一、临床药理学与治疗学（2023年第114卷第2期）

August 2023 - Volume 114 - Issue 2（2023年8月第114卷第2期）
https://ascpt.onlinelibrary.wiley.com/toc/15326535/2023/114/2

Editorial（社论）
1. 外部控制臂：我们尚未进入巡航控制阶段
(External Control Arms: We're Not on Cruise Control Yet)
作者：Shirley K. Seo (Division of Cardiometabolic and Endocrine Pharmacology, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, FDA, USA)
Perspective（视角）
1. 采用临床药物基因组学MT-RNR1筛选氨基糖苷诱导的耳毒性和测试后咨询难题识
(Clinical Pharmacogenomic MT-RNR1 Screening for Aminoglycoside-Induced Ototoxicity and the Post-Test Counseling Conundrum)
作者：Robert Rigobello¹, Stuart A. Scott²*, Neal Cody¹* (1. GeneDx, Gaithersburg, USA; 2. Department of Pathology, Stanford University, USA)
White Paper（白皮书）
1. 药物开发中疾病进展建模的机遇与挑战–以IQ为视角
(Opportunities and Challenges of Disease Progression Modeling in Drug Development – An IQ Perspective)
作者：Kosalaram Goteti*, Jin Y. Jin* (Quantitative Pharmacology, EMD Serono Research and Development Institute, Inc., USA; Clinical Pharmacology, Genentech, Inc., USA)
Tutorial（教程）
1.医务人员心血管药物遗传学入门教程
(An Introductory Tutorial on Cardiovascular Pharmacogenetics for Healthcare Providers)
作者：Akinyemi Oni-Orisan (Department of Clinical Pharmacy, University of California San Francisco, USA)
Reviews（综述）
1. 肿瘤药物早期临床开发中有关患者的探索性食物效应评价
(Exploratory Food Effect Assessment in Patients in Early Clinical Development of Oncology Drugs)
作者：Yan Ji (Novartis Pharmaceuticals Corporation, USA)
2. 开发真实世界数据衍生外部控制的监管和HTA考虑因素
(Regulatory and HTA Considerations for Development of Real-World Data Derived External Controls)
作者：Lesley H. Curtis, Julien Heidt* (Duke Department of Population Health Sciences and Duke Clinical Research Institute, USA; IQVIA, Regulatory Science and Strategy, USA)
3. 欧盟伴随诊断新监管框架背景下生物标志物驱动的发展
(Biomarker-Driven Developments in the Context of the New Regulatory Framework for Companion Diagnostics in the European Union)
作者：Ciska Verbaanderd, Ana Trullás Jimeno* (PhaRA Consulting, Belgium; European Medicines Agency, The Netherlands)
Systematic Review（系统综述）
1. 有效利用RWD进行外部控制：监管和HTA决策的系统文献综述
(Effectively Leveraging RWD for External Controls: A Systematic Literature Review of Regulatory and HTA Decisions)
作者：Oriol Sola-Morales, Julien Heidt* (Fundació Health Innovation Technology Transfer and International, University of Catalonia, Spain; IQVIA, Regulatory Science and Strategy, USA)
Research（研究）
1. 基于基因数据库对疑似DPYD变异携带者接受氟嘧啶治疗的患者进行验证性DPYD检测
(Confirmatory DPYD Testing in Patients Receiving Fluoropyrimidines Who are Suspected DPYD Variant Carriers Based on a Genetic Data Repository)
作者：Amy L. Pasternak, Daniel L. Hertz* (Department of Clinical Pharmacy, University of Michigan College of Pharmacy, USA)
2. 成人心房颤动患者达比加群给药方案：真实世界患者的压力测试肾功能范围
(Dabigatran Dosing Proposal for Adults With Atrial Fibrillation: Stress-Testing Renal Function Range in Real World Patients)
作者：J. Robert Powell (Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, USA)
3. BAFF和ICOSL的双特异性抑制剂Rozibafusp Alfa的药代动力学和药代动力学/药效学特性：I期临床试验分析
(Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Properties of Rozibafusp Alfa, a Bispecific Inhibitor of BAFF and ICOSL: Analyses of Phase I Clinical Trials)
作者：Lubna Abuqayyas (Clinical Pharmacology, Modeling, and Simulation, Amgen Inc., USA)
4. 甲氧苄啶对硫胺素吸收的影响：转运蛋白介导的药物-营养相互作用
(The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction)
作者：Bianca Vora, Kathleen M. Giacomini* (Department of Bioengineering and Therapeutic Sciences, University of California, USA)
5. 抗高血压药物分类的全基因组关联研究揭示了耐药高血压的复杂发病机制
(Genome-wide Association Studies Categorized by Class of Antihypertensive Drugs Reveal Complex Pathogenesis of Hypertension with Drug Resistance)
作者：Keiko Yamazaki*, Yasuo Takahashi* (Division of Genomic Epidemiology and Clinical Trials, Clinical Trials Research Center, Nihon University School of Medicine, Japan)
6. 我们所有研究项目中常用抗生素引起的药物性肝损伤
(Drug-Induced Liver Injury with Commonly Used Antibiotics in the All of Us Research Program)
作者：Shaopeng Gu (Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, USA)
7. 基于反应的帕纳替尼给药剂量：剂量范围内基于模型的OPTIC研究分析
(Response-Based Dosing for Ponatinib: Model-Based Analyses of the Dose-Ranging OPTIC Study)
作者：Michael J. Hanley (Takeda Development Center Americas, Inc., USA)
8. 2C-B与裸盖菇素对主观体验、情绪和认知的急性影响评估
(Assessment of the Acute Effects of 2C-B vs. Psilocybin on Subjective Experience, Mood, and Cognition)
作者：Pablo Mallaroni*, Johannes G. Ramaekers* (Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands)
9. 氟氯西林是健康成人和人原代肝细胞三维球体CYP3A4的弱诱导因子
(Flucloxacillin Is a Weak Inducer of CYP3A4 in Healthy Adults and 3D Spheroid of Primary Human Hepatocytes)
作者：Ditte B. Iversen, Tore B. Stage* (Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Denmark)
10. 通过了解(−)-∆9-四氢大麻酚(THC)在灌注人胎盘中经胎盘转移的机制和程度，以预测胎儿体内THC暴露
(Understanding the Mechanism and Extent of Transplacental Transfer of (−)-∆9-Tetrahydrocannabinol (THC) in the Perfused Human Placenta to Predict In Vivo Fetal THC Exposure)
作者：Aditya R. Kumar, Jashvant D. Unadkat* (Department of Pharmaceutics, University of Washington, USA)
11. 通过一项儿童失神癫痫的随机对照临床试验开发的乙琥胺模型精准给药指导
(Model-Informed Precision Dosing Guidance of Ethosuximide Developed from a Randomized Controlled Clinical Trial of Childhood Absence Epilepsy)
作者：Kana Mizuno, Tracy A. Glauser* (Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, USA; Department of Pediatrics, University of Cincinnati, USA)
12. 基于生理的佛手柑素和6,7-二羟基佛手柑素的药代动力学模型描述CYP3A4介导的葡萄柚药物相互作用
(Physiologically Based Pharmacokinetic Modeling of Bergamottin and 6,7-Dihydroxybergamottin to Describe CYP3A4 Mediated Grapefruit-Drug Interactions)
作者：Laura Maria Fuhr, Thorsten Lehr* (Clinical Pharmacy, Saarland University, Germany)

二、药理学评论

（本刊为双月刊，每两月更新一次，详见10月更新）

三、先进药物输送评论（2023年第199卷）

August 2023 - Volume 199 （2023年7月第199卷)
https://www.sciencedirect.com/journal/advanced-drug-delivery-reviews/vol/199/suppl/C

Editorial（述评）
1. 专题前言：用于诊疗领域的前沿应用的功能性无机纳米材料
(Preface in special theme: Functional inorganic nanomaterials for cutting-edge theranostic applications)
作者：Bengang Xing, Xiaoyuan (Shawn) Chen (School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore; Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore)
Review article（综述文章）
1. 眼科治疗用外泌体的研究进展
(Advances in development of exosomes for ophthalmic therapeutics)
作者：Ying Tian, Tao Zhang, Yong Tao* (Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, China)
2. 脂质类长效注射剂的最新研究进展
(Recent advances in lipid-based long-acting injectable depot formulations)
作者：Reena Sharma, Sanyog Jain* (Department of Pharmaceutics, Centre for Pharmaceutical Nanotechnology, National Institute of Pharmaceutical Education & Research (NIPER), India)
3. 克服生物可降解给药系统中蛋白质和肽类不稳定性的策略
(Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems)
作者：Miusi Shi, Kevin J. McHugh* (Department of Ophthalmology, Osaka University Graduate School of Medicine, Japan)
4. 肿瘤学中的靶向微生物组、药物代谢和给药
(Targeting microbiome, drug metabolism, and drug delivery in oncology)
作者：Ai Sumiyoshi¹, Hiroyuki Fujii², Yusuke Okuma²* (1. Department of Pharmacy, National Cancer Center Hospital, Japan; 2. Department of Thoracic Oncology, National Cancer Center Hospital, Japan)
5. 基于化学技术的核酸药物开发
(Development of nucleic acid medicines based on chemical technology)
作者：Yusuke Kawamoto*, Yoshinobu Takakura* (Department of Biopharmaceutics and Drug Metabolism, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan)
6. 气溶胶肺部免疫工程
(Aerosol pulmonary immune engineering)
作者：Emma R. Sudduth, Catherine A. Fromen* (Department of Chemical and Biomolecular Engineering, University of Delaware, USA)
7. 从体外到体内：长效治疗IVIVC开发的综合指南
(From in vitro to in vivo: A comprehensive guide to IVIVC development for long-acting therapeutics)
作者：Giorgia Pastorin (Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore)
8. 研究核酸纳米结构治疗药物的体内给药问题
(Addressing the in vivo delivery of nucleic-acid nanostructure therapeutics)
作者：Shana Alexander, Leo Y.T. Chou* (Institute of Biomedical Engineering, University of Toronto, Canada)
9. 冲出大门：靶向动态紧密连接以改善给药新方法
(Storming the gate: New approaches for targeting the dynamic tight junction for improved drug delivery)
作者：Isabela Ramirez-Velez, Brian Belardi* (McKetta Department of Chemical Engineering, The University of Texas at Austin, USA)
10. 大分子鞘内给药：临床现状和新兴技术
(Intrathecal delivery of Macromolecules: Clinical status and emerging technologies)
作者：Rana Ajeeb, John R. Clegg* (Stephenson School of Biomedical Engineering, The University of Oklahoma, USA)
11. 念珠菌病：从皮肤到全身，潜在靶点和治疗策略的新视角
(Candidiasis: From cutaneous to systemic, new perspectives of potential targets and therapeutic strategies)
作者：Hui Lu¹, Ting Hong², Malcolm Whiteway³*, Shiqun Zhang¹* (1. Department of Pharmacology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine, China; 2. Department of Anesthesiology, Huadong Hospital Affiliated to Fudan University, China; 3. Department of Biology, Concordia University, Canada)
12. 适应与遗忘：通过纳米技术可实现牙科植入治疗的未来
(Fit and forget: The future of dental implant therapy via nanotechnology)
作者：Elizabeth Magill, Juan Domínguez-Robles*, Eneko Larrañeta* (School of Pharmacy, Queen’s University Belfast, UK)
13. 类内分泌器官治疗应用研究进展
(Recent advances in endocrine organoids for therapeutic application)
作者：Suwan Jeon¹, Young-sun Lee², Seh Ri Oh², Kyoung-Ha So²*, Nathaniel S. Hwang¹* (1. Interdisciplinary Program for Biochemical Engineering and Biotechnology, Seoul National University, Korea; 2. School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Korea)
14. 脂质纳米颗粒作为药物载体在人类视网膜疾病治疗中的最新进展与展望
(Recent advances and prospects for lipid-based nanoparticles as drug carriers in the treatment of human retinal diseases)
作者：Shaoxue Zeng, Ling Zhu* (Macula Research Group, Save Sight Institute, Faculty of Medicine and Health, The University of Sydney, Australia)
15. 临床应用中支持采用体外转录mRNA (IVT mRNA)的研究进展
(Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics)
作者：Diana D. Kang, Yizhou Dong* (Division of Pharmaceutics & Pharmacology, College of Pharmacy, The Ohio State University, USA)
16. 抗真菌治疗：新靶点驱动的新型给药策略
(Antifungal therapy: Novel drug delivery strategies driven by new targets)
作者：Shuang Wu, Tongbao Liu*, Chong Li* (State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, China)
17. 重新激发人们对多功能药物制霉菌素的兴趣：提高其作为有效安全抗真菌药物潜力的多种策略
(Reviving the interest in the versatile drug nystatin: A multitude of strategies to increase its potential as an effective and safe antifungal agent)
作者：Filipa Sousa*, Paulo Costa* (UCIBIO, REQUIMTE, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Portugal)
18. 阿尔茨海默病中siRNA药物通过血脑屏障给药
(siRNA drug delivery across the blood–brain barrier in Alzheimer's disease)
作者：Muhammad Imran Sajid, Rakesh Kumar Tiwari* (Department of Biomedical and Pharmaceutical Sciences, Harry and Diane Rinker Health Science Campus, Chapman University School of Pharmacy, USA)
19. mRNA在癌症免疫治疗中的研究进展：从修饰到递送
(Advances in mRNA therapeutics for cancer immunotherapy: From modification to delivery)
作者：Geonhee Han¹, Hong Yeol Yoon²*, Soo Hyeon Lee³* (1. KU-KIST Graduate School of Converging Science and Technology, Korea University, Korea; 2. Medicinal Materials Research Center, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Korea; 3. Molecular Surgery Laboratory, Byers Eye Institute, Department of Ophthalmology, Stanford University, USA)
20. 用于提高RNA治疗药物稳定性和安全性的复合结构设计
(Polyplex designs for improving the stability and safety of RNA therapeutics)
作者：Satoshi Uchida*, Kanjiro Miyata* (Department of Advanced Nanomedical Engineering, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Japan; Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, Japan)
21. 迈向人工智能驱动的细胞外囊泡精准给药
(Towards artificial intelligence-enabled extracellular vesicle precision drug delivery)
作者：Zachary F. Greenberg, Mei He* (Department of Pharmaceutics, College of Pharmacy, University of Florida, USA)
22. 亚细胞可视化：细胞器特异性靶向给药和发现
(Subcellular visualization: Organelle-specific targeted drug delivery and discovery)
作者：Xintian Shao, Qixin Chen* (School of Life Sciences, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, China; School of Pharmaceutical Sciences & Institute of Materia Medica, National Key Laboratory of Advanced Drug Delivery System, Medical Science and Technology Innovation Center, Key Laboratory for Biotechnology Drugs of National Health Commission, Shandong First Medical University & Shandong Academy of Medical Sciences, China)
23. 在亚细胞水平上追踪药物动力学的先进成像技术
(Advanced imaging techniques for tracking drug dynamics at the subcellular level)
作者：Chengying Zhang¹, Zhiqi Tian¹, Rui Chen², Jiajie Diao¹* (1. Department of Cancer Biology, University of Cincinnati College of Medicine, USA; 2. Department of Chemistry, University of Cincinnati, USA)
24. RNA干扰的靶向给药方法对于获得潜在的HIV/AIDS功能性治疗是必要的
(Targeted delivery methods for RNA interference are necessary to obtain a potential functional cure for HIV/AIDS)
作者：Ethan Cisneros, Nicholas A. Peppas* (McKetta Department of Chemical Engineering, University of Texas at Austin, USA)
25. mRNA：一个有前景的癌症免疫治疗平台
(mRNA: A promising platform for cancer immunotherapy)
作者：Byoungjae Kong¹, Jung Soo Suk¹*, Yoosoo Yang²* (1. Center for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University School of Medicine, USA; 2. Biomedical Research Division, Korea Institute of Science and Technology (KIST), Korea)
26. 生物材料辅助巨噬细胞治疗的再生医学
(Biomaterial-assisted macrophage cell therapy for regenerative medicine)
作者：Samuel Sung, Kara L. Spiller* (School of Biomedical Engineering, Science, and Health Systems, Drexel University, USA)

四、药理学发展趋势（2023年第44卷第8期）

August 2023 - Volume 44 - Issue 8（2023年8月第44卷第8期)
https://www.cell.com/trends/pharmacological-sciences/issue?pii=S0165-6147(22)X0009-6

Spotlight（聚焦）
1. 甘氨酸：一种寻找已久的新型GPR158配体
(Glycine: a long-sought novel ligand for GPR158)
作者：Mette Marie Rosenkilde*, Jesper Mosolff Mathiesen* (Department of Biomedical Sciences, University of Copenhagen, Denmark; Department of Drug Design and Pharmacology, University of Copenhagen, Denmark)
2. GPCRs的第三个细胞内环：大小很重要
(The third intracellular loop of GPCRs: size matters)
作者：Jürgen Wess (Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA)
Opinion（意见）
1. 使用靶向皮质-纹状体传导治疗大麻素使用障碍
(Targeting corticostriatal transmission for the treatment of cannabinoid use disorder)
作者：Sergi Ferré (Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, USA)
2. 在免疫治疗时代克服蛋白酶体抑制剂耐药性
(Overcoming proteasome inhibitor resistance in the immunotherapy era)
作者：Bonell Patiño-Escobar, Arun P. Wiita* (Department of Laboratory Medicine, University of California, USA)
Reviews（综述）
1. 靶向半乳糖凝集素-3在炎症和纤维化疾病中的作用
(Targeting galectin-3 in inflammatory and fibrotic diseases)
作者：Selena Bouffette, Frédéric De Ceuninck* (Servier, Neurology and Immuno-inflammation Therapeutic Area, Servier R&D Center, France)
2. 代谢组学引导的RiPP天然产物基因组挖掘
(Metabolome-guided genome mining of RiPP natural products)
作者：Mitja M. Zdouc*, Justin J.J. van der Hooft*, Marnix H. Medema* (Bioinformatics Group, Wageningen University & Research, the Netherlands)
3. 肿瘤微环境中免疫细胞的铁死亡
(Ferroptosis of immune cells in the tumor microenvironment)
作者：Rina Kim¹, Devon Taylor², Dmitry I. Gabrilovich²* (1. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, USA; 2. AstraZeneca, R&D Oncology, Gaithersburg, USA)
Drug of the Month（本月最佳药物）
1. Lenacapavir (Sunlenca®)用于治疗HIV-1
(Lenacapavir (Sunlenca®) for the treatment of HIV-1)
作者：Pratish C. Patel¹, Heather K. Beasley², Celestine N. Wanjalla¹* (1. Department of Pharmaceutical Services, Vanderbilt University Medical Center, USA; 2. Department of Molecular Physiology and Biophysics, Vanderbilt University, USA; 3. Department of Medicine, Division of Infectious Disease, Vanderbilt University Medical Center, USA)

五、药理学与治疗学（2023年第248卷）

August 2023 - Volume 248 （2023年8月第248卷)
https://www.sciencedirect.com/journal/pharmacology-and-therapeutics/vol/248/suppl/C

Review article（综述文章）
1. 测量大脑二十二碳六烯酸周转率作为代谢消耗的标志
(Measuring brain docosahexaenoic acid turnover as a marker of metabolic consumption)
作者：Brinley J. Klievik, Aidan D. Tyrrell, Richard P. Bazinet* (Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Canada)
2. 饮食中的类二十烷酸对癌症炎症的调节
(Regulation of inflammation in cancer by dietary eicosanoids)
作者：Haixia Yang¹*, Dipak Panigrahy²*, Jianjun Deng³* (1. College of Food Science and Nutritional Engineering, China Agricultural University, China; 2. Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, USA; 3. Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, China)
3. 改变葡萄糖醛酸化药物暴露的药物-药物之间相互作用：范围、UDP-葡萄糖醛酸基转移酶(UGT)酶的选择性、机制（抑制和诱导）和临床意义
(Drug-drug interactions that alter the exposure of glucuronidated drugs: Scope, UDP-glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and induction), and clinical significance)
作者：John O. Miners (Discipline of Clinical Pharmacology and Flinders Centre for Innovation in Cancer, Flinders University College of Medicine and Public Health, Flinders University, Australia)
4. 萜烯类：调节炎症性肠病的抗炎信号
(Terpenes: Modulating anti-inflammatory signaling in inflammatory bowel disease)
作者：Rocío Rivera Rodríguez, Jeremy James Johnson* (University of Illinois Chicago, College of Pharmacy, Department of Pharmaceutical Sciences, USA)
5. 外阴疾病的炎症、脂质和疼痛
(Inflammation, lipids, and pain in vulvar disease)
作者：Megan L. Falsetta (University of Rochester, OB/GYN Research Division, USA)
6. 胆汁酸代谢和信号传导：膳食多酚的新药理学靶点
(Bile acid metabolism and signaling: Emerging pharmacological targets of dietary polyphenols)
作者：Kevin M. Tveter, Diana E. Roopchand* (Rutgers, The State University of New Jersey, Department of Food Science, Institute for Food Nutrition and Health [Center for Microbiome, Nutrition and Health & Rutgers Center for Lipid Research], USA)
7. 调节性脂邻二醇可抵消环氧脂肪酸的生物活性，并可作为疾病进展的生物标志物和机理
(Regulatory lipid vicinal diols counteract the biological activity of epoxy fatty acids and can act as biomarkers and mechanisms for disease progression)
作者：Cindy McReynolds (EicOsis, Davis, USA)
8. 新型精神活性物质对新生儿的潜在毒性
(Potential neonatal toxicity of new psychoactive substances)
作者：Ryoichi Fujiwara*, Kousei Ito* (Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, USA; Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan)
9. 非编码RNA回路在黑色素瘤发病、可塑性和治疗反应中的作用
(Noncoding RNA circuitry in melanoma onset, plasticity, and therapeutic response)
作者：Katerina Grafanaki, Kerrie L. Marie* (Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, USA; Division of Molecular and Cellular Function, Faculty of Biology, Medicine and Health, University of Manchester, UK)
10. 伊马替尼在胃肠道间质瘤（GISTs）中产生耐药性背后的多方面因素：来自瑞普替尼的教训
(The multifaceted landscape behind imatinib resistance in gastrointestinal stromal tumors (GISTs): A lesson from ripretinib)
作者：Aldo Di Vito, Gloria Ravegnini, Sabrina Angelini* (Department of Pharmacy and Biotechnology, University of Bologna, Italy)
11. 通过调节神经免疫相互作用的慢性疼痛免疫疗法
(Immunotherapies in chronic pain through modulation of neuroimmune interactions)
作者：Junli Zhao, Ru-Rong Ji* (Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, USA)
12. 准备出击：血栓素A₂蛇形受体信号传导的急性事件
(Preparing to strike: Acute events in signaling by the serpentine receptor for thromboxane A₂)
作者：Anthony W. Ashton (Division of Cardiovascular Medicine, Lankenau Institute for Medical Research, USA)
13. 驱动眼部恶性肿瘤的信号通路及其生物活性植物化学物质的靶向作用
(Signaling pathways driving ocular malignancies and their targeting by bioactive phytochemicals)
作者：Courtney R. Croley¹, Joshua Pumarol², Anupam Bishayee³* (1. Healthcare Corporation of America, Department of Ophthalmology, Morsani College of Medicine, University of South Florida, USA; 2. Ross University School of Medicine, USA; 3. College of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, USA)
14. 肾脏中的维生素A和类视黄醇信号传导
(Vitamin A and retinoid signaling in the kidneys)
作者：Krysta M. DiKun, Lorraine J. Gudas* (Department of Pharmacology, Weill Cornell Medical College of Cornell University, USA)
15. 核受体的磷酸化：新颖性和治疗意义
(Phosphorylation of nuclear receptors: Novelty and therapeutic implications)
作者：Sawako Shindo¹, Masahiko Negishi²*, Ryota Shizu³* (1. Department of Environmental Toxicology, Meiji Pharmaceutical University, Japan; 2.Reproductive and Developmental Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, USA; 3. Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Japan)
16. 原卟啉IX诱导的光毒性：机制和治疗
(Protoporphyrin IX-induced phototoxicity: Mechanisms and therapeutics)
作者：Zahir Hussain, Qian Qi, Xiaochao Ma* (Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, USA)

六、药物（2023年第83卷第12期）

August 2023 - Volume 83 - Issue 12（2023年8月第83卷第122期)
https://link.springer.com/journal/40265/volumes-and-issues/83-12

Current Opinion（现行意见）
1. 妊娠患者癌症相关疼痛的药物治疗
(Pharmacologic Management of Cancer-Related Pain in Pregnant Patients)
作者：Isabelle Zerfas, Michael A. Smith* (Department of Pharmacy Services, University of Michigan Health, USA)
Leading Article（社评）
1. 外分泌胰腺糖尿病：对药理学管理的启示
(Diabetes of the Exocrine Pancreas: Implications for Pharmacological Management)
作者：Mark O. Goodarzi, Maxim S. Petrov* (Division of Endocrinology, Diabetes, and Metabolism, Cedars-Sinai Medical Center, USA; School of Medicine, University of Auckland, New Zealand))
Review Article（综述文章）
1. 晚期肝癌个体化一线治疗的新机遇
(New Opportunities to Individualize Frontline Therapy in Advanced Stages of Hepatocellular Carcinoma)
作者：John D. Gordan (Division of Hematology/Oncology, Helen Diller Family Comprehensive Cancer Center, USA)
Original Research Article（原创研究文章）
1. 奥玛珠单抗治疗严重哮喘：对口服皮质类固醇暴露和重塑的影响。一项随机开放标签平行研究
(Omalizumab in Severe Asthma: Effect on Oral Corticosteroid Exposure and Remodeling. A Randomized Open-Label Parallel Study)
作者：Christian Domingo*, Rosa M. Mirapeix (Pulmonary Service, Corporació Sanitària Parc Taulí, Spain; Department of Morphological Sciences, Medical School, Universitat Autònoma de Barcelona (UAB), Spain)
AdisInsight Report（AdisInsight报告）
1. Efbemalenograstim Alfa：首次获批
(Efbemalenograstim Alfa: First Approval)
作者：Hannah A. Blair (Springer Nature, New Zealand)
2. Beremagene Geperpavec：首次批准
 (Beremagene Geperpavec: First Approval)
作者：Sohita Dhillon (Springer Nature, New Zealand)
3.Fezolinetant：首次批准
 (Fezolinetant: First Approval)
作者：Arnold Lee (Springer Nature, New Zealand)

七、药理学研究（2023年第194卷）

August 2023 - Volume 194 （2023年8月第194卷)
https://www.sciencedirect.com/journal/pharmacological-research/vol/194/suppl/C

Review Articles（综述文章）
1. 化学线粒体自噬调节剂：药物开发策略和新的调节机制
(Chemical mitophagy modulators: Drug development strategies and novel regulatory mechanisms)
作者：Yu Dong, Xu-Xu Zhuang, Jia-Hong Lu* (State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, China)
2. 速效抗抑郁药的分子机制：开发抗抑郁药的新视角
(Molecular mechanisms of rapid-acting antidepressants: New perspectives for developing antidepressants)
作者：Tao Chen, Hongping Shen* (Key Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy of Southwest Medical University, China; Clinical trial center, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, China)
3. 星形胶质细胞衍生的细胞外囊泡在应激相关情绪障碍中的作用。免疫系统会变成星形细胞吗?
(Astrocyte-derived extracellular vesicles in stress-associated mood disorders. Does the immune system get astrocytic?)
作者：Alejandro Luarte*, Úrsula Wyneken* (Faculty of Medicine, Universidad de los Andes, Chile)
4. 缺氧在细胞衰老中的作用
(Role of hypoxia in cellular senescence)
作者：Haoyu Gao¹, Qinghua Wu¹*, Kamil Kuca²*, Vojtech Adam³* (1. College of Life Science, Yangtze University, China; 2. Department of Chemistry, Faculty of Science, University of Hradec Králové, Czech Republic; 3. Department of Chemistry and Biochemistry, Mendel University in Brno, Czech Republic)
5. 没食子酸甲酯：药理活性综述
(Methyl gallate: Review of pharmacological activity)
作者：Huaguo Liang, Yongli Zhang* (School of Basic Medical Sciences, Guangdong Pharmaceutical University, China)
6. 美国以外的监管机构批准的小分子蛋白激酶抑制剂
(Small molecule protein kinase inhibitors approved by regulatory agencies outside of the United States)
作者：Robert Roskoski Jr. (Blue Ridge Institute for Medical Research, USA)
7. 神经嵴细胞和胎儿酒精谱系障碍：预防的机制和潜在靶点
(Neural crest cells and fetal alcohol spectrum disorders: Mechanisms and potential targets for prevention)
作者：Shao-yu Chen*, Maharajan Kannan* (Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, USA)
8. 扩展细菌-器官理论：通过肠杆菌易位理解非传染性疾病
(Expanding germ-organ theory: Understanding non-communicable diseases through enterobacterial translocation)
作者：Seenivasan Boopathi¹, Jesu Arockiaraj²*, Ai-Qun Jia¹* (1. Hainan General Hospital, Hainan affiliated hospital of Hainan Medical University, China; 2. Toxicology and Pharmacology Laboratory, Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, India)
9. 基于MicroRNA的微生物群-肠-脑轴炎症性疾病的治疗方法
(MicroRNA-based therapeutics for inflammatory disorders of the microbiota-gut-brain axis)
作者：Neha Datta¹, Christos Polytarchou²*, Tanya M. Monaghan³* (1. School of Medicine, University of Nottingham, UK; 2. Department of Biosciences, John van Geest Cancer Research Centre, School of Science & Technology, Nottingham Trent University, UK; 3. NIHR Nottingham Biomedical Research Centre, University of Nottingham, UK)
10. 烟碱乙酰胆碱受体异构体的小分子选择性配体研究进展
(Advances in small molecule selective ligands for heteromeric nicotinic acetylcholine receptors)
作者：Carlo Matera, Marco De Amici* (Department of Pharmaceutical Sciences, Medicinal Chemistry Section “Pietro Pratesi”, University of Milan, Italy)
11. 抗癌药物组合的计算机学习模型：分析、预测和验证
(Machine learning model for anti-cancer drug combinations: Analysis, prediction, and validation)
作者：Jing-Bo Zhou, Dongyang Tang, Chu-Xia Deng* (Cancer Center, Faculty of Health Sciences, University of Macau, China)
12. 核因子-kappaB轴在前列腺癌症中的恶性功能：非编码RNA的分子相互作用和调控
(Malignant function of nuclear factor-kappaB axis in prostate cancer: Molecular interactions and regulation by non-coding RNAs)
作者：Reyadh R. Al-Rashidi¹, Noushin Nabavi²*, Yuzhuo Wang²*, Lin Wang³* (1. Department of Dentistry, Kut University College, Iraq; 2. Department of Urologic Sciences and Vancouver Prostate Centre, University of British Columbia, Canada; 3. Department of Geriatrics, Xijing Hospital, The Air Force Military Medical University, China)
13. 靶向赖氨酸甲基转移酶NSD3在肿瘤治疗中的应用前景
(Prospect of targeting lysine methyltransferase NSD3 for tumor therapy)
作者：Dan Li, Chung-Nga Ko* (State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, China; C-MER Dennis Lam and Partners Eye Center, Hong Kong International Eye Care Group, China)
14. 敢于梦想：将脂蛋白（a）作为一种因果和风险增强的因素
(Daring to dream: Targeting lipoprotein(a) as a causal and risk-enhancing factor)
作者：Marlys L. Koschinsky, Florian Kronenberg* (Robarts Research Institute, Schulich School of Medicine & Dentistry, The University of Western Ontario, Canada; Institute of Genetic Epidemiology, Medical University of Innsbruck, Austria)
15. 家族性高胆固醇血症的管理和实施的最新进展
(Recent advances in the management and implementation of care for familial hypercholesterolaemia)
作者：Nick S.R. Lan (Departments of Cardiology and Internal Medicine, Royal Perth Hospital, Australia)
16. Lynx1和内源性哺乳动物神经毒素样蛋白家族及其在调节nAChR功能中的作用
(Lynx1 and the family of endogenous mammalian neurotoxin-like proteins and their roles in modulating nAChR function)
作者：Talulla B. Palumbo, Julie.M. Miwa* (Department of Biological Sciences, Lehigh University, USA)
17. 尼古丁影响血糖稳态和糖尿病发展的中枢和外周作用
(Central and peripheral actions of nicotine that influence blood glucose homeostasis and the development of diabetes)
作者：Zuxin Chen¹, Xin-an Liu²*, Paul J. Kenny³* (1. Shenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, China; 2. Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, China; 3. Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, USA)
18. 针对肠道微生物群调控的食品和药物设计：当前的实验前景和未来的创新
(Food and drug design for gut microbiota-directed regulation: Current experimental landscape and future innovation)
作者：Xiaoxiang Gao, Qixiao Zhai* (State Key Laboratory of Food Science and Resources, Jiangnan University, Jiangnan University, China)
Research article（研究文章）
1. 一项随机对照试验表明，Chios mastiha精油在代谢异常的成人中具有降压、降血脂和抗肥胖作用
(Chios mastiha essential oil exhibits antihypertensive, hypolipidemic and anti-obesity effects in metabolically unhealthy adults - a randomized controlled trial)
作者：Aristea Gioxari¹, Charalampia Amerikanou², Adriana C. Kaliora²* (1. Department of Nutritional Science and Dietetics, School of Health Science, University of the Peloponnese, Greece; 2. Department of Nutrition and Dietetics, School of Health Science and Education, Greece)
2. AGRN通过激活Notch信号通路促进肺腺癌进展并可作为治疗靶点
(AGRN promotes lung adenocarcinoma progression by activating Notch signaling pathway and acts as a therapeutic target)
作者：Huan Zhang, Jiaqi Liang, Tao Lu, Zhengcong Chen*, Cheng Zhan* (Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, China)
3. 抑制CXXC5功能通过恢复Wnt/β-catenin信号通路拯救阿尔茨海默病表型
(Inhibition of CXXC5 function rescues Alzheimer’s disease phenotypes by restoring Wnt/β-catenin signaling pathway)
作者：Minguen Yoon¹, YoungSoo Kim²*, Kang-Yell Choi¹* (1. Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Korea; 2. Department of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Korea)
4. 胰腺癌症自噬的生物信息学分析、临床前和临床概念：串扰的复杂性和简单性
(A bioinformatics analysis, pre-clinical and clinical conception of autophagy in pancreatic cancer: Complexity and simplicity in crosstalk)
作者：Milad Ashrafizadeh¹, Gautam Sethi²*, Xianbin Zhang¹* (1. Department of General Surgery and Institute of Precision Diagnosis and Treatment of Digestive System Tumors, Carson International Cancer Center, Shenzhen University General Hospital, Shenzhen University, China; 2. Department of Pharmacology and NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore)
5. METTL3通过增强LncRNA GAS5甲基化促进线粒体分裂并诱导心脏纤维化
(METTL3 boosts mitochondrial fission and induces cardiac fibrosis by enhancing LncRNA GAS5 methylation)
作者：Bin Tu, Rui Li* (Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Anhui Medical University, China; Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, China)
6. 硫化氢调节CSE^-/-小鼠海绵体微循环中可溶性鸟苷酸环化酶的氧化还原状态
(Hydrogen sulfide regulates the redox state of soluble guanylate cyclase in CSE^-/- mice corpus cavernosum microcirculation)
作者：Miguel A. Olivencia, Roberta d'Emmanuele di Villa Bianca* (Department of Pharmacology and Toxicology, School of Medicine, Universidad Complutense de Madrid, Spain; Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Italy)
7. 小细胞肺癌免疫谱的多维特征揭示了具有不同预后和治疗脆弱性的临床相关免疫亚型
(Multi-dimensional characterization of immunological profiles in small cell lung cancer uncovers clinically relevant immune subtypes with distinct prognoses and therapeutic vulnerabilities)
作者：Lin Yang, Puyuan Xing* (Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China; Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China)
8. 靶向HBP1/TIMP3轴作为抗癌症的新策略
(Targeting of HBP1/TIMP3 axis as a novel strategy against breast cancer)
作者：Yue Zhou, Xiaowei Zhang* (Department of Biochemistry and Biophysics, School of Basic Medical Sciences, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, China)
9. 麦卢卡蜂蜜激活芳香烃受体：对皮肤炎症的影响
(Manuka honey activates the aryl hydrocarbon receptor: Implications for skin inflammation)
作者：Abdullah A. Alangari*, Paola Di Meglio* (Department of Pediatrics, College of Medicine, King Saud University, Saudi Arabia; St. John’s Institute of Dermatology, School of Basic and Medical Biosciences, King’s College London, UK)
10. Rho激酶抑制剂改善甲基苯丙胺诱导的精神分裂症雄性小鼠模型的认知障碍
(Rho kinase inhibitors ameliorate cognitive impairment in a male mouse model of methamphetamine-induced schizophrenia)
作者：Jingzhu Liao, Kiyofumi Yamada* (Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan)
11. 一种新的HIF2A突变导致血脂异常并促进肝脏脂质积聚
(A novel HIF2A mutation causes dyslipidemia and promotes hepatic lipid accumulation)
作者：Feiqiong Gao, Jiong Yu* (State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, China)
12. 在非小细胞肺癌中，CERS4预测阳性抗pd -1反应，并通过rhob介导的CD8⁺Tim3⁺耗尽T细胞抑制促进免疫调节
(CERS4 predicts positive anti-PD-1 response and promotes immunomodulation through Rhob-mediated suppression of CD8⁺Tim3⁺ exhausted T cells in non-small cell lung cancer)
作者：Jian Wang, Liang Liu* (Dr. Neher’s Biophysics Laboratory for Innovative Drug Discovery/State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, China; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China)
13. cinaciguat通过靶向PTL/NPC1L1缓解肠道菌群失调和代谢紊乱治疗混合型高脂血症的应用新潜力
(Novel application potential of cinaciguat in the treatment of mixed hyperlipidemia through targeting PTL/NPC1L1 and alleviating intestinal microbiota dysbiosis and metabolic disorders)
作者：Ang Jia, Pengwei Chen* (The First Affiliated Hospital of Jinzhou Medical University, China; Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, China)
14. 儿童炎症性肠病风险的多态性或抗TNF药物抗原性可作为反应的生物标志物
(Polymorphisms indicating risk of inflammatory bowel disease or antigenicity to anti-TNF drugs as biomarkers of response in children)
作者：Paula Zapata-Cobo, Luis A. López-Fernández* (Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, Spain)
15. 以一种可靠、快速、灵敏地创新策略研究微生物蛋白修饰：基于UV-C照射SARS-CoV-2尖突蛋白的治疗导向概念验证
(An innovative strategy to investigate microbial protein modifications in a reliable fast and sensitive way: A therapy oriented proof of concept based on UV-C irradiation of SARS-CoV-2 spike protein)
作者：Sergio Strizzi¹, Letizia Bernardo², PierLuigi Mauri²* (1. Department of Biomedical and Clinical Sciences, University of Milan, Italy; 2. Institute for Biomedical Technologies, National Research Council (ITB-CNR), Italy)
16. 琥珀酸信号减弱高脂饮食诱导的代谢紊乱和肠道屏障功能障碍
(Succinate signaling attenuates high-fat diet-induced metabolic disturbance and intestinal barrier dysfunction)
作者：Xuan Li, Guowen Huang, Kaifan Yu* (Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, College of Animal Science and Technology, Nanjing Agricultural University, China)
17. wwl70诱导的ABHD6抑制可减轻APPswe/PS1dE9小鼠的记忆缺陷和病理表型
(Wwl70-induced ABHD6 inhibition attenuates memory deficits and pathological phenotypes in APPswe/PS1dE9 mice)
作者：Zhiwei Xue¹, Lei Ye¹, Jianwei Ge¹, Zhen Lan², Xiaolei Zhu¹* (1. Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, China; 2. Department of Neurology, Drum Tower Hospital of Nanjing Medical University, China)
18. 天然化合物穿心莲内酯降解MK2：一种抗炎治疗新途径
(Degradation of MK2 with natural compound andrographolide: A new modality for anti-inflammatory therapy)
作者：Quy T.N. Tran¹, Christina L.L. Chai²*, W.S. Fred Wong¹* (1. Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, Singapore; 2. Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore)
Editorial（述评）
1. 对抗亨廷顿舞蹈症的游戏规则改变者：胆固醇纳米颗粒恢复小鼠大脑功能
(Game-changer in the fight against Huntington's disease: Cholesterol nanoparticles restore brain function in mice)
作者：Mauricio G. Martín (Cellular and Molecular Neurobiology Department. Instituto Ferreyra (INIMEC)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-Universidad Nacional de Córdoba (UNC), Argentina)
Research article（研究文章）
1. 向大脑长期输入胆固醇有助于亨廷顿舞蹈症患者的认知和运动得到彻底和持久的改善
(Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington’s disease)
作者：Giulia Birolini, Marta Valenza*, Elena Cattaneo* (Department of Biosciences, University of Milan, Italy)

八、抗病毒研究（2023年第216卷）

August 2023 - Volume 216（2023年8月第216卷)
https://www.sciencedirect.com/journal/antiviral-research/vol/216/suppl/C

Research article（研究文章）
1. EVA1A通过增强HBV成分的细胞降解抑制HBV复制及其潜在的治疗应用
(Inhibition of HBV replication by EVA1A via enhancing cellular degradation of HBV components and its potential therapeutic application)
作者：Jie Yu, Zhongliang Shen* (Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, China)
2. 半工业规模生产的灭活单糖基化分离的H1N1流感病毒疫苗提供了针对流感病毒的跨株保护
(Pilot-scale production of inactivated monoglycosylated split H1N1 influenza virus vaccine provides cross-strain protection against influenza viruses)
作者：Chia-Ying Wu, Juine-Ruey Chen* (RuenHuei Biopharmaceuticals Inc. China)
3. 基于MDCK的高安全性和免疫保护的四价季节性流感病毒裂解疫苗的研制：临床前研究
(Development of MDCK-based quadrivalent split seasonal influenza virus vaccine with high safety and immunoprotection: A preclinical study)
作者：Jiayou Zhang, Zhongren Ma* (National Engineering Technology Research Center for Combined Vaccines, China; Lanzhou BaiLing Biotech Co., China)
4. 一种时空控制的重组cccDNA小鼠模型用于研究HBV和开发抗病毒药物
(A spatiotemporally controlled recombinant cccDNA mouse model for studying HBV and developing drugs against the virus)
作者：Zhongmin Zhou,  Wenhui Li * (College of Life Sciences, Beijing Normal University, China; National Institute of Biological Sciences, China)
5. 两种核苷酸类似物对人原代成纤维细胞中牛痘、猴痘和牛痘病毒的抗病毒活性
(Antiviral activities of two nucleos(t)ide analogs against vaccinia, mpox, and cowpox viruses in primary human fibroblasts)
作者：Lara Dsouza, Panayampalli S. Satheshkumar* (Department of Veterinary Pathobiology, School of Veterinary Medicine & Biomedical Sciences, Texas A&M University, USA; Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, USA)
6. 异噁唑-3-甲酰胺类似物对小鼠肠病毒D68和柯萨奇B5模型的疗效
(Efficacy of an isoxazole-3-carboxamide analog of pleconaril in mouse models of Enterovirus-D68 and Coxsackie B5)
作者：Thomas R. Lane¹, Jianing Fu², Sean Ekins¹* (1. Collaborations Pharmaceuticals Inc., USA; 2. Department of Biological Sciences, Purdue University, USA)
7. 将虚拟筛选与顺式/反式切割酶分析相结合，有效地揭示了靶向SARS-CoV-2和MERS-CoV主要蛋白酶的广谱抑制剂
(Combining virtual screening with cis-/trans-cleavage enzymatic assays effectively reveals broad-spectrum inhibitors that target the main proteases of SARS-CoV-2 and MERS-CoV)
作者：Yu-Jen Chang, Chih-Hao Lu* (The Ph.D. Program of Biotechnology and Biomedical Industry, China Medical University, Taichung, Taiwan)
8. 共表达修饰刺突蛋白和遗传佐剂的腺病毒载体疫苗经鼻给药可获得针对SARS-CoV-2的持久粘膜免疫
(Intranasal delivery of an adenovirus-vector vaccine co-expressing a modified spike protein and a genetic adjuvant confers lasting mucosal immunity against SARS-CoV-2)
作者：Hi Eun Jung, Heung Kyu Lee* (Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Korea)
9. 组织蛋白酶抑制剂硝基喹啉及其衍生物抑制SARS-CoV-2感染
(Cathepsin inhibitors nitroxoline and its derivatives inhibit SARS-CoV-2 infection)
作者：Rafaela Milan Bonotto, Janko Kos* (Laboratory of Molecular Virology, The International Centre for Genetic Engineering and Biotechnology (ICGEB), Italy; Department of Biotechnology, Jožef Stefan Institute, Slovenia)
10. Avasimibe可以与DC靶向和整合缺陷慢载体协同，通过调节胆固醇代谢诱导更强的HBV特异性T细胞毒性反应
(Avasimibe can cooperate with a DC-targeting and integration-deficient lentivector to induce stronger HBV specific T cytotoxic response by regulating cholesterol metabolism)
作者：Siyuan Ma*, Mengjiao Lv, Xiaohua Chen* (Department of Infectious Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, China)
11. 抑制免疫调节酰胺酶NAAA阻断人神经干细胞ZIKV成熟
(Inhibiting immunoregulatory amidase NAAA blocks ZIKV maturation in Human Neural Stem Cells)
作者：Michele Lai (Retrovirus Center, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy)
12. 在人乳头瘤病毒感染诱导的肿瘤发生的临床前模型中，MEK1/2抑制剂的抗病毒作用可促进肿瘤消退
(The antiviral effects of a MEK1/2 inhibitor promote tumor regression in a preclinical model of human papillomavirus infection-induced tumorigenesis)
作者：Adrian J. Luna, Michelle A. Ozbun* (Department of Molecular Genetics & Microbiology, The University of New Mexico School of Medicine, USA)
13. 猴痘病毒mRNA-lipid纳米颗粒候选疫苗在小鼠中引发抗体反应并驱动对牛痘病毒攻击的保护
(Mpox virus mRNA-lipid nanoparticle vaccine candidates evoke antibody responses and drive protection against the Vaccinia virus challenge in mice)
作者：Heng Xia, Yun-Ru He, Xiao-Yong Zhan*, Gao-Feng Zha* (The Seventh Affiliated Hospital, Sun Yat-sen University, China)
14. α -亚麻酸作为抗寨卡病毒、登革热、单纯疱疹病毒、流感病毒和SARS-CoV-2感染的广谱抗病毒药物的鉴定
(Identification of alpha-linolenic acid as a broad-spectrum antiviral against zika, dengue, herpes simplex, influenza virus and SARS-CoV-2 infection)
作者：Yifei Feng, Shuwen Liu*, Min Zou* (Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, China)
15. 循环Th2偏向性T滤泡辅助细胞通过上调CTLA4阻碍慢性乙型肝炎感染期间的抗病毒体液反应
(Circulating Th2-biased T follicular helper cells impede antiviral humoral responses during chronic hepatitis B infection through upregulating CTLA4)
作者：Shengxia Yin, Chao Wu* (Department of Infectious Diseases, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, China)
16. 评估宿主组织蛋白酶L蛋白酶抑制剂Z-FA-FMK作为抗SARS-CoV-2及相关冠状病毒的有效广谱抗病毒疗法
(Evaluating Z-FA-FMK, a host cathepsin L protease inhibitor, as a potent and broad-spectrum antiviral therapy against SARS-CoV-2 and related coronaviruses)
作者：Ju Hwan Jeong, Joo-Yeon Lee* (Department of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Korea)
17. Paxlovid治疗合并慢性肾脏病的COVID-19住院患者
(Paxlovid for hospitalized COVID-19 patients with chronic kidney disease)
作者：Hong Cai, Weibin Zhou* (Department of Nephrology, Molecular Cell Lab for Kidney Disease, Shanghai Peritoneal Dialysis Research Center, Ren Ji Hospital, Uremia Diagnosis and Treatment Center, Shanghai Jiao Tong University School of Medicine, China; Center for Translational Medicine and Pharmacology and Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, USA)
18. 奥司他韦和法匹拉韦联合应用对重症流感住院患者甲型流感病毒进化的影响
(The combined effect of oseltamivir and favipiravir on influenza A virus evolution in patients hospitalized with severe influenza)
作者：Shengrui Mu, Bin Cao* (Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Capital Medical University, China)
19. 大鼠戊型肝炎病毒粪口感染模型的建立及抗病毒研究的验证
(Establishment of a robust rat hepatitis E virus fecal-oral infection model and validation for antiviral studies)
作者：Xin Zhang, Johan Neyts*, Suzanne J.F. Kaptein* (KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Belgium)
20. 在JADE 2a期研究中，衣壳组装调节剂JNJ-56136379治疗慢性乙型肝炎患者的病毒序列分析
(Viral sequence analysis of chronic hepatitis B patients treated with the capsid assembly modulator JNJ-56136379 in the JADE phase 2a study)
作者：Thierry Verbinnen* (Janssen Pharmaceutica NV, Belgium)
21. 季节性冠状病毒感染触发巨噬细胞NLRP3炎性体激活，但可作为治疗靶点
(Seasonal coronavirus infections trigger NLRP3 inflammasome activation in macrophages but is therapeutically targetable)
作者：Yang Li, Yining Wang, Qiuwei Pan* (Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Netherlands)
Short communication（简报）
1. 猴痘甲基转移酶VP39对RNA-cap的识别和甲基化的结构基础
(Structural basis for RNA-cap recognition and methylation by the mpox methyltransferase VP39)
作者：Petr Skvara, Evzen Boura* (Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Czech Republic)
2. 预防先天性巨细胞病毒感染的新治疗视角
(New therapeutic perspective in the prevention of congenital cytomegalovirus infection)
作者：Perrine Coste Mazeau*, Sophie Alain* (University of Limoges, Inserm, France)
3. 启动晚期瑞德西韦治疗可保护部分非洲绿猴免受致命的尼帕病毒感染
(Late remdesivir treatment initiation partially protects African green monkeys from lethal Nipah virus infection)
作者：Emmie de Wit* (Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA)
4. SARS-CoV-2 奥密克戎变异株从RNA依赖性RNA聚合酶抑制剂和3c样蛋白酶抑制剂中逃逸的频率评估
(Assessment of the frequency of SARS-CoV-2 Omicron variant escape from RNA-dependent RNA polymerase inhibitors and 3C-like protease inhibitors)
作者：Emi Takashita* (Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan)
5. Ⅰ型乙型脑炎病毒作为外源基因表达的稳定病毒载体的评价
(Evaluation of the genotype I Japanese encephalitis virus as a stable viral vector for foreign gene expression)
作者：Chenxi Li, Yanhua Li* (College of Veterinary Medicine, Yangzhou University, China)
6. HSV1和HSV2病毒中新型UL23和UL30的替代与多态性或耐药性相关
(Novel UL23 and UL30 substitutions in HSV1 and HSV2 viruses related to polymorphism or drug resistance)
作者：J. Giorgi, E. Frobert* (Laboratoire de Virologie, Institut des Agents Infectieux, Hospices Civils de Lyon, Groupement Hospitalier Nord, France)

九、英国药理学杂志（2023年第180卷第15-16期）

（一）August 2023 - Volume 180 - Issue 15（2023年8月第180卷第15期)
https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2023/180/15

Invited Review（特邀综述）
1. 疟疾药理学进展和疟疾药理学在线指南：IUPHAR综述38
(Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38)
作者：Jane F. Armstrong, Brice Campo* (Deanery of Biomedical Sciences, The University of Edinburgh, UK; Medicines for Malaria Venture, Switzerland)
Research Articles（研究文章）
1. 一种通过诱导NLRP3蛋白降解作为高效抗炎剂的新型山梨糖苷类化合物
(A novel sorbicillinoid compound as a potent anti-inflammation agent through inducing NLRP3 protein degradation)
作者：Fangfang Wang* (Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drug Research, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, China)
2. 急性鼻内神经生长因子治疗限制了幼鼠创伤性脑损伤的发生
(Acute intranasal treatment with nerve growth factor limits the onset of traumatic brain injury in young rats)
作者：Luigi Manni, Marzia Soligo* (Institute of Translational Pharmacology, National Research Council of Italy (CNR), Italy)
3. 研发一种长效松弛素类似物LY3540378，用于治疗慢性心力衰竭
(Development of a long-acting relaxin analogue, LY3540378, for treatment of chronic heart failure)
作者：Petra Verdino* (Lilly Research Laboratories, Eli Lilly and Company, USA)
4. 微粒体前列腺素E合成酶-1的抑制作用可预防小鼠心肌梗死后的不良心脏重塑
(Microsomal prostaglandin E synthase-1 inhibition prevents adverse cardiac remodelling after myocardial infarction in mice)
作者：Yuze Zhang¹, Per-Johan Jakobsson²*, Miao Wang¹* (1. State Key Laboratory of Cardiovascular Disease and Clinical Pharmacology Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, China; 2. Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet and Karolinska University Hospital, Sweden)
5. 人ApoA-I-Milano变异体对老年转基因小鼠模型阿尔茨海默病的治疗作用
(Therapeutic effect of human ApoA-I-Milano variant in aged transgenic mouse model of Alzheimer's disease)
作者：Montse Solé*, Desheng Lu* (Neurovascular Research Laboratory, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona (UAB), Spain)
6. 罗布麻素对氧化应激的抑制作用可减轻香烟烟雾对慢性阻塞性肺病的进展和血管损伤
(Inhibition of oxidative stress by apocynin attenuated chronic obstructive pulmonary disease progression and vascular injury by cigarette smoke exposure)
作者：Stanley M. H. Chan, Ross Vlahos* (Centre for Respiratory Science and Health, School of Health and Biomedical Sciences, RMIT University, Australia)

（二）August 2023 - Volume 180 - Issue 16 （2023年8月第180卷第16期）
https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2023/180/16

Research Article（研究文章）
1. 通过Yoda1的4-苯甲酸修饰改进PIEZO1激动剂作用
(Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1)
作者：Gregory Parsonage¹, Richard Foster²*, David J. Beech¹* (1. Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, UK; 2. School of Chemistry, University of Leeds, UK)
2. Veklury®(瑞德西韦)制剂由于其磺基丁醚-β-环糊精含量而抑制SARS-CoV-2感染的初始膜偶联事件
(Veklury® (remdesivir) formulations inhibit initial membrane-coupled events of SARS-CoV-2 infection due to their sulfobutylether-β-cyclodextrin content)
作者：Tamas Kovacs, Florina Zakany* (Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Hungary)
3. 过氧化物酶体增殖体激活受体δ通过调节平滑肌细胞表型转换改善动脉粥样硬化斑块易感性的特征
(Peroxisome proliferator-activated receptor δ improves the features of atherosclerotic plaque vulnerability by regulating smooth muscle cell phenotypic switching)
作者：Chih-Feng Lien, Min-Chien Tsai* (Division of Cardiology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, China; Department of Physiology and Biophysics, Graduate Institute of Physiology, National Defense Medical Center, China)
4. 唾液链球菌的气道给药足以诱导大鼠实验性肺动脉高压
(Airway delivery of Streptococcus salivarius is sufficient to induce experimental pulmonary hypertension in rats)
作者：Chenting Zhang, Kai Yang*, Jian Wang* (National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangdong Key Laboratory of Vascular Disease, State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, China)
5. anteiso-C13-脂肽靶向甲酰肽受体1治疗中性粒细胞显性急性呼吸窘迫综合征
(Targeting formyl peptide receptor 1 with anteiso-C13-surfactin for neutrophil-dominant acute respiratory distress syndrome)
作者：Shun-Chin Yang, Tsong-Long Hwang* (Department of Anesthesiology, Taipei Veterans General Hospital and National Yang Ming Chiao Tung University, China; Graduate Institute of Natural Products and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, China)
6. RGS6负向调节多巴胺神经元中的抑制性G蛋白信号，正向调节小鼠的暴饮暴食
(RGS6 negatively regulates inhibitory G protein signaling in dopamine neurons and positively regulates binge-like alcohol consumption in mice)
作者：Margot C. DeBaker, Kevin Wickman* (Graduate Program in Neuroscience, University of Minnesota, USA; Department of Pharmacology, University of Minnesota, USA)
7. 绿原酸通过抑制KAT2A表达升高来减轻炎症以改善脂多糖诱导的急性肺损伤
(Chlorogenic acid reduces inflammation by inhibiting the elevated expression of KAT2A to ameliorate lipopolysaccharide-induced acute lung injury)
作者：Bin Lv, Xiaoying Wang*, Xiumei Gao* (Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, China)
8. 帕博西尼阻断中性粒细胞磷脂酰肌醇3-激酶活性缓解银屑病样皮炎
(Palbociclib blocks neutrophilic phosphatidylinositol 3-kinase activity to alleviate psoriasiform dermatitis)
作者：Po-Jen Chen, Tsong-Long Hwang* (Department of Medical Research, E-DA Hospital, I-Shou University, China; Graduate Institute of Natural Products, School of Traditional Chinese Medicine, Chang Gung University, China)

十、临床药代动力学（2023年第62卷第8期）

August 2023 -Volume 62 - Issue 8（2023年8月第62卷第8期)
https://link.springer.com/journal/40262/volumes-and-issues/62-8

Review Article（综述文章）
1. 新一代雄激素受体抑制剂达罗他胺的临床药代动力学和药效学研究
(Clinical Pharmacokinetics and Pharmacodynamics of the Next Generation Androgen Receptor Inhibitor—Darolutamide)
作者：Eva Podgoršek, Nielka P. van Erp* (Department of Clinical Pharmacy, Radboud University Medical Center, The Netherlands)
2. 布加替尼的临床药理学：新一代变性淋巴瘤激酶抑制剂
(Clinical Pharmacology of Brigatinib: A Next-Generation Anaplastic Lymphoma Kinase Inhibitor)
作者：Neeraj Gupta* (Takeda Development Center Americas, Inc., USA))
Original Research Article（原创研究文章）
1. 兔抗胸腺细胞球蛋白在接受治疗恶性血液系统肿瘤造血细胞移植的非肥胖成年患者中的群体药代动力学
(Population Pharmacokinetics of Total Rabbit Anti-thymocyte Globulin in Non-obese Adult Patients Undergoing Hematopoietic Cell Transplantation for Hematologic Malignancy)
作者：Takuto Takahashi* (Pediatric Stem Cell Transplantation, Boston Children’s Hospital/Dana Farber Cancer Institute, USA)
2. 加格列净在中国2型糖尿病合并肾损害患者中的药代动力学、药效学和安全性
(Pharmacokinetics, Pharmacodynamics and Safety of Janagliflozin in Chinese Type 2 Diabetes Mellitus Patients with Renal Impairment)
作者：Hengli Zhao, Shuguang Pang* (Department of Clinical Research Center, Central Hospital Affiliated to Shandong First Medical University, China; Department of Endocrinology, Central Hospital Affiliated to Shandong First Medical University, China)
3. 机器学习在新生儿万古霉素剂量个体化中的应用
(Use of Machine Learning for Dosage Individualization of Vancomycin in Neonates)
作者：Bo-Hao Tang, Wei Zhao* (Department of Clinical Pharmacy, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, China)
4. 同时描述肾和肺移植受者血浆和全血他克莫司浓度的联合药代动力学模型
(A Joint Pharmacokinetic Model for the Simultaneous Description of Plasma and Whole Blood Tacrolimus Concentrations in Kidney and Lung Transplant Recipients)
作者：Jeroen V. Koomen* (Department of Anaesthesiology, University of Groningen, University Medical Center Groningen, The Netherlands)
5. 癌症患者CYP3A4*22基因型引导的激酶抑制剂剂量
(CYP3A4*22 Genotype-Guided Dosing of Kinase Inhibitors in Cancer Patients)
作者：Ruben A. G. van Eerden, Nikki S. IJzerman, Naomi Ketharanathan* (Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, The Netherlands)
6. 肝硬化患者UDP -葡萄糖醛基转移酶UGT1A和UGT2B亚家族成员的活性受损
(The Activity of Members of the UDP-Glucuronosyltransferase Subfamilies UGT1A and UGT2B is Impaired in Patients with Liver Cirrhosis)
作者：Urs Duthaler, Fabio Bachmann, Stephan Krähenbühl* (Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Switzerland)
7. 半生理富集群体药代动力学模型预测妊娠对细胞毒性药物药代动力学的影响
(Semi-physiological Enriched Population Pharmacokinetic Modelling to Predict the Effects of Pregnancy on the Pharmacokinetics of Cytotoxic Drugs)
作者：J. M. Janssen, T. P. C. Dorlo* (Department of Pharmacy and Pharmacology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, The Netherlands)
8. 绝经前妇女单独使用瑞卢戈利或瑞卢戈利联合治疗的随机开放标签研究
(A Randomized Open-Label Study of Relugolix Alone or Relugolix Combination Therapy in Premenopausal Women)
作者：Andrea Lukes, Elizabeth Migoya* (Carolina Women’s Research and Wellness Center, USA; Myovant Sciences, Inc., USA)