月第62卷第7期)

Review Article(综述文章)
1. 体外膜肺氧合的危重患者抗真菌药物剂量
(Antifungal Dosing in Critically Ill Patients on Extracorporeal Membrane Oxygenation)
作者:Haifa Lyster, Jason A. Roberts* (Royal Brompton and Harefield Hospitals, Part of Guy’s and St Thomas’ NHS Foundation Trust, UK; Faculty of Medicine, University of Queensland Centre for Clinical Research, The University of Queensland, Australia)
2. 根据FDA动物规则批准的抗感染药物的临床和转化药理学考虑因素
(Clinical and Translational Pharmacology Considerations for Anti-infectives Approved Under the FDA Animal Rule)
作者:Zaid H. Temrikar, Bernd Meibohm* (Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, USA)
Systematic Review(系统综述)
1. 造血细胞移植中静脉注射白消安的群体药代动力学模型:系统综述和比较模拟
(Population Pharmacokinetic Model of Intravenous Busulfan in Hematopoietic Cell Transplantation: Systematic Review and Comparative Simulations)
作者:Takuto Takahashi (Division of Stem Cell Transplantation, Department of Pediatrics, Boston Children’s Hospital/Dana-Farber Cancer Institute, USA)
Original Research Article(原创研究文章)
1. 应用群体药代动力学方法预测化疗药物在哺乳妇女母乳中的分布
(Predicting Chemotherapy Distribution into Breast Milk for Breastfeeding Women Using a Population Pharmacokinetic Approach)
作者:David Damoiseaux (Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute, The Netherlands)
2. 健康个体中咪达唑仑的绝对生物利用度和清除率的个体内变异性
(Intraindividual Variability in Absolute Bioavailability and Clearance of Midazolam in Healthy Individuals)
作者:Kine Eide Kvitne (Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Norway)
3. 恩扎卢胺可减少前列腺癌患者的羟考酮暴露
(Enzalutamide Reduces Oxycodone Exposure in Men with Prostate Cancer)
作者:S. E. H. Detert Oude Weme, L. M. G. Hulskotte* (Department of Clinical Pharmacy, Deventer Teaching Hospital, The Netherlands)
4. 泊沙康唑在免疫受损儿童中的群体中的药代动力学及对侵袭性真菌病达标情况的评估
(Population Pharmacokinetics of Posaconazole in Immune-Compromised Children and Assessment of Target Attainment in Invasive Fungal Disease)
作者:Sean McCann, Daniel Gonzalez* (Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, USA)
5. 戊巴比妥治疗儿童癫痫持续状态和严重颅脑损伤儿童的群体药代动力学模型
(A Population Pharmacokinetic Model of Pentobarbital for Children with Status Epilepticus and Severe Traumatic Brain Injury)
作者:Naomi Ketharanathan*, Anastasia Lili (Department of Neonatal and Paediatric Intensive Care, Division of Paediatric Intensive Care, Erasmus MC-Sophia Children’s Hospital, The Netherlands; Rotterdam Clinical Pharmacometrics Group, Erasmus MC, The Netherlands)
6. 两种不同工艺生产的静脉注射用阿替普酶在健康男性志愿者中的生物等效性:一项两阶段、适应性设计研究的结果
(Bioequivalence of Intravenous Alteplase from Two Different Manufacturing Processes in Healthy Male Volunteers: Results from a Two-Stage, Adaptive-Design Study)
作者:Stephan Glund (Boehringer Ingelheim Pharma GmbH & Co. KG, Germany)
7. 使用HIV暴露前预防的巴西变性妇女中雌二醇和螺内酯的血浆药代动力学:潜在相互作用分析
(Estradiol and Spironolactone Plasma Pharmacokinetics Among Brazilian Transgender Women Using HIV Pre-Exposure Prophylaxis: Analysis of Potential Interactions)
作者:Vitória Berg Cattani (Evandro Chagas National Institute of Infectious Diseases INI Fiocruz, Brazil)