一、临床药理学与治疗学 (2025年第117卷第5期)

May 2025 - Volume 117 - Issue 5（2025年5月第117卷第5期） 

https://ascpt.onlinelibrary.wiley.com/toc/15326535/2025/117/5

Editorial（社论）
1.磁共振成像揭示比沙可啶(双醋苯啶)药理作用新机制：理解肠道药物作用的蓝图
MRI Provides New Insights Into the Pharmacologic Mechanism of Bisacodyl: A Blueprint for Understanding Intestinal Drug Mechanisms
Kathleen M. Giacomini
Perspective（观点）
2.日本再生医学有条件/限时早期批准体系：自体骨骼肌成肌细胞薄片疗法的兴衰案例
Japan's Conditional/Time-Limited Early Approval System in Regenerative Medicine: A Case Study of Rise and Falls of Autologous Skeletal Myoblast Sheets
Hayase Hakariya,  Akihiko Ozaki,  Yudai Kaneda,  Tetsuya Tanimoto
3.环孢素作为OATP1B指数抑制剂替代利福平的挑战与应对
Navigating the Challenges of Cyclosporine as an Alternative to Rifampicin as an OATP1B Index Inhibitor
Manthena V. S. Varma,  Manoli Vourvahis
4.提升患者护理的综合证据规划：释放真实世界证据的力量
Integrated Evidence Planning for Enhancing Patient Care: Harnessing the Power of Real-World Evidence
Gorana Capkun,  Melvin (Skip) Olson
Commentary（评论）
5.新生儿阿片戒断综合征药物治疗：最优药物、最优剂量还是两者兼得？
Optimal Drug, Optimal Dose, or Both in the Pharmacological Treatment of Neonatal Opioid Withdrawal Syndrome?
Walter K. Kraft
White Paper（白皮书）
6.2024年美国FDA将部分曲线下面积纳入生物利用度和生物等效性评估的最新进展
A 2024 Update on US FDA Implementation of Partial Area Under the Curve Into Bioavailability and Bioequivalence Assessments
Robert Hopefl,  Yuqing Gong,  Elizabeth Bielski,  Venkateswaran C Pillai,  Bryan Newman,  Bin Qin,  Yan Wang,  Miyoung Yoon,  Qiangnan Zhang,  Ethan Stier,  Ramana Uppoor,  Hao Zhu,  Lei Zhang,  Lanyan Fang
Tutorial（指南）
7.系统性氟嘧啶类药物DPYD基因分型临床实践指南
A Guide for Implementing DPYD Genotyping for Systemic Fluoropyrimidines into Clinical Practice
Teresa T. Ho, D. Max Smith, Christina L. Aquilante, Emily J. Cicali, Nihal El Rouby, Daniel L. Hertz, Iman Imanirad, Jai N. Patel, Stuart A. Scott, Sandra M. Swain, Sony Tuteja, J. Kevin Hicks,  on behalf of the Pharmacogenomics Global Research Network Publication Committee
Review（综述）
State of the Art Review（前沿综述）
8.利用真实世界数据表征治疗效应异质性
Characterizing Treatment Effect Heterogeneity Using Real-World Data
Haedi Thelen,  Sean Hennessy
Review（综述）
9.极光激酶在肾脏疾病中的作用机制
The Role and Mechanisms of Aurora Kinases in Kidney Diseases
Meiying Chang,  Qiuyi Li,  Zhenwei Shi,  Shougang Zhuang
Systematic Review（系统综述）
10.基于生物标志物的患者选择方法学见解：欧洲药品管理局科学建议程序回顾
Methodological Insights on Biomarker-Based Patient Selection: A Review of Scientific Advice Procedures at the European Medicines Agency
Cynthia Huber,  Joerg Zinserling,  Norbert Benda,  Thorsten Vetter,  Marcia Rueckbeil
11.机器学习预测药物浓度的应用与挑战
Machine Learning for Prediction of Drug Concentrations: Application and Challenges
Shuqi Huang,  Qihan Xu,  Guoping Yang,  Junjie Ding,  Qi Pei
Research（研究）
Brief Report（简要报告）
12.新型三联复方抗疟疗法(蒿甲醚-本芴醇-阿莫地喹)的剂量优化
Dose-Optimization of a Novel Co-Formulated Triple Combination Antimalarial Therapy: Artemether-Lumefantrine-Amodiaquine
Joel Tarning,  Nicholas J. White,  Arjen M. Dondorp
Article（文章）
13.可乐定治疗新生儿阿片戒断综合征的药代动力学建模与剂量优化假设生成
Pharmacokinetic Modeling and Model-Based Hypothesis Generation for Dose Optimization of Clonidine in Neonates With Neonatal Opioid Withdrawal Syndrome
Fei Tang,  Chee M. Ng,  Jamie Horn,  Henrietta S. Bada,  Markos Leggas
14.细胞与基因治疗产品的临床开发路径图谱
Mapping the Clinical Development Trajectory of Cell and Gene Therapy Products
Magdi Elsallab,  Michelle Ouvina,  Andrea Arfe,  Florence T. Bourgeois
15.健康人群及肾毒性和缺血性损伤后的尿肾损伤生物标志物特征
Urinary Kidney Injury Biomarker Profiles in Healthy Individuals and After Nephrotoxic and Ischemic Injury
Sushrut S. Waikar,  Robin Mogg,  Amanda F. Baker,  Gyorgy Frendl,  Michael Topper,  Scott Adler,  Stefan Sultana,  Runqi Zhao,  Nicholas M. P. King,  Steven P. Piccoli,  John-Michael Sauer,  Steve Hoffmann,  Irene Nunes,  Frank D. Sistare
16.磁共振成像揭示比沙可啶双重作用机制：便秘治疗的随机安慰剂对照试验
Magnetic Resonance Imaging Reveals Novel Insights into the Dual Mode of Action of Bisacodyl: A Randomized, Placebo-controlled Trial in Constipation
Abdulsalam Aliyu,  Neele Dellschaft,  Caroline Hoad,  Hannah Williams,  Emily Gaudoin,  Sarah Sulaiman,  Colin Crooks,  Penny Gowland,  Alexia Aran,  Robert Lange,  Beatrice Bois De Fer,  Maura Corsetti,  Luca Marciani,  Robin Spiller
17.基于模型的贝达喹啉和德拉马尼在儿童、青少年及成人结核病患者中的每日一次给药策略
Model-Informed Once-Daily Dosing Strategy for Bedaquiline and Delamanid in Children, Adolescents and Adults with Tuberculosis
Yu-Jou Lin,  Louvina E. van der Laan,  Mats O. Karlsson,  Anthony J. Garcia-Prats,  Anneke C. Hesseling,  Elin M. Svensson
18.微剂量鸡尾酒研究揭示终末期肾病患者OATP1B、P-gp、BCRP和CYP3A活性及其关键影响因素
Microdose Cocktail Study Reveals the Activity and Key Influencing Factors of OATP1B, P-Gp, BCRP, and CYP3A in End-Stage Renal Disease Patients
Weijie Kong,  Yuejuan Pan,  Yujie Wu,  Yiyi Hu,  Zhenbin Jiang,  Xinkui Tian,  Shuhong Bi,  Song Wang,  Feifei Feng,  Yuyan Jin,  Jiayu Li,  Haiyan Li,  Yue Wang,  Hao Liang,  Wen Tang,  Dongyang Liu
19.非洲裔美国人氯吡格雷反应性的基因组与转录组风险因素研究
Investigation of Genomic and Transcriptomic Risk Factors of Clopidogrel Response in African Americans
Guang Yang,  Cristina Alarcon,  Catherine Chanfreau,  Norman H. Lee,  Paula Friedman,  Edith Nutescu,  Matthew Tuck,  Travis O'Brien,  Li Gong,  Teri E. Klein,  Kyong-Mi Chang,  Philip S. Tsao,  David O. Meltzer,  Julie A. Lynch,  Million Veteran Program ,  Sony Tuteja,  Minoli A. Perera
20.日本罕见病研发格局演变：孤儿药滞后的日益关注
Evolving Research and Development Landscape for Rare Diseases: Growing Concerns Over Orphan Drug Lag in Japan
Kazuaki Enya,  Itsuki Kageyama,  Yoshiyuki Kobayashi,  Yeongjoo Lim,  Shintaro Sengoku,  Kota Kodama
21.撒哈拉以南非洲人群NAT、GST和CYP2E1基因变异特征及其对结核等疾病治疗的意义
Characterization of NAT, GST, and CYP2E1 Genetic Variation in Sub-Saharan African Populations: Implications for Treatment of Tuberculosis and Other Diseases
Thandeka V.B. Malinga,  Houcemeddine Othman,  Maria Paximadis,  Caroline T. Tiemessen,  Michèle Ramsay,  Scott Hazelhurst,  David Twesigomwe
22.靶向介导处置对Iptacopan在肝功能正常或受损受试者中药代动力学的影响
Effect of Target-Mediated Disposition on Iptacopan Clinical Pharmacokinetics in Participants with Normal or Impaired Hepatic Function
Elise Burmeister Getz,  Richard R. Stein,  Martin Fink,  Kenneth Kulmatycki,  Irina Baltcheva,  Wendy Weis,  Bharti Shah,  Eric Lawitz,  Robert Schmouder
23.细胞因子动态作用机制：评估IL-6相关治疗性蛋白-药物-疾病相互作用的方法学
Cytokine Dynamics in Action: A Mechanistic Approach to Assess Interleukin 6 Related Therapeutic Protein-Drug–Disease Interactions
Xian Pan,  Katherine L. Gill,  Amita Pansari,  Oliver Hatley,  Liam Curry,  Masoud Jamei,  Iain Gardner
24.孕期流感疫苗接种与母婴健康结局的关联：基于人群的队列研究
Association of Influenza Vaccination During Pregnancy with Health Outcomes in Mothers and Children: A Population-Based Cohort Study
Hyesung Lee,  Dongwon Yoon,  Ju Hwan Kim,  Yunha Noh,  Eun-Jeong Joo,  Jung Yeol Han,  Young June Choe,  Ju-Young Shin
25.阿扎那韦、利托那韦和多替拉韦与利福平合用的细胞内渗透性：剂量递增研究
Intracellular Penetration of Atazanavir, Ritonavir and Dolutegravir With Concomitant Rifampicin: A Dose Escalation Study
Amedeo De Nicolò,  Alice Palermiti,  Henry Mugerwa,  Shamim Nakabuye,  Josephine Namusanje,  Josephine Kobusingye,  Denis Odoch,  Mohammed Lamorde,  Allan Kengo,  Paolo Denti,  Kamunkhwala Gausi,  Gary Maartens,  Helen McIlleron,  Lubbe Wiesner,  Saye Khoo,  Catriona Waitt,  Antonio D'Avolio
26.口服抗病毒药物Obeldesivir的药物相互作用临床评估
Clinical Evaluation of Drug–Drug Interactions with Obeldesivir, an Orally Administered Antiviral Agent
Chi-Chi Peng,  Rita Humeniuk,  Anuja Raut,  Anna Kwan,  Lily Mak,  Caitlin Stacom,  Deqing Xiao,  Shuguang Chen,  Santosh Davies,  Sharline Madera,  Yiannis Koullias,  Amos Lichtman,  Joe Llewellyn,  Elham Amini,  Helen Winter,  Luzelena Caro
27.基于模型预测异基因造血干细胞移植后临床相关血小板减少症
Model-Based Prediction of Clinically Relevant Thrombocytopenia after Allogeneic Hematopoietic Stem Cell Transplantation
Katharina M. Götz,  Amin T. Turki,  Katharina Och,  Dominik Selzer,  Christian Brossette,  Norbert Graf,  Jochen Rauch,  Stefan Theobald,  Yvonne Braun,  Kerstin Rohm,  Gabriele Weiler,  Simeon Rüdesheim,  Matthias Schwab,  Lisa Eisenberg,  Nico Pfeifer,  Stephan Kiefer,  Ulf Schwarz,  Claudia Riede,  Sigrun Smola,  Dietrich W. Beelen,  Dominic Kaddu-Mulindwa,  Jürgen Rissland,  Jörg Bittenbring,  Thorsten Lehr
28.CB1受体拮抗剂Selonabant (ANEB-001)阻断健康志愿者急性THC效应的II期随机对照试验
CB1 Receptor Antagonist Selonabant (ANEB-001) Blocks Acute THC Effects in Healthy Volunteers: A Phase II Randomized Controlled Trial
Andriy A. Gorbenko,  Jules A. A. C. Heuberger,  Maria Juachon,  Erica Klaassen,  Michael Tagen,  Joseph F. Lawler,  Daniel Schneeberger,  Kenneth C. Cundy,  Linda E. Klumpers,  Geert J. Groeneveld
29.复发或难治性大B细胞淋巴瘤皮下双特异性抗体Epcoritamab的最佳给药方案
Optimal Dosing Regimen for Epcoritamab, a Subcutaneous Bispecific Antibody, in Relapsed or Refractory Large B-Cell Lymphoma
Tommy Li,  Leonid Gibiansky,  Apurvasena Parikh,  Matthew Putnins,  Christopher W. Chiu,  Mariana Sacchi,  Huaibao Feng,  Tahamtan Ahmadi,  Manish Gupta,  Steven Xu
30.基于模型选择抗TIGIT免疫治疗的II期推荐剂量：利用共表达PD-1抑制剂靶点占位
Model-Informed Selection of the Recommended Phase 2 Dosage for Anti-TIGIT Immunotherapy Leveraging co-Expressed PD-1 Inhibitor Target Engagement
Irina Kareva,  Ping Hu,  Vadryn Pierre,  Thomas Kitzing,  Anja Victor,  Emilia Richter,  Wei Gao,  Karthik Venkatakrishnan,  Anup Zutshi
31.早期帕金森病患者生物标志物导向的临床终点模型建立
Establishment of a Biomarker-Directed Clinical Endpoint Model for Early-Stage Parkinson's Disease Patients
Churni Gupta,  Chaejin Kim,  Serge Guzy,  Tomoki Yoneyama,  Hamidreza Gharahi,  Vijay Kumar Siripuram,  Sergio Iadevaia,  Dipak Barua,  Yaming Hang,  Tatiana Iakovleva,  Christina Boucher,  Majid Vakilynejad,  Stephan Schmidt,  Valvanera Vozmediano

二、药理学评论 

May 2025 - Volume 77 - Issue 3 （2025年5月第77卷第3期）

https://pharmrev.aspetjournals.org/issue/S0031-6997(25)X0004-1

Perspective（观点）
1.基尔霍夫定律在药理学和药代动力学分析中的应用
Application of Kirchhoff’s Laws to pharmacologic and pharmacokinetic analyses
Leslie Z. Benet, Jasleen K. Sodhi, Markus Ville Tiitto, Yue Xiang
IUPHAR Nomenclature Report（IUPHAR命名报告）
2.国际基础与临床药理学联合会CXIX报告：肉碱棕榈酰转移酶家族酶的基础认知与临床意义
International Union of Basic and Clinical Pharmacology. CXIX. Fundamental insights and clinical relevance regarding the carnitine palmitoyltransferase family of enzymes
Rosalía Rodríguez-Rodríguez, Miguel Baena, Sebastián Zagmutt,...Ana Cristina Reguera, Rut Fadó, Núria Casals
Review Articles（综述文章）
3.血红素硫醇单加氧酶细胞色素P450 1B1：老酶新用
Heme-thiolate monooxygenase cytochrome P450 1B1, an old dog with many new tricks
Jong-Won Kim, Hung-Chun Tung, Bin Yang,...Xiuchen Guan, Ye Feng, Wen Xie
4.治疗安全性：妊娠期母体抑郁焦虑的经典药物治疗与新途径
Safety in treatment: Classical pharmacotherapeutics and new avenues for addressing maternal depression and anxiety during pregnancy
Merel Dagher, Catherine M. Cahill, Anne M. Andrews
5.环核苷酸磷酸二酯酶作为药物靶点
Cyclic nucleotide phosphodiesterases as drug targets
Michy P. Kelly, Viacheslav O. Nikolaev, Leila Gobejishvili,...Rick H. Cote, Soroush Mohammadi Jouabadi, Anton J.M. Roks
6.对数正态数据分析：非数学实用指南
Analyzing lognormal data: A nonmathematical practical guide
Harvey J. Motulsky, Trajen Head, Paul B.S. Clarke
7.激活自噬清除神经退行性疾病中有毒蛋白聚集物的小分子策略
Activating autophagy to eliminate toxic protein aggregates with small molecules in neurodegenerative diseases
Yuqi Fu, Jin Zhang, Rui Qin, ...Tingting Zhou, Bo Han, Bo Liu
8.健康与阿尔茨海默病中的微循环、血脑屏障及神经血管单元：异常周细胞的核心作用
The microcirculation, the blood-brain barrier, and the neurovascular unit in health and Alzheimer disease: The aberrant pericyte is a central player
Yasmin Amy Divecha, Sanketh Rampes, Sabine Tromp, ...Alice Fleckney, Mehmet Fidanboylu, Sarah Ann Thomas
9.冷冻电镜技术解析人类A类孤儿GPCR激活机制
Cryoelectron microscopy as a tool for illuminating activation mechanisms of human class A orphan G protein-coupled receptors
Isabella C. Russell, Dongju Lee, Denise Wootten, Patrick M. Sexton, Fabian Bumbak

三、先进药物输送评论（2025年第220卷） 

May 2025 - Volume 220 （2025年5月第220卷）

https://www.sciencedirect.com/journal/advanced-drug-delivery-reviews/vol/220/suppl/C

Editorial（社论）
1.靶向肿瘤相关微生物组：肿瘤微环境调控的癌症治疗新视角
Targeting tumor-associated microbiome: A new aspect of modulating tumor microenvironment for cancer therapy
Wantong Song, Leaf Huang
Review article（综述文章）
2.声镊技术在靶向药物递送中的应用
Acoustic tweezers for targeted drug delivery
Léa Guerassimoff, Stefaan C. De Smedt, Félix Sauvage, Michael Baudoin
3.日本MIDD（模型引导的药物研发）实践：实施、挑战与机遇
MIDD in Japan– Implementations, challenges and opportunities
Mayumi Hasegawa, Shinichi Kijima
4.光学相干断层扫描技术在药物递送无创监测中的应用
Optical coherence tomography for noninvasive monitoring of drug delivery
Salavat R. Aglyamov, Kirill V. Larin
5.调控石墨炔基纳米材料的电子结构以设计生物医学应用中的纳米-生物界面
Modulating the electronic structure of graphdiyne-based nanomaterials for engineering nano-bio interfaces in biomedical applications
Hui Wang, Xiaoyu Zhang, Jing Liu, Chunying Chen
6.靶向中枢生物钟的纳米颗粒：神经系统疾病的潜在治疗应用
Nanoparticles targeting the central circadian clock: Potential applications for neurological disorders
Marion Le Meur, Jaime Pignatelli, Paolo Blasi, Valle Palomo
7.鼻内NAP（达文肽）给药：神经保护与昼夜节律调节
Intranasal NAP (Davunetide): Neuroprotection and circadian rhythmicity
Artur Galushkin, Illana Gozes
8.靶向神经退行性疾病昼夜节律紊乱的鼻内与吸入给药系统：前景与未来展望
Intranasal and inhaled delivery systems for targeting circadian dysfunction in neurodegenerative disorders, perspective and future outlook
Rhearne Ryan, Mathew N. Leslie, Patrick He, Paul M. Young, ... Daniela Traini
9.突破口腔黏膜屏障的治疗性肽给药装置
Devices to overcome the buccal mucosal barrier to administer therapeutic peptides
Sahil Malhotra, Thomas Lijnse, Eoin O’ Cearbhaill, David J. Brayden

四、药理学发展趋势 (2025年第46卷第5期)

May 2025 - Volume 46 - Issue 5（2025年5月第46卷第5期）
https://www.cell.com/trends/pharmacological-sciences/issue?pii=S0165-6147(25)X0005-5

Spotlight（聚焦）
1.KRASG12C/mTORC1双重抑制：NSCLC治疗的强力组合
KRASG12C/mTORC1 inhibition: a powerful duo in NSCLC therapeutics
Antonios N. Gargalionis, Kostas A. Papavassiliou, Athanasios G. Papavassiliou
Opinions（观点）
2.三氟拉嗪在胶质母细胞瘤治疗中的老药新用
Repurposing trifluoperazine for glioblastoma treatment
Manam Inushi De Silva, Hui K. Gan, Cedric Bardy
3.调控钙稳态的毒液肽：神经保护潜力
Venom peptides regulating Ca2+ homeostasis: neuroprotective potential
Jessica A.I. Muller, Lachlan A. Bourke, Sam I.D. Campbell, Fernanda C. Cardoso
Reviews（综述）
4.GLP-1受体信号通路的结构药理学与作用机制
Structural pharmacology and mechanisms of GLP-1R signaling
Qingtong Zhou, Fenghui Zhao, Yao Zhang, Dehua Yang, Ming-Wei Wang
5.CRISPR/Cas技术在癌症药物研发与治疗中的应用
CRISPR/Cas technologies for cancer drug discovery and treatment
Kevin C. Wang, Tiffany Zheng, Basil P. Hubbard
6.BiP与Grp94的结构功能动态特性：治疗发现新机遇
The structural and functional dynamics of BiP and Grp94: opportunities for therapeutic discovery
Ikponwmosa Obaseki, Chioma C. Ndolo, Ayodeji A. Adedeji, Hannah O. Popoola, Andrea N. Kravats
7.通过生物体液中的脑源性外泌体监测神经退行性病变
Monitoring neurodegeneration through brain-derived extracellular vesicles in biofluids
Francesca Torrini,Marcos Gil-Garcia, Jacopo Cardellini, Roberto Frigerio, Manuela Basso, Alessandro Gori, Paolo Arosio
Drug of the Month（本月药物）
8.苏泽曲近(Suzetrigine)用于中重度急性疼痛治疗
Suzetrigine for moderate to severe acute pain
Eun Bee Cho, Chenyao Jiang, Zihan Wang, Ying Yu, Jianxiong Jiang

五、药理学与治疗学 (2025年第269卷)

May 2025 - Volume 269 （2025年5月第269卷）
https://www.sciencedirect.com/journal/pharmacology-and-therapeutics/vol/269/suppl/C

Review article（综述文章）
1.GLP-1受体激动剂：我们是否正在见证神经-心脏-代谢疾病治疗范式的转变？
GLP-1 receptor agonists, are we witnessing the emergence of a paradigm shift for neuro-cardio-metabolic disorders?
Abdelilah Arredouani
2.焦虑障碍与PTSD中的（神经）炎症系统：潜在治疗靶点
The (neuro)inflammatory system in anxiety disorders and PTSD: Potential treatment targets
Anupam Sah, Nicolas Singewald
3.巨噬细胞在哮喘相关纤维化与重塑中的作用
The role of macrophages in asthma-related fibrosis and remodelling
Xin Yuan Yang, Fuguang Li, Guojun Zhang, Paul S. Foster, Ming Yang
4.天然产物靶标鉴定技术的最新进展
Recent advances in target identification technology of natural products
Ting-Ting Liu, Ke-Wu Zeng
5.天然产物来源的神经免疫调节剂：作用机制与潜在疗法
Neuroimmune modulators derived from natural products: Mechanisms and potential therapies
Wan-Di Feng, Dong-Ni Liu, Yu-Fu Shang, Wen-Fang Zhang, ... Yue-Hua Wang
6.天然草药中皂苷的抗炎作用
The anti-inflammatory effects of saponins from natural herbs
Qinpin Zheng, Tian Wang, Sensen Wang, Zhuoxi Chen, ... Fenghua Fu
7.改善慢性代谢炎症与调节肠道稳态：茶作为潜在疗法
Improvement of chronic metabolic inflammation and regulation of gut homeostasis: Tea as a potential therapy
Shiyi Yu, Xuan Zhu, Xiayu Zhao, Yan Li, ... Jian Ying
8.G蛋白偶联雌激素受体偏向性信号在健康与疾病中的作用
G protein-coupled estrogen receptor biased signaling in health and disease
Aisha Bushi, Yixuan Ma, Joseph Adu-Amankwaah, Rong Wang, ... Rubin Tan
9.多肽-GPCR偏向性激动：结构视角
Biased agonism in peptide-GPCRs: A structural perspective
Tharindunee Jayakody, Dinath Kavishka Budagoda, Krishan Mendis, Withanage Dhanuka Dilshan, ... Gavin Stewart Dawe
10.受体二聚化与偏向性配体：靶向GPCR的新策略
Receptor dimers and biased ligands: Novel strategies for targeting G protein-coupled receptors
Wenkai Liu, Dexiu Wang, Luoqi Wang, Shujuan Hu, ... Jing Chen
11.成纤维细胞生长因子受体信号在代谢功能障碍相关脂肪肝病中的作用：发病机制与治疗靶点
Fibroblast growth factor receptor signaling in metabolic dysfunction-associated fatty liver disease: Pathogenesis and therapeutic targets
Yi Chu, Su Yang, Xiaodong Chen
12.炎症性肠病与神经精神障碍：微生物-肠-脑轴机制与新兴疗法
Inflammatory bowel disease and neuropsychiatric disorders: Mechanisms and emerging therapeutics targeting the microbiota-gut-brain axis
Giulia Petracco, Isabella Faimann, Florian Reichmann
13.蛋白磷酸酶2A（PP2A）的调控机制：药理调节剂与潜在治疗策略
Understanding the regulatory landscape of protein phosphatase 2A (PP2A): Pharmacological modulators and potential therapeutics
David A. Neale, Jonathan C. Morris, Nicole M. Verrills, Alaina J. Ammit
14.植物源性纳米囊泡及其治疗应用
Plant-derived nanovesicles and therapeutic application
Dokyung Jung, Na-Eun Kim, Sua Kim, Ju-Hyun Bae, ... Moon-Chang Baek

六、药物 (2025年第85卷第5期)

May 2025 - Volume 85 - Issue 5（2025年5月第85卷第5期）
https://link.springer.com/journal/40265/volumes-and-issues/85-5

Current Opinion（当前观点）
1.定制化生物类似药策略：预期与要求
The Tailored Biosimilar Approach: Expectations and Requirements
Elena Guillen, Sean Barry… Nadine KirschStefan
Leading Article（重点文章）
2.经典致幻剂治疗抑郁症：潜在获益与挑战
Classic Psychedelics for the Treatment of Depression: Potential Benefits and Challenges
Sharmin Ghaznavi & Sarah G. Richter
Review Article（综述文章）
3.全球新型降脂药：PCSK9第三单抗——托法利单抗(Tafolecimab)述评
Tafolecimab, a Third Monoclonal Antibody for PCSK9 as the Novel Lipid-Lowering Drug Around the World: A Narrative Review
Hui-Hui Liu, Sha Li & Jian-Jun Li
4.急性与复发性心包炎的当前药物治疗方案 
Current Drug Treatment for Acute and Recurrent Pericarditis
Aldo Bonaventura, Davide Santagata … Antonio Abbate
5.RNA疗法在心血管疾病治疗中的潜力
The Potential of RNA Therapeutics in Treating Cardiovascular Disease
Gayatri Mainkar, Matteo Ghiringhelli & Lior Zangi
Systematic Review（系统综述）
6.成人神经源性下尿路功能障碍无创与膀胱内治疗的有效性与安全性：随机对照试验的系统综述与网状Meta分析
Efficiency and Safety of Noninvasive and Intravesical Therapy for Adult Neurogenic Lower Urinary Tract Dysfunction: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials

Qiang Wang, Canyong Li… Hongxing Huang
AdisInsight Report（AdisInsight报告）
7.科西贝利单抗(Cosibelimab)：首次获批
Cosibelimab: First Approval
Arnold Lee
8.伊帕木单抗(Iparomlimab)与妥凡利单抗(Tuvonralimab)：首次获批
Iparomlimab and Tuvonralimab: First Approval
Susan J. Keam
9.扎尼达单抗(Zanidatamab)：首次获批
Zanidatamab: First Approval
Susan J. Keam
10.司泊奇单抗(Stapokibart)：首次获批
Stapokibart: First Approval
Matt Shirley

七、药理学研究 (2025年第215卷)

May 2025 - Volume 215（2025年5月第215卷）
https://www.sciencedirect.com/journal/pharmacological-research/vol/215/suppl/C

Review Articles（综述文章）
1.CBX4调控衰老及相关疾病的分子通路与机制
CBX4 regulation of senescence and associated diseases: Molecular pathways and mechanisms
Qianxing Hu, Linming Su, Wanli Zhao, Yinuo Jin, ... Fangfang Zhang
2.肢端黑色素瘤中端粒酶与端粒功能障碍的调控策略
Managing telomerase and telomere dysfunction in acral melanoma
Vishnu Sravan Bollu, Yu-Chi Chen, Fan Zhang, Krishne Gowda, ... Gavin P. Robertson
3.IUPHAR综述：从肠道到大脑——肠道菌群失调、细菌淀粉样蛋白与代谢疾病在阿尔茨海默病中的作用
IUPHAR review: From gut to brain: The role of gut dysbiosis, bacterial amyloids, and metabolic disease in Alzheimer’s disease
Saadet Inan, R. Paul Wilson, Çagla Tükel
4.可变剪接在T细胞应答和癌症免疫治疗中的关键调控作用
Alternative splicing: A key regulator in T cell response and cancer immunotherapy
Caiyu Yong, Yexin Liang, Minmin Wang, Weiwei Jin, ... Cunjie Chang
5.帕金森病焦虑抑郁的多维度机制：整合神经影像、神经环路与分子通路
Multidimensional mechanisms of anxiety and depression in Parkinson’s disease: Integrating neuroimaging, neurocircuits, and molecular pathways
Jihu Zhao, Huafang Jia, Pengju Ma, Deyuan Zhu, Yibin Fang
6.代谢失衡与脑肿瘤：抗糖尿病药物的代谢通路交叉与治疗作用
Metabolic imbalance and brain tumors: The interlinking metabolic pathways and therapeutic actions of antidiabetic drugs
Young-Kook Kim, Juhyun Song
7.线粒体质量控制：中医药治疗心血管疾病的新靶点
Mitochondrial quality control: A promising target of traditional Chinese medicine in the treatment of cardiovascular disease
Deng Pan, Pengfei Chen, He Zhang, Qian Zhao, ... Tielong Chen
8.冷大气等离子体通过靶向FTO蛋白调控代谢综合征
Cold atmospheric plasma control metabolic syndromes via targeting fat mass and obesity-associated protein
Xiaofeng Dai, Shuo Feng, Tian Li
9.肠道菌群重塑三阴性乳腺癌免疫微环境：新兴免疫治疗策略
Gut microbiota reshapes the TNBC immune microenvironment: Emerging immunotherapeutic strategies
Mingyao Huang, Yikai Zhang, Zhaoji Chen, Xin Yu, ... Xuexin Li
10.IUPHAR综述：计算精神病学2.0——精神药理学与神经调控联合治疗精神分裂症的新工具
IUPHAR review: Computational Psychiatry 2.0. A new tool for supporting combination therapy of psychopharmacology with neuromodulation in schizophrenia
Hugo Geerts
11.靶向卵巢癌铁死亡的自然化合物：研究进展与应用潜力
Natural compounds targeting ferroptosis in ovarian cancer: Research progress and application potential
Yuanyuan Zhao, Lichao Lu, Xingying Chen, Qiaozhi Yin
12.药用植物天然产物通过菌群-肠-轴介导的健康效益
Health benefits of medicinal plant natural products via microbiota-mediated different gut axes
Xiang Li, Yufan Liu, Ning Liu, Hanning Wu, ... Jie Zhang
13.信号素3A在阿尔茨海默病及其他衰老相关疾病发病机制中的作用
The role of semaphorin 3A in the pathogenesis and progression of Alzheimer’s disease and other aging-related diseases: A comprehensive review
Jiayu Yuan, Rui Huang, Jianfei Nao, Xiaoyu Dong
14.中医药与天然产物在肝细胞癌治疗中的生物学机制与治疗潜力
Traditional Chinese medicine and natural products in management of hepatocellular carcinoma: Biological mechanisms and therapeutic potential
Yunqing Xun, Guang Chen, Guoyi Tang, Cheng Zhang, ... Yibin Feng
15.人工智能在中枢-外周器官互作中的运用：药物研发与临床试验的未来
Artificial intelligence in central-peripheral interaction organ crosstalk: the future of drug discovery and clinical trials
Yufeng Chen, Mingrui Yang, Qian Hua
16.肥胖与线粒体解偶联——基于一氧化碳的代谢疾病药理学机遇
Obesity and mitochondrial uncoupling – an opportunity for the carbon monoxide-based pharmacology of metabolic diseases
Aleksandra Danielak, Marcin Magierowski
Regular Articles（原创研究）
17.低LDL-C水平增加阿司匹林治疗患者的出血风险：一项15年真实世界大样本研究
Low LDL-cholesterol drives the risk of bleeding in patients treated with aspirin: A 15-year study in a real-world large population
Valentina Trimarco, Raffaele Izzo, Daniela Pacella, Fahimeh Varzideh, ... Gaetano Santulli
18.青藤碱衍生物通过NRF2/HO-1/NQO1通路抑制线粒体功能障碍和氧化应激缓解胶原诱导性关节炎小鼠骨破坏
A sinomenine derivative alleviates bone destruction in collagen-induced arthritis mice by suppressing mitochondrial dysfunction and oxidative stress via the NRF2/HO-1/NQO1 signaling pathway
Wan-Yi Guo, Qi-Min Wu, Hao-Feng Zeng, Yu-Lian Chen, ... Hu-Dan Pan
19.TPI1通过招募AKT增强MDM2磷酸化促进膀胱癌中p53泛素化
TPI1 promotes p53 ubiquitination in bladder cancer by recruiting AKT to enhance MDM2 phosphorylation
Chenyang Wang, Shun Wan, Kunpeng Li, Siyu Chen, ... Li Yang
20.IUPHAR论文：裸盖菇素通过5-HT2A受体在慢性疼痛小鼠模型中产生长效效应
IUPHAR Article: Psilocybin induces long-lasting effects via 5-HT2A receptors in mouse models of chronic pain
Eda Koseli, Belle Buzzi, Torin Honaker, Yogesh Rakholia, ... M. Imad Damaj
21.双重靶向线粒体Lon蛋白酶1与糜蛋白酶样蛋白酶体活性：恶性星形细胞瘤模型的潜在治疗策略
Dual targeting of the mitochondrial Lon peptidase 1 and the chymotrypsin-like proteasome activity as a potential therapeutic strategy in malignant astrocytoma models
Christopher Douglas, Shashi Jain, Naomi Lomeli, Javier Lepe, ... Daniela A. Bota
22.CHPF2作为新型生物标志物及冬凌草甲素作为肝细胞癌潜在治疗剂
CHPF2 as a novel biomarker and ponicidin as a potential therapeutic agent in hepatocellular carcinoma
Zuhui Liang, Yingyi Ye, Zhihong Deng, Huan Lan, ... Caiyan Wang
23.癫痫发生过程中TrkB-FL受体的切割：来自海人酸模型和人类样本的启示
Cleavage of the TrkB-FL receptor during epileptogenesis: insights from a kainic acid-induced model of epilepsy and human samples
Leonor Ribeiro-Rodrigues, João Fonseca-Gomes, Sara L. Paulo, Ricardo Viais, ... Maria José Diógenes
24.双重抑制肝脏ACLY和ACSS2：通过减少脂肪生成和增强线粒体功能对抗NAFLD的协同策略
Dual inhibition of hepatic ACLY and ACSS2: A synergistic approach to combat NAFLD through lipogenesis reduction and mitochondrial enhancement
Mengdi Zhang, Jinliang Ji, Yuanyuan Lei, Fujian Qin, ... Zhixia Qiu
25.CCR1抑制增强多发性骨髓瘤细胞对糖皮质激素治疗的敏感性
CCR1 inhibition sensitizes multiple myeloma cells to glucocorticoid therapy
Bert Luyckx, Maaike Van Trimpont, Fien Declerck, Eleni Staessens, ... Karolien De Bosscher
26.人参皂苷Rb1与小檗碱通过GDF15/HAMP通路协同防治2型糖尿病：空间转录组学新见解
Ginsenoside Rb1 and berberine synergistically protect against type 2 diabetes mellitus via GDF15/HAMP pathway throughout the liver lobules: Insights from spatial transcriptomics analysis
Rongfang Guo, Shuying Zhang, Anyao Li, Ping Zhang, ... Xiaohui Fan
27.子宫肌层来源MSCs因缺乏IFN-γ反应显著改善抗TNFα难治性IBD患者的多个参数
Lack of IFN-γ response of human uterine myometrium-derived MSCs significantly improve multiple IBD parameters compared to bone marrow MSCs: Implications for anti-TNFα-refractory patients
Li-Tzu Wang, Hsiu-Huan Wang, Shih-Sheng Jiang, Chia-Chih Chang, ... Men-Luh Yen
28.PAR2缺失损害抗肿瘤免疫并减弱抗PD1在结直肠癌中的疗效
PAR2 deficiency impairs antitumor immunity and attenuates anti-PD1 efficacy in colorectal cancer
Zilin Liu, Xuehui Jiang, Ziliang Ke, Weihong Wang, ... Yun Dai
29.DIORS：通过结构与特征整合驱动方法增强药物-靶点相互作用预测并发现潜在靶向分子
DIORS: Enhancing drug-target interaction prediction via structure and signature integrated-driven approach and discovering potential targeted molecules
Yiran Tang, Shengqiao Gao, Dan Luo, Xuyong Jiang, ... Wenxia Zhou
30.靶向USP47通过调控c-Myc去泛素化增强KRASG12C突变非小细胞肺癌对KRAS抑制剂的敏感性
Targeting USP47 enhances the efficacy of KRAS inhibitor in KRASG12C mutated non-small cell lung cancer by controlling deubiquitination of c-Myc
Hyungkyung Shin, SuA Hwang, Jeong Hyun Jeong, Sang Chul Shin, ... Eun Joo Song
31.打破铁过载与miR-122协同作用以挽救MASLD中的脂质积累与过氧化
Breaking the synergism of iron overload and miR-122 to rescue lipid accumulation and peroxidation in MASLD
Yuxiao Tang, Zelong Gao, Jianxin Yang, Chenqi Li, ... Dongyao Wang
32.NAALAD2突变破坏早期视网膜发育中感光细胞与视网膜色素上皮细胞的命运
NAALAD2 mutations disrupt the fate of photoreceptor cells and retinal pigment epithelial cells during early retinal development
Yuanjie Qian, Jian Gao, Zheming Zhang, Yixuan Chen, ... Shan Duan
33.参芎益心汤多糖通过肠道外泌体miR-21调控发挥抗心肌缺血再灌注损伤作用
Shenxiong Yixin Decoction polysaccharides exert therapeutic effects against myocardial ischemia-reperfusion injury via intestinal exosomal microRNA-21 regulation
De-Sheng Xu, Yan Wang, Zi-Rui Li, Ping-Li Mo, ... Hua Zhou
34.心脏PDK4促进中性粒细胞PFKL甲基化并驱动糖尿病心肌梗死的先天免疫反应
Cardiac PDK4 promotes neutrophilic PFKL methylation and drives the innate immune response in diabetic myocardial infarction
Song Yang, Longxin Yan, Lang Chen, Gaijuan Su, ... Lihong Liu
35.高强度他汀促进PCSK9分泌与主动脉瓣钙化：体外与临床证据
High-Intensity Statins Promote PCSK9 Secretion and aortic valve calcification in patients with severe aortic stenosis: In vitro and clinical evidence
Veronika A. Myasoedova, Matteo Franchi, Donato De Giorgi, Alice Bonomi, ... Paolo Poggio
36.外源性天冬酰胺对结直肠肿瘤生长、17β-雌二醇水平及芳香化酶的性别特异性影响
Sex-specific effects of exogenous asparagine on colorectal tumor growth, 17β-estradiol levels, and aromatase
Oladimeji Aladelokun, Katherine Benitez, Yuying Wang, Abhishek Jain, ... Caroline H. Johnson
37.PTPRG-AS1通过ceRNA轴调控KITLG/KIT通路促进胃癌恶性进展及苦参注射液干预作用
PTPRG-AS1 regulates the KITLG/KIT pathway through the ceRNA axis to promote the malignant progression of gastric cancer and the intervention effect of Compound Kushen injection on it
Chao Wu, Yifei Gao, Zhengsen Jin, Zhihong Huang, ... Jiarui Wu
38.靶向应激诱导升高的血浆二肽基肽酶4活性可逆转肿瘤免疫抑制
Elevated activity of plasma dipeptidyl peptidase 4 upon stress can be targeted to reverse tumor immunosuppression
Peipei Li, Menghe Liang, Junlin Zhu, Jian Chen, ... Yuting Ma

八、抗病毒研究 (2025年第237卷)

May 2025 - Volume 237（2025年5月第237卷）
https://www.sciencedirect.com/journal/antiviral-research/vol/237/suppl/C

Short communication（简报）
1.口服4'-氟尿苷挽救小鼠免于晚期淋巴细胞性脉络丛脑膜炎病毒感染
Oral 4′-fluorouridine rescues mice from advanced lymphocytic choriomeningitis virus infection
Jonna B. Westover, Kie Hoon Jung, Shuli Mao, Alexander A. Kolykhalov, ... Brian B. Gowen
Research article（研究文章）
2.高通量筛选与计算机数据分析在医疗紧急情况下的效率：有效抗病毒3CL蛋白酶抑制剂的鉴定
The efficiency of high-throughput screening (HTS) and in-silico data analysis during medical emergencies: Identification of effective antiviral 3CLpro inhibitors
Debora Zian, Daniela Iaconis, Simone Nenci, Alessandra Crusco, ... MariaPia Catalani
3.植物药筛选揭示小檗碱抗人腺病毒活性
Screening of botanical drugs reveals the potential anti-human adenovirus activity of berberine
Junyuan Cao, Hao Zhang, Jixiang Zhang, Jinlin Wang, ... Leike Zhang
4.冠状病毒药物重定位评估：宿主靶向亚氨基糖的广谱抗病毒活性及直接作用抗病毒剂的验证
Assessment of repurposed compounds against coronaviruses highlights the antiviral broad-spectrum activity of host-targeting iminosugars and confirms the activity of potent directly acting antivirals
Juliane Brun, Benediktus Yohan Arman, Michelle L. Hill, J.L. Kiappes, ... Nicole Zitzmann
5.恩替卡韦降低HBV DNA整合的机制
Mechanism of entecavir-induced reduction of HBV DNA integration
Danny Ka-Ho Wong, Ning Chow, Hoi Tang Ma, Ka Yan Wong, ... Man-Fung Yuen
6.猴痘病毒胸苷激酶催化磷酸化反应的结构与机制解析
Structural and mechanistic insight into the phosphorylation reaction catalyzed by mpox virus thymidine kinase
Tenan Zhang, Xiang Chen, Chengcheng Tao, Haojun Huang, ... Wei Wang
7.阿帕替尼通过TFEB驱动的溶酶体生物发生降解病毒蛋白抑制汉坦病毒
Apatinib inhibits HTNV by stimulating TFEB-driven lysosome biogenesis to degrade viral protein
Qikang Ying, Xiaoxiao Zhang, Tianle Gu, Junmei Zhang, ... Fang Wang
8.GS-1阻断疱疹病毒进入并广谱抑制包膜病毒
GS-1 blocks entry of herpes viruses and more broadly inhibits enveloped viruses
E.A. Monson, M.G. Lloyd, R.I. Johnson, K. Caracciolo, ... K.J. Helbig
9.广谱抗病毒铁锈醇类似物通过影响病毒蛋白翻译和肌动蛋白重塑抑制登革热病毒感染
Broad-spectrum antiviral ferruginol analog affects the viral proteins translation and actin remodeling during dengue virus infection
Vicky C. Roa-Linares, Liliana A. Betancur-Galvis, Miguel A. González-Cardenete, Mariano A. Garcia-Blanco, Juan C. Gallego-Gomez
10.纳米颗粒分散姜黄素抑制肠道病毒复制
Curcumin dispersed with colloidal nano-particles inhibits enteric viruses replication
Maciej Przybylski, Magdalena Guzowska, Olga Gazi, Jakub Urbański, Pawel Bieganowski
Short communication（短讯）
11.贝尼福布韦与鲁扎斯韦联用体外显示强效协同抗病毒活性且体内安全性良好
Bemnifosbuvir and ruzasvir in combination exhibit potent synergistic antiviral activity in vitro while maintaining a favorable nonclinical safety profile in vivo
Steven S. Good, Shouqi Luo, Kai Lin, Alex Vo, ... Jean-Pierre Sommadossi
Research article（研究文章）
12.CVA16感染通过激活hSCARB2敲入小鼠TLR2/MYD88/TNF-α/CXCL1信号通路导致神经损伤
CVA16 infection causes neurological injury by engaging TLR2/MYD88/TNF-α/CXCL1 signalling pathway in hSCARB2 knock-in mice
Yu Wang, Yong Wu, Yuya Wang, Rui Xiong, ... Changfa Fan
13.山奈酚衍生物作为新型广谱抗病毒剂增强I型干扰素信号
Kaempferide enhances type I interferon signaling as a novel broad-spectrum antiviral agent
Ruikun Du, Jiawen Sun, Chunlei Zhang, Chenglong Chen, ... Yun-Jia Ning
14.无HBV感染的cccDNA稳定细胞系用于抗病毒药物筛选
A hepatitis B virus-free cccDNA-producing stable cell for antiviral screening
Chengqian Feng, Jingrong Shi, Yunfu Chen, Sisi Chen, ... Feng Li
15.S2结构域融合肽作为β冠状病毒模拟物及新型病毒-宿主膜融合抑制剂
The fusion peptide of the spike protein S2 domain may be a mimetic analog of β-coronaviruses and serve as a novel virus-host membrane fusion inhibitor
Abass Alao Safiriyu, Afaq Hussain, Nikesh Dewangan, Grishma Kasle, ... Jayasri Das Sarma
16.宿主RNA结合蛋白与特殊病毒RNA翻译机制：潜在抗病毒靶点
Host RNA-binding proteins and specialized viral RNA translation mechanisms: Potential antiviral targets
Leandro Fernández-García, Mariano A. Garcia-Blanco
17.肝选择性二氢喹啉酮类化合物在体外和体内抗甲型肝炎病毒活性
Hepato-selective dihydroquinolizinones active against hepatitis A virus in vitro and in vivo
Ichiro Misumi, Zhizhou Yue, Zhengyuan Jiang, Anilkumar Karampoori, ... You Li
Review article（综述文章）
18.呼吸道合胞病毒L聚合酶功能与结构研究进展
Insights in the RSV L polymerase function and structure
Brecht Bonneux, Martina Ceconi, Kim Stobbelaar, Florence Herschke, Peter Delputte
Research article（研究文章）
19.宿主靶向药物地尔硫卓增强直接作用抗病毒剂对甲型流感和SARS-CoV-2的活性
Host-targeted repurposed diltiazem enhances the antiviral activity of direct acting antivirals against Influenza A virus and SARS-CoV-2
Blandine Padey, Clément Droillard, Victoria Dulière, Julien Fouret, ... Andrés Pizzorno
20.靶向宿主转录因子HSF1在体外和体内抑制人巨细胞病毒复制
Targeting the host transcription factor HSF1 prevents human cytomegalovirus replication in vitro and in vivo
Dilruba Akter, Juthi Biswas, Shima Moradpour, Meghan F. Carter, ... Gary C. Chan
21.替诺福韦艾拉酚胺与富马酸替诺福韦二吡呋酯相比促进内脏脂肪组织增重并损害脂肪酸代谢相关信号通路
Tenofovir alafenamide promotes weight gain and impairs fatty acid metabolism-related signaling pathways in visceral fat tissue compared to tenofovir disoproxil fumarate
Bryan Dulion, Arnold Z. Olali, Niyati Patel, Amber K. Virdi, ... Ryan D. Ross
22.临床阶段泛冠状病毒融合抑制剂IPB29的临床前全面表征
Comprehensive preclinical characterization of IPB29, a pan-coronavirus fusion inhibitor under clinical trials
Yuanmei Zhu, Zhongcai Gao, Xiaoli Feng, Yue Hu, ... Yuxian He
Review article（综述文章）
23.单纯疱疹病毒感染管理现状：当前疗法与未来方向
Overview on the management of herpes simplex virus infections: Current therapies and future directions
Alexander Birkmann, Rob Saunders
24.劫持JAK抑制剂：作为潜在抗病毒分子的JAK抑制剂小综述
Hijacking JAKis: JAK inhibitors as potential antiviral molecules, a mini review
Claudie Eber, Eloi R. Verrier

九、英国药理学杂志 (2025年第182卷第9-10期)

（一）May 2025 - Volume 182 - Issue 9（2025年5月第182卷第9期）
https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2025/182/9

RESEARCH ARTICLE（研究文章）
1.α-肾上腺素受体阻滞剂酚妥拉明通过局麻药结合位点抑制电压门控钠通道
α-Adrenoreceptor blocker phentolamine inhibits voltage-gated sodium channels via the local anaesthetic binding site
Idil Toklucu, Vishal Sudha Bhagavath Eswaran, Raya Atlanta Bott, Aylin Bilge Kesdoğan, Arnim Johannes Gaebler, Julia Stingl, Ralf Hausmann, Jannis Körner, Angelika Lampert
2.硫胺素缺乏通过促进巨噬细胞糖酵解重编程加重小鼠实验性结肠炎
Thiamine deficiency aggravates experimental colitis in mice by promoting glycolytic reprogramming in macrophages
Xiaohua Pan, Zhengnan Ren, Wenjie Liang, Xiaoliang Dong, Jiahong Li, Lili Wang, Madhav Bhatia, Li-Long Pan, Jia Sun
3.MC16促进线粒体生物合成并改善急性及糖尿病肾病
MC16 promotes mitochondrial biogenesis and ameliorates acute and diabetic nephropathy
Austin D. Thompson, Kevin A. Hurtado, Jaroslav Janda, Natalie E. Scholpa, Baerbel Rohrer, Rick G. Schnellmann
4.阿尔茨海默病药物治疗新进展：糖皮质激素调节剂达唑可利坦(CORT113176)在临床前小鼠模型中的疗效
Advancing Alzheimer's disease pharmacotherapy: efficacy of glucocorticoid modulation with dazucorilant (CORT113176) in preclinical mouse models
Geoffrey Canet, Charleine Zussy, Mathieu Vitalis, Françoise Morin, Nathalie Chevallier, Hazel Hunt, Sylvie Claeysen, Marine Blaquière, Nicola Marchi, Emmanuel Planel, Onno C. Meijer, Catherine Desrumaux, Laurent Givalois
5.人参皂苷Rb1通过Piezo1抑制剪切力诱导的血小板活化及动脉血栓形成
Involvement of Piezo 1 in inhibition of shear-induced platelet activation and arterial thrombosis by ginsenoside Rb1
Yilin Wang, Lu Liu, Jia Li, Yue You, Shunli Xiao, Jiantao Feng, Xiaojie Yin, Fulong Liao, Yun You
6.白色脂肪组织离体神经源性脂解反应的特征研究
Characterisation of neurogenic lipolytic responses in white adipose tissue ex vivo
Kayleigh E. Goddard, Samuel J. Fountain
7.脂肪酸结合蛋白3激活循环单核细胞的内皮黏附并损害内皮血管生成
Fatty acid binding protein 3 activates endothelial adhesion of circulating monocytes and impairs endothelial angiogenesis
Yen-Wen Wu, Jaw-Wen Chen, Hao-Yuan Tsai, Hsin-Bang Leu, Chia-Chi Chang, Ting-Ting Chang
8.Spinster同源蛋白2(Spns2)依赖性鞘氨醇-1-磷酸转运作为治疗靶点的评估
Assessment of Spinster homologue 2 (Spns2)-dependent transport of sphingosine-1-phosphate as a therapeutic target
Yugesh Kharel, Tao Huang, Kyle Dunnavant, Daniel Foster, George M. P. R. Souza, Katherine E. Nimchuk, Andrea R. Merchak, Caitlin M. Pavelec, Zuzanna J. Juskiewicz, Simon S. Alexander, Alban Gaultier, Stephen B. G. Abbott, Jung-Bum Shin, Brant E.
Isakson, Wehao Xu, Norbert Leitinger, Webster L. Santos, Kevin R. Lynch
9.平滑肌细胞Piezo1是表型转换和新内膜增生所必需的
Smooth muscle cell Piezo1 is essential for phenotypic switch and neointimal hyperplasia
Fei-Ran Zhang, Jie Tang, Ying Lai, Shi-Qi Mo, Zhuo-Miao Lin, Qing-Qing Lei, Cong-Cong Han, An-Dong Zhou, Xiao-Fei Lv, Cheng Wang, Jing-Song Ou, Jia-Guo Zhou, Rui-Ping Pang
10.沉默人原代肌细胞药物转运蛋白调节阿托伐他汀药代动力学的初步研究
Silencing drug transporters in human primary muscle cells modulates atorvastatin pharmacokinetics: A pilot study
Emilia Hoste, Louise Deldicque, Giulio G. Muccioli, Nadtha Panin, Romano Terrasi, Adrien Paquot, Maxime Lingurski, Sébastien Pyr dit Ruys, Vincent Haufroid, Laure Elens

（二）May 2025 - Volume 182 - Issue 10 （2025年5月第182卷第10期）

https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2025/182/10

NATURAL PRODUCTS AND CANCER: FROM DRUG DISCOVERY TO PREVENTION AND THERAPY - THEMED ISSUE REVIEW（自然产物与癌症：从药物发现到预防和治疗 - 主题综述）
1.单宁在癌症预防和治疗中的应用
Tannins in cancer prevention and therapy
Robert Kleszcz,  Aleksandra Majchrzak-Celińska,  Wanda Baer-Dubowska
2.靶向肿瘤血管生成的天然产物
Natural products targeting tumour angiogenesis
Xiaohua Lu,  Lara Johanna Friedrich,  Thomas Efferth
3.通过影响组蛋白甲基化/去甲基化调控表观遗传机制的天然产物：靶向癌细胞
Natural products modulating epigenetic mechanisms by affecting histone methylation/demethylation: Targeting cancer cells
Dawid Dorna,  Adriana Grabowska,  Jarosław Paluszczak
4.从平凡到经典：青藤碱作为多功能治疗剂
From mundane to classic: Sinomenine as a multi-therapeutic agent
Dan Li,  Zhangfeng Zhong,  Chung-Nga Ko,  Tiantian Tian,  Chao Yang
5.预防和治疗胰腺癌的植物化学物质：当前进展与未来展望
Phytochemicals for the prevention and treatment of pancreatic cancer: Current progress and future prospects
Nicolette Casarcia,  Patrick Rogers,  Emma Guld,  Samvit Iyer,  Yutong Li,  Jack T. Burcher,  Lindsay K. DeLiberto,  Sabyasachi Banerjee,  Anupam Bishayee
6.靶向乳腺癌血管生成的天然黄酮类化合物潜力（综述）
Potential of natural flavonoids to target breast cancer angiogenesis (review)
Yuetong Wang,  Mengge Huang,  Xintong Zhou,  Huayao Li,  Xiaoran Ma,  Changgang Sun
7.大豆异黄酮作为靶向多信号通路的化学预防剂用于癌症预防和治疗
Soy-derived isoflavones as chemo-preventive agents targeting multiple signalling pathways for cancer prevention and therapy
Agnieszka Kaufman-Szymczyk,  Justyna Jalmuzna,  Katarzyna Lubecka-Gajewska
NATURAL PRODUCTS AND CANCER: FROM DRUG DISCOVERY TO PREVENTION AND THERAPY - THEMED ISSUE ARTICLE（自然产物与癌症：从药物发现到预防和治疗 - 主题论文）
8.发现一种靶向非小细胞肺癌细胞中HSC70-LAMP2A相互作用的分子伴侣介导自噬强效抑制剂
Discovery of a potent inhibitor of chaperone-mediated autophagy that targets the HSC70–LAMP2A interaction in non-small cell lung cancer cells
Rui-Fang Dong,  Cheng-Jiao Qin,  Yong Yin,  Liang-Liang Han,  Cheng-Mei Xiao,  Kai-Di Wang,  Rong-Yuan Wei,  Yuan-Zheng Xia,  Ling-Yi Kong
9.7I（结构修饰的青藤碱衍生物）通过抑制胶质母细胞瘤增殖和诱导坏死性凋亡（进一步介导溶酶体细胞死亡）发挥双重抗GBM作用
7 I, a structurally modified sinomenine, exerts dual anti-GBM effects by inhibiting glioblastoma proliferation and inducing necroptosis which further mediates lysosomal cell death
Hong Yang,  Bin Jiang,  Wan Li,  Guanhua Du,  Fang Xu,  Yizhi Zhang,  Yihui Yang,  Sen Zhang,  Wanxin Cao,  Xiaoxue Li,  Xu Zhang,  Tengfei Ji,  Jinhua Wang

十、临床药代动力学 (2025年第64卷第5期)

May 2025 -Volume 64 - Issue 5（2025年5月第64卷第5期）
https://link.springer.com/journal/40262/volumes-and-issues/64-5

Review Article（综述文章）
1.囊性纤维化儿科患者的抗感染药物：群体药代动力学分析全面综述
Anti-infectives in Pediatric Patients with Cystic Fibrosis: A Comprehensive Review of Population Pharmacokinetic Analyses
Aysenur Yaliniz, Mehdi El Hassani … Amélie Marsot
Systematic Review（系统综述）
2.成人群体中多粘菌素E（粘菌素）与多粘菌素B药代动力学研究的系统综述
A Systematic Review of Pharmacokinetic Studies of Colistin and Polymyxin B in Adult Populations
Puteri Juanita Zamri, Sazlyna Mohd Sazlly Lim … Mohd Hafiz Abdul-Aziz
Original Research Article（原创研究文章）
3.低温控制对心脏骤停复苏患者青霉素/β-内酰胺酶抑制剂组合血浆与软组织药代动力学的影响
Impact of Hypothermic Temperature Control on Plasma and Soft Tissue Pharmacokinetics of Penicillin/Beta-Lactamase Inhibitor Combinations in Patients Resuscitated After Cardiac Arrest
Alexandra-Maria Stommel, Peter Matzneller … Markus Zeitlinger
4.普格列汀（DBPR108）在2型糖尿病患者中的药代动力学与药效学研究：一种每日一次的DPP-4抑制剂
Pharmacokinetics and Pharmacodynamics of Prusogliptin (DBPR108), a Once-Daily Dipeptidyl Peptidase-4 Inhibitor, in Patients with Type 2 Diabetes
Wenfang Liu, Kexu Yang … Shan Jing
5.基于模型的帕唑帕尼在真实世界癌症患者中的剂量优化
Model-Informed Dose Optimization of Pazopanib in Real-World Patients with Cancer
Zhiyuan Tan, Swantje Völler … Dirk Jan A. R. Moes
6.Tarlatamab（半衰期延长的DLL3靶向双特异性T细胞衔接器）在经治小细胞肺癌患者中的群体药代动力学
Population Pharmacokinetics of Tarlatamab, a Half-Life Extended DLL3-Directed Bispecific T-Cell Engager in Patients with Previously Treated Small Cell Lung Cancer
Stephanie Kong, Mukul Minocha … Chih-Wei Li
7.COVID-19住院患者中瑞德西韦及其代谢物GS-441524的群体药代动力学模型
Population Pharmacokinetic Modelling of Remdesivir and Its Metabolite GS-441524 in Hospitalised Patients with COVID-19
Darren M. Roberts, Xin Liu … Jason A. Roberts
8.慢性疼痛患者中Fepixnebart（LY3016859）与表皮调节素的群体药代动力学与药效学研究
Population Pharmacokinetics and Pharmacodynamics of Fepixnebart (LY3016859) and Epiregulin in Patients with Chronic Pain
Douglas E. James, Jason Bailey … Rik Schoemaker
9.脓毒症儿童美罗培南分布与清除的变异性：基于群体的药代动力学及肾脏生物标志物评估
Variability in Meropenem Distribution and Clearance in Children with Sepsis: Population-Based Pharmacokinetics with Assessment of Renal Biomarkers
Jennifer Le, Julie Huynh … John S. Bradley
10.药物代谢组学检测（潜在）活体肾捐献者与肾移植受者尿液中多种未报道的美托洛尔代谢物 
Pharmacometabolomics Detects Various Unreported Metoprolol Metabolites in Urine of (Potential) Living Kidney Donors and Kidney Transplant Recipients
Wietske A. Heddema, Marieke A. J. Hof … the TransplantLines Investigators